Optimization of self-microemulsifying drug delivery systems (SMEDDS) using a D-optimal design and the desirability function

R. Holm; I.H.M. Jensen; Jørn Sonnergaard

doi:10.1080/03639040600559024

Optimization of self-microemulsifying drug delivery systems (SMEDDS) using a D-optimal design and the desirability function

R. Holm, I.H.M. Jensen, Jørn Sonnergaard

54 Citations (Scopus)

Abstract

D-optimal design and the desirability function were applied to optimize a self-microemulsifying drug delivery system (SMEDDS). The optimized key parameters were the following: 1) particle size of the dispersed emulsion, 2) solubility of the drug in the vehicle, and 3) the vehicle compatibility with the hard gelatin capsule. Three formulation variables, PEG200, a surfactant mixture, and an oil mixture, were included in the experimental design. The results of the mathematical analysis of the data demonstrated significant interactions among the formulation variables, and the desirability function was demonstrated to be a powerful tool to predict the optimal formulation for the explored system.

Original language	English
Journal	Drug Development and Industrial Pharmacy
Volume	32
Issue number	9
Pages (from-to)	1025-1032
Number of pages	8
ISSN	0363-9045
DOIs	https://doi.org/10.1080/03639040600559024
Publication status	Published - 1 Oct 2006

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Optimization of self-microemulsifying drug delivery systems (SMEDDS) using a D-optimal design and the desirability function

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