Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes

Tine D Clausen; Elisabeth R Mathiesen; Torben Hansen; Oluf Borbye Pedersen; Dorte M Jensen; Jeannet Lauenborg; Lone Schmidt; Peter Damm; Tine Dalsgaard Clausen; Elisabeth R Mathiesen; Torben Hansen; Oluf Pedersen; Dorte Jensen; Jeannet Lauenborg; Lone Schmidt; Peter Damm

doi:10.1210/jc.2009-0305

Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes

Tine D Clausen, Elisabeth R Mathiesen, Torben Hansen, Oluf Borbye Pedersen, Dorte M Jensen, Jeannet Lauenborg, Lone Schmidt, Peter Damm, Tine Dalsgaard Clausen, Elisabeth R Mathiesen, Torben Hansen, Oluf Pedersen, Dorte Jensen, Jeannet Lauenborg, Lone Schmidt, Peter Damm

266 Citations (Scopus)

Abstract

Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes Context: In animal studies exposure to intrauterine hyperglycemia increases the risk of cardiovascular disease through only partly understood epigenetic mechanisms. Human long-term follow-up studies on the same topic are few. Objective: To study the risk of overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus (GDM) or type 1 diabetes, and additionally to study associations between estimates of maternal hyperglycemia and outcome in the offspring Design: Follow-up study of 1,066 primarily Caucasians aged 18-27 years. Setting: Center for pregnant women with diabetes, Rigshospitalet, Denmark Participants: Offspring of women with diet-treated GDM (n=168) and an un-exposed reference group (n=141). Offspring of women with type 1 diabetes (n=160) and offspring from the background population representing an un-exposed reference group (n=128). Follow-up rate was 56% (597/1,066). Main outcome measures: Overweight: body mass index (BMI) >/= 25kg/m(2). The metabolic syndrome: the International Diabetes Federation 2006 criteria. Results: The risk of overweight was doubled in offspring of women with diet-treated GDM or type 1 diabetes compared with offspring from the background population whereas the risk of the metabolic syndrome was four and 2.5-fold increased, respectively. Offspring risk of the metabolic syndrome increased significantly with increasing maternal fasting blood glucose as well as 2-h blood glucose (during OGTT). Conclusions: Adult offspring of women with diet-treated GDM or type 1 diabetes are risk groups for overweight and the metabolic syndrome. Intrauterine hyperglycemia may in addition to genetics and other factors contribute to the pathogenesis of overweight and the metabolic syndrome.

Original language	English
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	94
Issue number	7
Pages (from-to)	2464-70
Number of pages	7
ISSN	0021-972X
DOIs	https://doi.org/10.1210/jc.2009-0305 https://doi.org/10.1210/jc.2009-0305
Publication status	Published - 1 Jul 2009

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Clausen, T. D., Mathiesen, E. R., Hansen, T., Pedersen, O. B., Jensen, D. M., Lauenborg, J., Schmidt, L., Damm, P., Clausen, T. D., Mathiesen, E. R., Hansen, T., Pedersen, O., Jensen, D., Lauenborg, J., Schmidt, L., & Damm, P. (2009). Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 94(7), 2464-70. https://doi.org/10.1210/jc.2009-0305, https://doi.org/10.1210/jc.2009-0305

Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes. / Clausen, Tine D; Mathiesen, Elisabeth R; Hansen, Torben et al.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 7, 01.07.2009, p. 2464-70.

Research output: Contribution to journal › Journal article › Research › peer-review

Clausen, TD, Mathiesen, ER, Hansen, T, Pedersen, OB, Jensen, DM, Lauenborg, J, Schmidt, L , Damm, P, Clausen, TD, Mathiesen, ER, Hansen, T, Pedersen, O, Jensen, D, Lauenborg, J, Schmidt, L & Damm, P 2009, 'Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes', Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 7, pp. 2464-70. https://doi.org/10.1210/jc.2009-0305, https://doi.org/10.1210/jc.2009-0305

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title = "Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes",

abstract = "Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes Context: In animal studies exposure to intrauterine hyperglycemia increases the risk of cardiovascular disease through only partly understood epigenetic mechanisms. Human long-term follow-up studies on the same topic are few. Objective: To study the risk of overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus (GDM) or type 1 diabetes, and additionally to study associations between estimates of maternal hyperglycemia and outcome in the offspring Design: Follow-up study of 1,066 primarily Caucasians aged 18-27 years. Setting: Center for pregnant women with diabetes, Rigshospitalet, Denmark Participants: Offspring of women with diet-treated GDM (n=168) and an un-exposed reference group (n=141). Offspring of women with type 1 diabetes (n=160) and offspring from the background population representing an un-exposed reference group (n=128). Follow-up rate was 56% (597/1,066). Main outcome measures: Overweight: body mass index (BMI) >/= 25kg/m(2). The metabolic syndrome: the International Diabetes Federation 2006 criteria. Results: The risk of overweight was doubled in offspring of women with diet-treated GDM or type 1 diabetes compared with offspring from the background population whereas the risk of the metabolic syndrome was four and 2.5-fold increased, respectively. Offspring risk of the metabolic syndrome increased significantly with increasing maternal fasting blood glucose as well as 2-h blood glucose (during OGTT). Conclusions: Adult offspring of women with diet-treated GDM or type 1 diabetes are risk groups for overweight and the metabolic syndrome. Intrauterine hyperglycemia may in addition to genetics and other factors contribute to the pathogenesis of overweight and the metabolic syndrome.",

