Abstract
Morphine-6-glucuronide (M-6-G) and morphine-3-glucuronide (M-3-G) are the two most important metabolites of morphine. Both are pharmacologically active, however, with different effects. M-6-G has been demonstrated capable of inducing anti-nociception and sedation, and M-3-G may induce behavioural excitation and possibly antagonise anti-nociception. Their impact on pharmacodynamics in patients in long-term treatment with oral morphine remains to be settled.
| Original language | English |
|---|---|
| Journal | Palliative Medicine |
| Volume | 16 |
| Issue number | 2 |
| Pages (from-to) | 107-14 |
| Number of pages | 8 |
| ISSN | 0269-2163 |
| Publication status | Published - Mar 2002 |
| Externally published | Yes |
Keywords
- Adult
- Aged
- Analgesics, Opioid
- Delayed-Action Preparations
- Female
- Humans
- Male
- Middle Aged
- Morphine
- Morphine Derivatives
- Neoplasms
- Pain
