Osteoclasts prefer aged bone

K Henriksen; Diana Julie Leeming; I Byrjalsen; R H Nielsen; M G Sorensen; Morten Hanefeld Dziegiel; T John Martin; C Christiansen; P Qvist; M A Karsdal

doi:10.1007/s00198-006-0298-4

Osteoclasts prefer aged bone

K Henriksen, Diana Julie Leeming, I Byrjalsen, R H Nielsen, M G Sorensen, Morten Hanefeld Dziegiel, T John Martin, C Christiansen, P Qvist, M A Karsdal

50 Citations (Scopus)

Abstract

We investigated whether the age of the bones endogenously exerts control over the bone resorption ability of the osteoclasts, and found that osteoclasts preferentially develop and resorb bone on aged bone. These findings indicate that the bone matrix itself plays a role in targeted remodeling of aged bones.

Original language	English
Journal	Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Volume	18
Issue number	6
Pages (from-to)	751-9
Number of pages	9
ISSN	0937-941X
DOIs	https://doi.org/10.1007/s00198-006-0298-4
Publication status	Published - Jun 2007

Keywords

Acid Phosphatase
Aging
Animals
Bone Remodeling
Bone Resorption
Bone and Bones
Cattle
Cell Adhesion
Cell Differentiation
Cells, Cultured
Collagen Type I
Humans
Isoenzymes
Osteoclasts

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10.1007/s00198-006-0298-4

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Henriksen, K., Leeming, D. J., Byrjalsen, I., Nielsen, R. H., Sorensen, M. G., Dziegiel, M. H., Martin, T. J., Christiansen, C., Qvist, P., & Karsdal, M. A. (2007). Osteoclasts prefer aged bone. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 18(6), 751-9. https://doi.org/10.1007/s00198-006-0298-4

Osteoclasts prefer aged bone. / Henriksen, K; Leeming, Diana Julie; Byrjalsen, I et al.

In: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, Vol. 18, No. 6, 06.2007, p. 751-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Henriksen, K, Leeming, DJ, Byrjalsen, I, Nielsen, RH, Sorensen, MG, Dziegiel, MH, Martin, TJ, Christiansen, C, Qvist, P & Karsdal, MA 2007, 'Osteoclasts prefer aged bone', Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 18, no. 6, pp. 751-9. https://doi.org/10.1007/s00198-006-0298-4

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AU - Leeming, Diana Julie

AU - Byrjalsen, I

AU - Nielsen, R H

AU - Sorensen, M G

AU - Dziegiel, Morten Hanefeld

AU - Martin, T John

AU - Christiansen, C

AU - Qvist, P

AU - Karsdal, M A

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KW - Aging

KW - Animals

KW - Bone Remodeling

KW - Bone Resorption

KW - Bone and Bones

KW - Cattle

KW - Cell Adhesion

KW - Cell Differentiation

KW - Cells, Cultured

KW - Collagen Type I

KW - Humans

KW - Isoenzymes

KW - Osteoclasts

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SP - 751

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JO - Osteoporosis International

JF - Osteoporosis International

IS - 6

ER -

Osteoclasts prefer aged bone

Abstract

Keywords

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