PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

Ana Mendanha Falcão; Mandy Meijer; Antonella Scaglione; Puneet Rinwa; Eneritz Agirre; Jialiang Liang; Sara C Larsen; Abeer Heskol; Rebecca Frawley; Michael Klingener; Manuel Varas-Godoy; Alexandre A S F Raposo; Patrik Ernfors; Diogo S Castro; Michael L. Nielsen; Patrizia Casaccia; Gonçalo Castelo-Branco

doi:10.1016/j.celrep.2019.03.108

PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

Ana Mendanha Falcão, Mandy Meijer, Antonella Scaglione, Puneet Rinwa, Eneritz Agirre, Jialiang Liang, Sara C Larsen, Abeer Heskol, Rebecca Frawley, Michael Klingener, Manuel Varas-Godoy, Alexandre A S F Raposo, Patrik Ernfors, Diogo S Castro, Michael L. Nielsen, Patrizia Casaccia, Gonçalo Castelo-Branco

15 Citationer (Scopus)

10 Downloads (Pure)

Abstract

Falcão et al. demonstrate that PAD2-mediated citrullination, the conversion of peptidylarginine into peptidylcitrulline, has two roles in oligodendrocyte cells. In the nucleus, PAD2 acts as a chromatin modifier contributing to efficient oligodendrocyte precursor cell differentiation, while in the cytoplasm PAD2 is required for proper oligodendrocyte myelination.

Originalsprog	Engelsk
Tidsskrift	Cell Reports
Vol/bind	27
Udgave nummer	4
Sider (fra-til)	1090-1102.e10
ISSN	2211-1247
DOI	https://doi.org/10.1016/j.celrep.2019.03.108
Status	Udgivet - 23 apr. 2019

Adgang til dokumentet

10.1016/j.celrep.2019.03.108Licens: CC BY

PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and MyelinationForlagets udgivne version, 4,42 MBLicens: CC BY

Citationsformater

Falcão, A. M., Meijer, M., Scaglione, A., Rinwa, P., Agirre, E., Liang, J., Larsen, S. C., Heskol, A., Frawley, R., Klingener, M., Varas-Godoy, M., Raposo, A. A. S. F., Ernfors, P., Castro, D. S., Nielsen, M. L., Casaccia, P., & Castelo-Branco, G. (2019). PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination. Cell Reports, 27(4), 1090-1102.e10. https://doi.org/10.1016/j.celrep.2019.03.108

Falcão, AM, Meijer, M, Scaglione, A, Rinwa, P, Agirre, E, Liang, J, Larsen, SC, Heskol, A, Frawley, R, Klingener, M, Varas-Godoy, M, Raposo, AASF, Ernfors, P, Castro, DS, Nielsen, ML, Casaccia, P & Castelo-Branco, G 2019, 'PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination', Cell Reports, bind 27, nr. 4, s. 1090-1102.e10. https://doi.org/10.1016/j.celrep.2019.03.108

@article{4ab1a8697b4f4d7a975d34a9a760ff3e,

title = "PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination",

abstract = "Falc{\~a}o et al. demonstrate that PAD2-mediated citrullination, the conversion of peptidylarginine into peptidylcitrulline, has two roles in oligodendrocyte cells. In the nucleus, PAD2 acts as a chromatin modifier contributing to efficient oligodendrocyte precursor cell differentiation, while in the cytoplasm PAD2 is required for proper oligodendrocyte myelination.",

author = "Falc{\~a}o, {Ana Mendanha} and Mandy Meijer and Antonella Scaglione and Puneet Rinwa and Eneritz Agirre and Jialiang Liang and Larsen, {Sara C} and Abeer Heskol and Rebecca Frawley and Michael Klingener and Manuel Varas-Godoy and Raposo, {Alexandre A S F} and Patrik Ernfors and Castro, {Diogo S} and Nielsen, {Michael L.} and Patrizia Casaccia and Gon{\c c}alo Castelo-Branco",

year = "2019",

month = apr,

day = "23",

doi = "10.1016/j.celrep.2019.03.108",

language = "English",

volume = "27",

pages = "1090--1102.e10",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

number = "4",

}

TY - JOUR

T1 - PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

AU - Falcão, Ana Mendanha

AU - Meijer, Mandy

AU - Scaglione, Antonella

AU - Rinwa, Puneet

AU - Agirre, Eneritz

AU - Liang, Jialiang

AU - Larsen, Sara C

AU - Heskol, Abeer

AU - Frawley, Rebecca

AU - Klingener, Michael

AU - Varas-Godoy, Manuel

AU - Raposo, Alexandre A S F

AU - Ernfors, Patrik

AU - Castro, Diogo S

AU - Nielsen, Michael L.

AU - Casaccia, Patrizia

AU - Castelo-Branco, Gonçalo

PY - 2019/4/23

Y1 - 2019/4/23

N2 - Falcão et al. demonstrate that PAD2-mediated citrullination, the conversion of peptidylarginine into peptidylcitrulline, has two roles in oligodendrocyte cells. In the nucleus, PAD2 acts as a chromatin modifier contributing to efficient oligodendrocyte precursor cell differentiation, while in the cytoplasm PAD2 is required for proper oligodendrocyte myelination.

AB - Falcão et al. demonstrate that PAD2-mediated citrullination, the conversion of peptidylarginine into peptidylcitrulline, has two roles in oligodendrocyte cells. In the nucleus, PAD2 acts as a chromatin modifier contributing to efficient oligodendrocyte precursor cell differentiation, while in the cytoplasm PAD2 is required for proper oligodendrocyte myelination.

U2 - 10.1016/j.celrep.2019.03.108

DO - 10.1016/j.celrep.2019.03.108

M3 - Journal article

C2 - 31018126

SN - 2211-1247

VL - 27

SP - 1090-1102.e10

JO - Cell Reports

JF - Cell Reports

IS - 4

ER -

PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater