TY - JOUR
T1 - Optimization of self-microemulsifying drug delivery systems (SMEDDS) using a D-optimal design and the desirability function
AU - Holm, R.
AU - Jensen, I.H.M.
AU - Sonnergaard, Jørn
PY - 2006/10/1
Y1 - 2006/10/1
N2 - D-optimal design and the desirability function were applied to optimize a self-microemulsifying drug delivery system (SMEDDS). The optimized key parameters were the following: 1) particle size of the dispersed emulsion, 2) solubility of the drug in the vehicle, and 3) the vehicle compatibility with the hard gelatin capsule. Three formulation variables, PEG200, a surfactant mixture, and an oil mixture, were included in the experimental design. The results of the mathematical analysis of the data demonstrated significant interactions among the formulation variables, and the desirability function was demonstrated to be a powerful tool to predict the optimal formulation for the explored system.
AB - D-optimal design and the desirability function were applied to optimize a self-microemulsifying drug delivery system (SMEDDS). The optimized key parameters were the following: 1) particle size of the dispersed emulsion, 2) solubility of the drug in the vehicle, and 3) the vehicle compatibility with the hard gelatin capsule. Three formulation variables, PEG200, a surfactant mixture, and an oil mixture, were included in the experimental design. The results of the mathematical analysis of the data demonstrated significant interactions among the formulation variables, and the desirability function was demonstrated to be a powerful tool to predict the optimal formulation for the explored system.
UR - http://www.scopus.com/inward/record.url?scp=33749454734&partnerID=8YFLogxK
U2 - 10.1080/03639040600559024
DO - 10.1080/03639040600559024
M3 - Journal article
C2 - 17012115
AN - SCOPUS:33749454734
SN - 0363-9045
VL - 32
SP - 1025
EP - 1032
JO - Drug Development and Industrial Pharmacy
JF - Drug Development and Industrial Pharmacy
IS - 9
ER -