PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

Ana Mendanha Falcão; Mandy Meijer; Antonella Scaglione; Puneet Rinwa; Eneritz Agirre; Jialiang Liang; Sara C Larsen; Abeer Heskol; Rebecca Frawley; Michael Klingener; Manuel Varas-Godoy; Alexandre A S F Raposo; Patrik Ernfors; Diogo S Castro; Michael L. Nielsen; Patrizia Casaccia; Gonçalo Castelo-Branco

doi:10.1016/j.celrep.2019.03.108

PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

Ana Mendanha Falcão, Mandy Meijer, Antonella Scaglione, Puneet Rinwa, Eneritz Agirre, Jialiang Liang, Sara C Larsen, Abeer Heskol, Rebecca Frawley, Michael Klingener, Manuel Varas-Godoy, Alexandre A S F Raposo, Patrik Ernfors, Diogo S Castro, Michael L. Nielsen, Patrizia Casaccia, Gonçalo Castelo-Branco

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Abstract

Falcão et al. demonstrate that PAD2-mediated citrullination, the conversion of peptidylarginine into peptidylcitrulline, has two roles in oligodendrocyte cells. In the nucleus, PAD2 acts as a chromatin modifier contributing to efficient oligodendrocyte precursor cell differentiation, while in the cytoplasm PAD2 is required for proper oligodendrocyte myelination.

Original language	English
Journal	Cell Reports
Volume	27
Issue number	4
Pages (from-to)	1090-1102.e10
ISSN	2211-1247
DOIs	https://doi.org/10.1016/j.celrep.2019.03.108
Publication status	Published - 23 Apr 2019

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PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and MyelinationFinal published version, 4.42 MBLicence: CC BY

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Falcão, A. M., Meijer, M., Scaglione, A., Rinwa, P., Agirre, E., Liang, J., Larsen, S. C., Heskol, A., Frawley, R., Klingener, M., Varas-Godoy, M., Raposo, A. A. S. F., Ernfors, P., Castro, D. S., Nielsen, M. L., Casaccia, P., & Castelo-Branco, G. (2019). PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination. Cell Reports, 27(4), 1090-1102.e10. https://doi.org/10.1016/j.celrep.2019.03.108

Falcão, AM, Meijer, M, Scaglione, A, Rinwa, P, Agirre, E, Liang, J, Larsen, SC, Heskol, A, Frawley, R, Klingener, M, Varas-Godoy, M, Raposo, AASF, Ernfors, P, Castro, DS, Nielsen, ML, Casaccia, P & Castelo-Branco, G 2019, 'PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination', Cell Reports, vol. 27, no. 4, pp. 1090-1102.e10. https://doi.org/10.1016/j.celrep.2019.03.108

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abstract = "Falc{\~a}o et al. demonstrate that PAD2-mediated citrullination, the conversion of peptidylarginine into peptidylcitrulline, has two roles in oligodendrocyte cells. In the nucleus, PAD2 acts as a chromatin modifier contributing to efficient oligodendrocyte precursor cell differentiation, while in the cytoplasm PAD2 is required for proper oligodendrocyte myelination.",

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AU - Falcão, Ana Mendanha

AU - Meijer, Mandy

AU - Scaglione, Antonella

AU - Rinwa, Puneet

AU - Agirre, Eneritz

AU - Liang, Jialiang

AU - Larsen, Sara C

AU - Heskol, Abeer

AU - Frawley, Rebecca

AU - Klingener, Michael

AU - Varas-Godoy, Manuel

AU - Raposo, Alexandre A S F

AU - Ernfors, Patrik

AU - Castro, Diogo S

AU - Nielsen, Michael L.

AU - Casaccia, Patrizia

AU - Castelo-Branco, Gonçalo

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AB - Falcão et al. demonstrate that PAD2-mediated citrullination, the conversion of peptidylarginine into peptidylcitrulline, has two roles in oligodendrocyte cells. In the nucleus, PAD2 acts as a chromatin modifier contributing to efficient oligodendrocyte precursor cell differentiation, while in the cytoplasm PAD2 is required for proper oligodendrocyte myelination.

U2 - 10.1016/j.celrep.2019.03.108

DO - 10.1016/j.celrep.2019.03.108

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SP - 1090-1102.e10

JO - Cell Reports

JF - Cell Reports

IS - 4

ER -

PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

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