Oral quercetin supplementation hampers skeletal muscle adaptations in response to exercise training

TY - JOUR

T1 - Oral quercetin supplementation hampers skeletal muscle adaptations in response to exercise training

AU - Casuso, R A

AU - Martínez-López, E J

AU - Nordsborg, Nikolai Baastrup

AU - Hita-Contreras, F

AU - Martínez-Romero, R

AU - Cañuelo, A

AU - Martínez-Amat, A

N1 - CURIS 2014 NEXS 354

PY - 2014/12/1

Y1 - 2014/12/1

N2 - We aimed to test exercise-induced adaptations on skeletal muscle when quercetin is supplemented. Four groups of rats were tested: quercetin sedentary, quercetin exercised, placebo sedentary, and placebo exercised. Treadmill exercise training took place 5 days a week for 6 weeks. Quercetin groups were supplemented with quercetin, via gavage, on alternate days throughout the experimental period. Sirtuin 1 (SIRT1), peroxisome proliferator-activated receptor γ coactivator-1α mRNA levels, mitochondrial DNA (mtDNA) content, and citrate synthase (CS) activity were measured on quadriceps muscle. Redox status was also quantified by measuring muscle antioxidant enzymatic activity and oxidative damage product, such as protein carbonyl content (PCC). Quercetin supplementation increased oxidative damage in both exercised and sedentary rats by inducing higher amounts of PCC (P 

AB - We aimed to test exercise-induced adaptations on skeletal muscle when quercetin is supplemented. Four groups of rats were tested: quercetin sedentary, quercetin exercised, placebo sedentary, and placebo exercised. Treadmill exercise training took place 5 days a week for 6 weeks. Quercetin groups were supplemented with quercetin, via gavage, on alternate days throughout the experimental period. Sirtuin 1 (SIRT1), peroxisome proliferator-activated receptor γ coactivator-1α mRNA levels, mitochondrial DNA (mtDNA) content, and citrate synthase (CS) activity were measured on quadriceps muscle. Redox status was also quantified by measuring muscle antioxidant enzymatic activity and oxidative damage product, such as protein carbonyl content (PCC). Quercetin supplementation increased oxidative damage in both exercised and sedentary rats by inducing higher amounts of PCC (P 

U2 - 10.1111/sms.12136

DO - 10.1111/sms.12136

M3 - Journal article

C2 - 24118142

SN - 0905-7188

VL - 24

SP - 920

EP - 927

JO - Scandinavian Journal of Medicine & Science in Sports

JF - Scandinavian Journal of Medicine & Science in Sports

IS - 6

ER -