Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments

D. Ehmann; J. Wendler; L. Koeninger; I. S. Larsen; T. Klag; J. Berger; A. Marette; M. Schaller; E. F. Stange; N. P. Malek; B. A. H. Jensen; J. Wehkamp

doi:10.1073/pnas.1817376116

Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments

D. Ehmann, J. Wendler, L. Koeninger, I. S. Larsen, T. Klag, J. Berger, A. Marette, M. Schaller, E. F. Stange, N. P. Malek, B. A. H. Jensen, J. Wehkamp

24 Citations (Scopus)

Original language	English
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	116
Issue number	9
Pages (from-to)	3746-3751
ISSN	0027-8424
DOIs	https://doi.org/10.1073/pnas.1817376116
Publication status	Published - 26 Feb 2019

Keywords

antimicrobial peptides
alpha-defensins
intestinal barrier
proteolytic digestion
host-microbiota interaction

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10.1073/pnas.1817376116

3746.full.pdfFinal published version, 1.19 MBLicence: CC BY-NC-ND

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Ehmann, D., Wendler, J., Koeninger, L., Larsen, I. S., Klag, T., Berger, J., Marette, A., Schaller, M., Stange, E. F., Malek, N. P., Jensen, B. A. H., & Wehkamp, J. (2019). Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments. Proceedings of the National Academy of Sciences of the United States of America, 116(9), 3746-3751. https://doi.org/10.1073/pnas.1817376116

Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments. / Ehmann, D.; Wendler, J.; Koeninger, L. et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 9, 26.02.2019, p. 3746-3751.

Research output: Contribution to journal › Journal article › Research › peer-review

Ehmann, D, Wendler, J, Koeninger, L, Larsen, IS, Klag, T, Berger, J, Marette, A, Schaller, M, Stange, EF, Malek, NP, Jensen, BAH & Wehkamp, J 2019, 'Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 9, pp. 3746-3751. https://doi.org/10.1073/pnas.1817376116

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AU - Larsen, I. S.

AU - Klag, T.

AU - Berger, J.

AU - Marette, A.

AU - Schaller, M.

AU - Stange, E. F.

AU - Malek, N. P.

AU - Jensen, B. A. H.

AU - Wehkamp, J.

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KW - proteolytic digestion

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M3 - Journal article

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Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments

Keywords

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