author = "Clausen, {Tine D} and Mathiesen, {Elisabeth R} and Torben Hansen and Pedersen, {Oluf Borbye} and Jensen, {Dorte M} and Jeannet Lauenborg and Lone Schmidt and Peter Damm and Clausen, {Tine Dalsgaard} and Mathiesen, {Elisabeth R} and Torben Hansen and Oluf Pedersen and Dorte Jensen and Jeannet Lauenborg and Lone Schmidt and Peter Damm",

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T1 - Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes

AU - Clausen, Tine D

AU - Mathiesen, Elisabeth R

AU - Hansen, Torben

AU - Pedersen, Oluf Borbye

AU - Jensen, Dorte M

AU - Lauenborg, Jeannet

AU - Schmidt, Lone

AU - Damm, Peter

AU - Clausen, Tine Dalsgaard

AU - Mathiesen, Elisabeth R

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Jensen, Dorte

AU - Lauenborg, Jeannet

AU - Schmidt, Lone

AU - Damm, Peter

N1 - Export Date: 4 November 2009Source: Scopus

PY - 2009/7/1

Y1 - 2009/7/1

N2 - Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes Context: In animal studies exposure to intrauterine hyperglycemia increases the risk of cardiovascular disease through only partly understood epigenetic mechanisms. Human long-term follow-up studies on the same topic are few. Objective: To study the risk of overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus (GDM) or type 1 diabetes, and additionally to study associations between estimates of maternal hyperglycemia and outcome in the offspring Design: Follow-up study of 1,066 primarily Caucasians aged 18-27 years. Setting: Center for pregnant women with diabetes, Rigshospitalet, Denmark Participants: Offspring of women with diet-treated GDM (n=168) and an un-exposed reference group (n=141). Offspring of women with type 1 diabetes (n=160) and offspring from the background population representing an un-exposed reference group (n=128). Follow-up rate was 56% (597/1,066). Main outcome measures: Overweight: body mass index (BMI) >/= 25kg/m(2). The metabolic syndrome: the International Diabetes Federation 2006 criteria. Results: The risk of overweight was doubled in offspring of women with diet-treated GDM or type 1 diabetes compared with offspring from the background population whereas the risk of the metabolic syndrome was four and 2.5-fold increased, respectively. Offspring risk of the metabolic syndrome increased significantly with increasing maternal fasting blood glucose as well as 2-h blood glucose (during OGTT). Conclusions: Adult offspring of women with diet-treated GDM or type 1 diabetes are risk groups for overweight and the metabolic syndrome. Intrauterine hyperglycemia may in addition to genetics and other factors contribute to the pathogenesis of overweight and the metabolic syndrome.

AB - Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes Context: In animal studies exposure to intrauterine hyperglycemia increases the risk of cardiovascular disease through only partly understood epigenetic mechanisms. Human long-term follow-up studies on the same topic are few. Objective: To study the risk of overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus (GDM) or type 1 diabetes, and additionally to study associations between estimates of maternal hyperglycemia and outcome in the offspring Design: Follow-up study of 1,066 primarily Caucasians aged 18-27 years. Setting: Center for pregnant women with diabetes, Rigshospitalet, Denmark Participants: Offspring of women with diet-treated GDM (n=168) and an un-exposed reference group (n=141). Offspring of women with type 1 diabetes (n=160) and offspring from the background population representing an un-exposed reference group (n=128). Follow-up rate was 56% (597/1,066). Main outcome measures: Overweight: body mass index (BMI) >/= 25kg/m(2). The metabolic syndrome: the International Diabetes Federation 2006 criteria. Results: The risk of overweight was doubled in offspring of women with diet-treated GDM or type 1 diabetes compared with offspring from the background population whereas the risk of the metabolic syndrome was four and 2.5-fold increased, respectively. Offspring risk of the metabolic syndrome increased significantly with increasing maternal fasting blood glucose as well as 2-h blood glucose (during OGTT). Conclusions: Adult offspring of women with diet-treated GDM or type 1 diabetes are risk groups for overweight and the metabolic syndrome. Intrauterine hyperglycemia may in addition to genetics and other factors contribute to the pathogenesis of overweight and the metabolic syndrome.

U2 - 10.1210/jc.2009-0305

DO - 10.1210/jc.2009-0305

M3 - Journal article

C2 - 19417040

SN - 0021-972X

VL - 94

SP - 2464

EP - 2470

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 7

ER -

Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes

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