Optical studies of the spectral properties of phenothiazines

Adriana  Smarandache; Jette E. Kristiansen; Jørn Bolstad Christensen; Mihail-Lucian  Pascu

doi:10.2174/157018012799859918

Optical studies of the spectral properties of phenothiazines

Adriana Smarandache, Jette E. Kristiansen, Jørn Bolstad Christensen, Mihail-Lucian Pascu

Department of Chemistry

9 Citations (Scopus)

Abstract

Literature reports show numerous studies concerning the occurrence, evolution, detection and removal of, generically, pharmaceutical pollutants in/from environment. The current report is focused on the Phenothiazines class, in particular on Thioridazine (Thr). We discuss the time evolution of the absorption spectra of Thioridazine HCl solutions in ultra-pure water considering the racemic mixture and the two enantiomers: Thioridazine (-) and Thioridazine (+); the utilized concentration range was 10 ^-5M-10 ^-3M, and the temperature/light conditions were: 4°C in dark, 22°C in dark and 22°C in daylight. The 10-5M Thr solutions were exposed at 266nm Nd:YAG pulsed laser radiation for time intervals between (1 - 3)h with the average pulse energy on the sample of 0.263mJ. Another irradiation experiment has involved Thr solutions at 5x10 ^-2M, which were irradiated for time intervals between (1 - 30)min with 355nm Nd:YAG pulsed laser beam of average pulse energy on the sample 1.45mJ. The stability studies based on the absorption spectra measurements were conducted after exposure to the laser beams. The photodegradation processes of Thr are discussed.

Original language	English
Journal	Letters in Drug Design & Discovery
Volume	9
Issue number	4
Pages (from-to)	352-360
Number of pages	9
ISSN	1570-1808
DOIs	https://doi.org/10.2174/157018012799859918
Publication status	Published - May 2012

Access to Document

10.2174/157018012799859918

Cite this

@article{43cbc94a372a46a2b5220eb1a707f563,

title = "Optical studies of the spectral properties of phenothiazines",

abstract = "Literature reports show numerous studies concerning the occurrence, evolution, detection and removal of, generically, pharmaceutical pollutants in/from environment. The current report is focused on the Phenothiazines class, in particular on Thioridazine (Thr). We discuss the time evolution of the absorption spectra of Thioridazine HCl solutions in ultra-pure water considering the racemic mixture and the two enantiomers: Thioridazine (-) and Thioridazine (+); the utilized concentration range was 10 -5M-10 -3M, and the temperature/light conditions were: 4°C in dark, 22°C in dark and 22°C in daylight. The 10-5M Thr solutions were exposed at 266nm Nd:YAG pulsed laser radiation for time intervals between (1 - 3)h with the average pulse energy on the sample of 0.263mJ. Another irradiation experiment has involved Thr solutions at 5x10 -2M, which were irradiated for time intervals between (1 - 30)min with 355nm Nd:YAG pulsed laser beam of average pulse energy on the sample 1.45mJ. The stability studies based on the absorption spectra measurements were conducted after exposure to the laser beams. The photodegradation processes of Thr are discussed.",

author = "Adriana Smarandache and Kristiansen, {Jette E.} and Christensen, {J{\o}rn Bolstad} and Mihail-Lucian Pascu",

year = "2012",

month = may,

doi = "10.2174/157018012799859918",

language = "English",

volume = "9",

pages = "352--360",

journal = "Letters in Drug Design & Discovery",

issn = "1570-1808",

publisher = "Bentham Science Publishers",

number = "4",

}

TY - JOUR

T1 - Optical studies of the spectral properties of phenothiazines

AU - Smarandache, Adriana

AU - Kristiansen, Jette E.

AU - Christensen, Jørn Bolstad

AU - Pascu, Mihail-Lucian

PY - 2012/5

Y1 - 2012/5

N2 - Literature reports show numerous studies concerning the occurrence, evolution, detection and removal of, generically, pharmaceutical pollutants in/from environment. The current report is focused on the Phenothiazines class, in particular on Thioridazine (Thr). We discuss the time evolution of the absorption spectra of Thioridazine HCl solutions in ultra-pure water considering the racemic mixture and the two enantiomers: Thioridazine (-) and Thioridazine (+); the utilized concentration range was 10 -5M-10 -3M, and the temperature/light conditions were: 4°C in dark, 22°C in dark and 22°C in daylight. The 10-5M Thr solutions were exposed at 266nm Nd:YAG pulsed laser radiation for time intervals between (1 - 3)h with the average pulse energy on the sample of 0.263mJ. Another irradiation experiment has involved Thr solutions at 5x10 -2M, which were irradiated for time intervals between (1 - 30)min with 355nm Nd:YAG pulsed laser beam of average pulse energy on the sample 1.45mJ. The stability studies based on the absorption spectra measurements were conducted after exposure to the laser beams. The photodegradation processes of Thr are discussed.

AB - Literature reports show numerous studies concerning the occurrence, evolution, detection and removal of, generically, pharmaceutical pollutants in/from environment. The current report is focused on the Phenothiazines class, in particular on Thioridazine (Thr). We discuss the time evolution of the absorption spectra of Thioridazine HCl solutions in ultra-pure water considering the racemic mixture and the two enantiomers: Thioridazine (-) and Thioridazine (+); the utilized concentration range was 10 -5M-10 -3M, and the temperature/light conditions were: 4°C in dark, 22°C in dark and 22°C in daylight. The 10-5M Thr solutions were exposed at 266nm Nd:YAG pulsed laser radiation for time intervals between (1 - 3)h with the average pulse energy on the sample of 0.263mJ. Another irradiation experiment has involved Thr solutions at 5x10 -2M, which were irradiated for time intervals between (1 - 30)min with 355nm Nd:YAG pulsed laser beam of average pulse energy on the sample 1.45mJ. The stability studies based on the absorption spectra measurements were conducted after exposure to the laser beams. The photodegradation processes of Thr are discussed.

U2 - 10.2174/157018012799859918

DO - 10.2174/157018012799859918

M3 - Journal article

SN - 1570-1808

VL - 9

SP - 352

EP - 360

JO - Letters in Drug Design & Discovery

JF - Letters in Drug Design & Discovery

IS - 4

ER -

Optical studies of the spectral properties of phenothiazines

Abstract

Access to Document

Fingerprint

Cite this