Parallel artificial liquid membrane extraction of psychoactive analytes: a novel approach in therapeutic drug monitoring

Katharina Norgren  Olsen; Kristine Skoglund  Ask; Stig Pedersen-Bjergaard; Astrid Gjelstad

doi:10.4155/bio-2017-0250

Parallel artificial liquid membrane extraction of psychoactive analytes: a novel approach in therapeutic drug monitoring

Katharina Norgren Olsen, Kristine Skoglund Ask, Stig Pedersen-Bjergaard, Astrid Gjelstad

5 Citations (Scopus)

Abstract

Aim: Liquid-liquid extraction is widely used in therapeutic drug monitoring of antipsychotics, but difficulties in automation of the technique can result in long operational time. In this paper, parallel artificial liquid membrane extraction was used for extraction of serotonin- and serotonin-norepinephrine reuptake inhibitors from human plasma, and an approach to automate the technique was investigated. Results: Eight model analytes were extracted from 125 μl human plasma with recoveries in the range 72-111% (relative standard deviation [RSD] ≤12.8%). A semiautomated pipettor was successfully utilized in the procedure, reducing the manual handling time. Real patient samples were analyzed with satisfying accuracy. Conclusion: A semiautomated extraction of serotonin-and serotonin-norepinephrine reuptake inhibitors by parallel artificial liquid membrane extraction extraction was successfully performed.

Original language	English
Journal	Bioanalysis
Volume	10
Pages (from-to)	385-395
ISSN	1757-6180
DOIs	https://doi.org/10.4155/bio-2017-0250
Publication status	Published - Mar 2018

Access to Document

10.4155/bio-2017-0250

Cite this

@article{0f4290206bec4c6aa29f2f8b5d8b3ec0,

title = "Parallel artificial liquid membrane extraction of psychoactive analytes: a novel approach in therapeutic drug monitoring",

abstract = "Aim: Liquid-liquid extraction is widely used in therapeutic drug monitoring of antipsychotics, but difficulties in automation of the technique can result in long operational time. In this paper, parallel artificial liquid membrane extraction was used for extraction of serotonin- and serotonin-norepinephrine reuptake inhibitors from human plasma, and an approach to automate the technique was investigated. Results: Eight model analytes were extracted from 125 μl human plasma with recoveries in the range 72-111% (relative standard deviation [RSD] ≤12.8%). A semiautomated pipettor was successfully utilized in the procedure, reducing the manual handling time. Real patient samples were analyzed with satisfying accuracy. Conclusion: A semiautomated extraction of serotonin-and serotonin-norepinephrine reuptake inhibitors by parallel artificial liquid membrane extraction extraction was successfully performed.",

author = "Olsen, {Katharina Norgren} and Ask, {Kristine Skoglund} and Stig Pedersen-Bjergaard and Astrid Gjelstad",

year = "2018",

month = mar,

doi = "10.4155/bio-2017-0250",

language = "English",

volume = "10",

pages = "385--395",

journal = "Bioanalysis",

issn = "1757-6180",

publisher = "Future Science",

}

TY - JOUR

T1 - Parallel artificial liquid membrane extraction of psychoactive analytes: a novel approach in therapeutic drug monitoring

AU - Olsen, Katharina Norgren

AU - Ask, Kristine Skoglund

AU - Pedersen-Bjergaard, Stig

AU - Gjelstad, Astrid

PY - 2018/3

Y1 - 2018/3

N2 - Aim: Liquid-liquid extraction is widely used in therapeutic drug monitoring of antipsychotics, but difficulties in automation of the technique can result in long operational time. In this paper, parallel artificial liquid membrane extraction was used for extraction of serotonin- and serotonin-norepinephrine reuptake inhibitors from human plasma, and an approach to automate the technique was investigated. Results: Eight model analytes were extracted from 125 μl human plasma with recoveries in the range 72-111% (relative standard deviation [RSD] ≤12.8%). A semiautomated pipettor was successfully utilized in the procedure, reducing the manual handling time. Real patient samples were analyzed with satisfying accuracy. Conclusion: A semiautomated extraction of serotonin-and serotonin-norepinephrine reuptake inhibitors by parallel artificial liquid membrane extraction extraction was successfully performed.

AB - Aim: Liquid-liquid extraction is widely used in therapeutic drug monitoring of antipsychotics, but difficulties in automation of the technique can result in long operational time. In this paper, parallel artificial liquid membrane extraction was used for extraction of serotonin- and serotonin-norepinephrine reuptake inhibitors from human plasma, and an approach to automate the technique was investigated. Results: Eight model analytes were extracted from 125 μl human plasma with recoveries in the range 72-111% (relative standard deviation [RSD] ≤12.8%). A semiautomated pipettor was successfully utilized in the procedure, reducing the manual handling time. Real patient samples were analyzed with satisfying accuracy. Conclusion: A semiautomated extraction of serotonin-and serotonin-norepinephrine reuptake inhibitors by parallel artificial liquid membrane extraction extraction was successfully performed.

U2 - 10.4155/bio-2017-0250

DO - 10.4155/bio-2017-0250

M3 - Journal article

C2 - 29451001

SN - 1757-6180

VL - 10

SP - 385

EP - 395

JO - Bioanalysis

JF - Bioanalysis

ER -

Parallel artificial liquid membrane extraction of psychoactive analytes: a novel approach in therapeutic drug monitoring

Abstract

Access to Document

Fingerprint

Cite this