Oral quercetin supplementation hampers skeletal muscle adaptations in response to exercise training

R A Casuso; E J Martínez-López; Nikolai Baastrup Nordsborg; F Hita-Contreras; R Martínez-Romero; A Cañuelo; A Martínez-Amat

doi:10.1111/sms.12136

Oral quercetin supplementation hampers skeletal muscle adaptations in response to exercise training

R A Casuso, E J Martínez-López, Nikolai Baastrup Nordsborg, F Hita-Contreras, R Martínez-Romero, A Cañuelo, A Martínez-Amat

The August Krogh Section for Human Physiology

19 Citations (Scopus)

Abstract

We aimed to test exercise-induced adaptations on skeletal muscle when quercetin is supplemented. Four groups of rats were tested: quercetin sedentary, quercetin exercised, placebo sedentary, and placebo exercised. Treadmill exercise training took place 5 days a week for 6 weeks. Quercetin groups were supplemented with quercetin, via gavage, on alternate days throughout the experimental period. Sirtuin 1 (SIRT1), peroxisome proliferator-activated receptor γ coactivator-1α mRNA levels, mitochondrial DNA (mtDNA) content, and citrate synthase (CS) activity were measured on quadriceps muscle. Redox status was also quantified by measuring muscle antioxidant enzymatic activity and oxidative damage product, such as protein carbonyl content (PCC). Quercetin supplementation increased oxidative damage in both exercised and sedentary rats by inducing higher amounts of PCC (P

Original language	English
Journal	Scandinavian Journal of Medicine & Science in Sports
Volume	24
Issue number	6
Pages (from-to)	920-927
Number of pages	8
ISSN	0905-7188
DOIs	https://doi.org/10.1111/sms.12136
Publication status	Published - 1 Dec 2014

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title = "Oral quercetin supplementation hampers skeletal muscle adaptations in response to exercise training",

abstract = "We aimed to test exercise-induced adaptations on skeletal muscle when quercetin is supplemented. Four groups of rats were tested: quercetin sedentary, quercetin exercised, placebo sedentary, and placebo exercised. Treadmill exercise training took place 5 days a week for 6 weeks. Quercetin groups were supplemented with quercetin, via gavage, on alternate days throughout the experimental period. Sirtuin 1 (SIRT1), peroxisome proliferator-activated receptor γ coactivator-1α mRNA levels, mitochondrial DNA (mtDNA) content, and citrate synthase (CS) activity were measured on quadriceps muscle. Redox status was also quantified by measuring muscle antioxidant enzymatic activity and oxidative damage product, such as protein carbonyl content (PCC). Quercetin supplementation increased oxidative damage in both exercised and sedentary rats by inducing higher amounts of PCC (P ",

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T1 - Oral quercetin supplementation hampers skeletal muscle adaptations in response to exercise training

AU - Casuso, R A

AU - Martínez-López, E J

AU - Nordsborg, Nikolai Baastrup

AU - Hita-Contreras, F

AU - Martínez-Romero, R

AU - Cañuelo, A

AU - Martínez-Amat, A

N1 - CURIS 2014 NEXS 354

PY - 2014/12/1

Y1 - 2014/12/1

N2 - We aimed to test exercise-induced adaptations on skeletal muscle when quercetin is supplemented. Four groups of rats were tested: quercetin sedentary, quercetin exercised, placebo sedentary, and placebo exercised. Treadmill exercise training took place 5 days a week for 6 weeks. Quercetin groups were supplemented with quercetin, via gavage, on alternate days throughout the experimental period. Sirtuin 1 (SIRT1), peroxisome proliferator-activated receptor γ coactivator-1α mRNA levels, mitochondrial DNA (mtDNA) content, and citrate synthase (CS) activity were measured on quadriceps muscle. Redox status was also quantified by measuring muscle antioxidant enzymatic activity and oxidative damage product, such as protein carbonyl content (PCC). Quercetin supplementation increased oxidative damage in both exercised and sedentary rats by inducing higher amounts of PCC (P

AB - We aimed to test exercise-induced adaptations on skeletal muscle when quercetin is supplemented. Four groups of rats were tested: quercetin sedentary, quercetin exercised, placebo sedentary, and placebo exercised. Treadmill exercise training took place 5 days a week for 6 weeks. Quercetin groups were supplemented with quercetin, via gavage, on alternate days throughout the experimental period. Sirtuin 1 (SIRT1), peroxisome proliferator-activated receptor γ coactivator-1α mRNA levels, mitochondrial DNA (mtDNA) content, and citrate synthase (CS) activity were measured on quadriceps muscle. Redox status was also quantified by measuring muscle antioxidant enzymatic activity and oxidative damage product, such as protein carbonyl content (PCC). Quercetin supplementation increased oxidative damage in both exercised and sedentary rats by inducing higher amounts of PCC (P

U2 - 10.1111/sms.12136

DO - 10.1111/sms.12136

M3 - Journal article

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SN - 0905-7188

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JO - Scandinavian Journal of Medicine & Science in Sports

JF - Scandinavian Journal of Medicine & Science in Sports

IS - 6

ER -

Oral quercetin supplementation hampers skeletal muscle adaptations in response to exercise training

Abstract

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