Osteoclasts prefer aged bone

K Henriksen; Diana Julie Leeming; I Byrjalsen; R H Nielsen; M G Sorensen; Morten Hanefeld Dziegiel; T John Martin; C Christiansen; P Qvist; M A Karsdal

doi:10.1007/s00198-006-0298-4

Osteoclasts prefer aged bone

K Henriksen, Diana Julie Leeming, I Byrjalsen, R H Nielsen, M G Sorensen, Morten Hanefeld Dziegiel, T John Martin, C Christiansen, P Qvist, M A Karsdal

50 Citationer (Scopus)

Abstract

We investigated whether the age of the bones endogenously exerts control over the bone resorption ability of the osteoclasts, and found that osteoclasts preferentially develop and resorb bone on aged bone. These findings indicate that the bone matrix itself plays a role in targeted remodeling of aged bones.

Originalsprog	Engelsk
Tidsskrift	Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Vol/bind	18
Udgave nummer	6
Sider (fra-til)	751-9
Antal sider	9
ISSN	0937-941X
DOI	https://doi.org/10.1007/s00198-006-0298-4
Status	Udgivet - jun. 2007

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10.1007/s00198-006-0298-4

Citationsformater

Henriksen, K., Leeming, D. J., Byrjalsen, I., Nielsen, R. H., Sorensen, M. G., Dziegiel, M. H., Martin, T. J., Christiansen, C., Qvist, P., & Karsdal, M. A. (2007). Osteoclasts prefer aged bone. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 18(6), 751-9. https://doi.org/10.1007/s00198-006-0298-4

Osteoclasts prefer aged bone. / Henriksen, K; Leeming, Diana Julie; Byrjalsen, I et al.

I: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, Bind 18, Nr. 6, 06.2007, s. 751-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Henriksen, K, Leeming, DJ, Byrjalsen, I, Nielsen, RH, Sorensen, MG, Dziegiel, MH, Martin, TJ, Christiansen, C, Qvist, P & Karsdal, MA 2007, 'Osteoclasts prefer aged bone', Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, bind 18, nr. 6, s. 751-9. https://doi.org/10.1007/s00198-006-0298-4

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abstract = "We investigated whether the age of the bones endogenously exerts control over the bone resorption ability of the osteoclasts, and found that osteoclasts preferentially develop and resorb bone on aged bone. These findings indicate that the bone matrix itself plays a role in targeted remodeling of aged bones.",

keywords = "Acid Phosphatase, Aging, Animals, Bone Remodeling, Bone Resorption, Bone and Bones, Cattle, Cell Adhesion, Cell Differentiation, Cells, Cultured, Collagen Type I, Humans, Isoenzymes, Osteoclasts",

author = "K Henriksen and Leeming, {Diana Julie} and I Byrjalsen and Nielsen, {R H} and Sorensen, {M G} and Dziegiel, {Morten Hanefeld} and Martin, {T John} and C Christiansen and P Qvist and Karsdal, {M A}",

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AU - Henriksen, K

AU - Leeming, Diana Julie

AU - Byrjalsen, I

AU - Nielsen, R H

AU - Sorensen, M G

AU - Dziegiel, Morten Hanefeld

AU - Martin, T John

AU - Christiansen, C

AU - Qvist, P

AU - Karsdal, M A

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N2 - We investigated whether the age of the bones endogenously exerts control over the bone resorption ability of the osteoclasts, and found that osteoclasts preferentially develop and resorb bone on aged bone. These findings indicate that the bone matrix itself plays a role in targeted remodeling of aged bones.

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KW - Acid Phosphatase

KW - Aging

KW - Animals

KW - Bone Remodeling

KW - Bone Resorption

KW - Bone and Bones

KW - Cattle

KW - Cell Adhesion

KW - Cell Differentiation

KW - Cells, Cultured

KW - Collagen Type I

KW - Humans

KW - Isoenzymes

KW - Osteoclasts

U2 - 10.1007/s00198-006-0298-4

DO - 10.1007/s00198-006-0298-4

M3 - Journal article

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VL - 18

SP - 751

EP - 759

JO - Osteoporosis International

JF - Osteoporosis International

IS - 6

ER -

Osteoclasts prefer aged bone

Abstract

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