TY - JOUR
T1 - Optical studies of the spectral properties of phenothiazines
AU - Smarandache, Adriana
AU - Kristiansen, Jette E.
AU - Christensen, Jørn Bolstad
AU - Pascu, Mihail-Lucian
PY - 2012/5
Y1 - 2012/5
N2 - Literature reports show numerous studies concerning the occurrence, evolution, detection and removal of, generically, pharmaceutical pollutants in/from environment. The current report is focused on the Phenothiazines class, in particular on Thioridazine (Thr). We discuss the time evolution of the absorption spectra of Thioridazine HCl solutions in ultra-pure water considering the racemic mixture and the two enantiomers: Thioridazine (-) and Thioridazine (+); the utilized concentration range was 10 -5M-10 -3M, and the temperature/light conditions were: 4°C in dark, 22°C in dark and 22°C in daylight. The 10-5M Thr solutions were exposed at 266nm Nd:YAG pulsed laser radiation for time intervals between (1 - 3)h with the average pulse energy on the sample of 0.263mJ. Another irradiation experiment has involved Thr solutions at 5x10 -2M, which were irradiated for time intervals between (1 - 30)min with 355nm Nd:YAG pulsed laser beam of average pulse energy on the sample 1.45mJ. The stability studies based on the absorption spectra measurements were conducted after exposure to the laser beams. The photodegradation processes of Thr are discussed.
AB - Literature reports show numerous studies concerning the occurrence, evolution, detection and removal of, generically, pharmaceutical pollutants in/from environment. The current report is focused on the Phenothiazines class, in particular on Thioridazine (Thr). We discuss the time evolution of the absorption spectra of Thioridazine HCl solutions in ultra-pure water considering the racemic mixture and the two enantiomers: Thioridazine (-) and Thioridazine (+); the utilized concentration range was 10 -5M-10 -3M, and the temperature/light conditions were: 4°C in dark, 22°C in dark and 22°C in daylight. The 10-5M Thr solutions were exposed at 266nm Nd:YAG pulsed laser radiation for time intervals between (1 - 3)h with the average pulse energy on the sample of 0.263mJ. Another irradiation experiment has involved Thr solutions at 5x10 -2M, which were irradiated for time intervals between (1 - 30)min with 355nm Nd:YAG pulsed laser beam of average pulse energy on the sample 1.45mJ. The stability studies based on the absorption spectra measurements were conducted after exposure to the laser beams. The photodegradation processes of Thr are discussed.
U2 - 10.2174/157018012799859918
DO - 10.2174/157018012799859918
M3 - Journal article
SN - 1570-1808
VL - 9
SP - 352
EP - 360
JO - Letters in Drug Design & Discovery
JF - Letters in Drug Design & Discovery
IS - 4
ER -