Oscillatory blood pressure response to the onset of cycling exercise in men: role of group III/IV muscle afferents

TY - JOUR

T1 - Oscillatory blood pressure response to the onset of cycling exercise in men

T2 - role of group III/IV muscle afferents

AU - Barbosa, Thales C

AU - Fernandes, Igor A

AU - Magalhães-Jr, Nisval

AU - Cavalcanti, Ismar L

AU - Secher, Niels H

AU - Nóbrega, Antonio C L

AU - Vianna, Lauro C

N1 - © 2015 The Authors. Experimental Physiology © 2015 The Physiological Society.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - NEW FINDINGS: What is the central question of this study? Neural feedback from group III/IV muscle afferents has a key role in regulation of cardiovascular responses to exercise. Blood pressure oscillates in the first seconds of dynamic exercise, but the contribution of muscle afferent feedback to this pattern is unclear. What is the main finding and its importance? We demonstrate that attenuation of group III/IV muscle afferent feedback by spinal fentanyl impairs the pressor response after 10 s of moderate leg cycling exercise, but this afferent feedback does not appear to be necessary for induction of the oscillatory pattern of blood pressure at the onset of exercise. We investigated whether attenuation of the central projections of group III/IV skeletal muscle afferents via lumbar intrathecal administration of the μ-opioid receptor agonist fentanyl affects the oscillatory blood pressure (BP) response to the onset of dynamic exercise. Eight healthy, recreationally active men (28 ± 3 years old) performed 40 s of cycling at 80 W (60 r.p.m.) before (control) and after fentanyl administration, while heart rate, stroke volume, cardiac output, systolic, mean and diastolic BP and total vascular conductance were continuously monitored. Sytolic and mean BP responses to cycling included an initial increase (from 0 to 3 s), followed by a transient decrease below resting levels (from 3 to 10 s) and then a sustained increase (>10 s). In the presence of fentanyl, systolic and mean BP responses closely matched those in control conditions in the first 10 s, but were blunted thereafter (P < 0.05). In contrast, fentanyl did not modify the heart rate, stroke volume, cardiac output, diastolic BP or total vascular conductance responses to 40 s of cycling (P > 0.05). These findings suggest that during moderate leg cycling exercise the muscle afferents contribute to the BP response after ∼10 s, but that they do not appear to be implicated in the oscillation of BP at the onset of exercise.

AB - NEW FINDINGS: What is the central question of this study? Neural feedback from group III/IV muscle afferents has a key role in regulation of cardiovascular responses to exercise. Blood pressure oscillates in the first seconds of dynamic exercise, but the contribution of muscle afferent feedback to this pattern is unclear. What is the main finding and its importance? We demonstrate that attenuation of group III/IV muscle afferent feedback by spinal fentanyl impairs the pressor response after 10 s of moderate leg cycling exercise, but this afferent feedback does not appear to be necessary for induction of the oscillatory pattern of blood pressure at the onset of exercise. We investigated whether attenuation of the central projections of group III/IV skeletal muscle afferents via lumbar intrathecal administration of the μ-opioid receptor agonist fentanyl affects the oscillatory blood pressure (BP) response to the onset of dynamic exercise. Eight healthy, recreationally active men (28 ± 3 years old) performed 40 s of cycling at 80 W (60 r.p.m.) before (control) and after fentanyl administration, while heart rate, stroke volume, cardiac output, systolic, mean and diastolic BP and total vascular conductance were continuously monitored. Sytolic and mean BP responses to cycling included an initial increase (from 0 to 3 s), followed by a transient decrease below resting levels (from 3 to 10 s) and then a sustained increase (>10 s). In the presence of fentanyl, systolic and mean BP responses closely matched those in control conditions in the first 10 s, but were blunted thereafter (P < 0.05). In contrast, fentanyl did not modify the heart rate, stroke volume, cardiac output, diastolic BP or total vascular conductance responses to 40 s of cycling (P > 0.05). These findings suggest that during moderate leg cycling exercise the muscle afferents contribute to the BP response after ∼10 s, but that they do not appear to be implicated in the oscillation of BP at the onset of exercise.

KW - Adult

KW - Blood Pressure

KW - Cardiac Output

KW - Exercise

KW - Fentanyl

KW - Heart Rate

KW - Humans

KW - Leg

KW - Male

KW - Muscle Fatigue

KW - Muscle, Skeletal

KW - Rest

KW - Stroke Volume

U2 - 10.1113/expphysiol.2014.083857

DO - 10.1113/expphysiol.2014.083857

M3 - Journal article

C2 - 25581883

SN - 0958-0670

VL - 100

SP - 302

EP - 311

JO - Experimental Physiology

JF - Experimental Physiology

IS - 3

ER -