One-year mortality in coagulase-negative Staphylococcus and Staphylococcus aureus infective endocarditis

Rasmus V Rasmussen; Ulrika Snygg-Martin; Lars Olaison; Rune Andersson; Kristine Buchholtz; Carsten T Larsen; Thomas F Hansen; Lars Køber; Christian Hassager; Niels E Bruun; Rasmus V Rasmussen; Ulrika Snygg-Martin; Lars Olaison; Rune Andersson; Kristine Buchholtz; Carsten T Larsen; Thomas Fritz Hansen; Lars Køber; Christian Hassager; Niels E Bruun

doi:10.1080/00365540902896061

One-year mortality in coagulase-negative Staphylococcus and Staphylococcus aureus infective endocarditis

Rasmus V Rasmussen, Ulrika Snygg-Martin, Lars Olaison, Rune Andersson, Kristine Buchholtz, Carsten T Larsen, Thomas F Hansen, Lars Køber, Christian Hassager, Niels E Bruun, Rasmus V Rasmussen, Ulrika Snygg-Martin, Lars Olaison, Rune Andersson, Kristine Buchholtz, Carsten T Larsen, Thomas Fritz Hansen, Lars Køber, Christian Hassager, Niels E Bruun

7 Citations (Scopus)

Abstract

The aim of this study was to investigate in-hospital mortality and 12-month mortality in patients with coagulase-negative Staphylococcus (CoNS) compared to Staphylococcus aureus (S. aureus) infective endocarditis (IE). We used a prospective cohort study of 66 consecutive CoNS and 170 S. aureus IE patients, collected at 2 tertiary university hospitals in Copenhagen (Denmark) and at 1 tertiary university hospital in Gothenburg (Sweden). Median (range) C-reactive protein at admission was higher in patients with S. aureus IE (150 mg/l (1-521) vs 94 mg/l (6-303); p<0.001), which may suggest a more serous infection. CoNS was associated with prosthetic valve IE (49% vs 24%; p<0.001) and median diagnostic delay was longer in CoNS IE patients (20 d (0-232) vs 9 d (0-132); p<0.001). In-hospital mortality was equally high in both groups but 25% of the CoNS IE patients had died after 1 y compared to 39% of patients with S. aureus IE (p =0.05). In conclusion, CoNS IE was associated with a long diagnostic delay and high in-hospital mortality, whereas post-discharge prognosis was better in this group of patients compared to patients with IE due to S. aureus.

Original language	English
Book series	Scandinavian Journal of Infectious Diseases. Supplementum
Volume	41
Issue number	6-7
Pages (from-to)	456-61
Number of pages	6
ISSN	0300-8878
DOIs	https://doi.org/10.1080/00365540902896061 https://doi.org/10.1080/00365540902896061
Publication status	Published - 1 Jan 2009

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Rasmussen, R. V., Snygg-Martin, U., Olaison, L., Andersson, R., Buchholtz, K., Larsen, C. T., Hansen, T. F., Køber, L., Hassager, C., Bruun, N. E., Rasmussen, R. V., Snygg-Martin, U., Olaison, L., Andersson, R., Buchholtz, K., Larsen, C. T., Hansen, T. F., Køber, L., Hassager, C., & Bruun, N. E. (2009). One-year mortality in coagulase-negative Staphylococcus and Staphylococcus aureus infective endocarditis. Scandinavian Journal of Infectious Diseases. Supplementum, 41(6-7), 456-61. https://doi.org/10.1080/00365540902896061, https://doi.org/10.1080/00365540902896061

Rasmussen, RV, Snygg-Martin, U, Olaison, L, Andersson, R, Buchholtz, K, Larsen, CT, Hansen, TF, Køber, L , Hassager, C , Bruun, NE, Rasmussen, RV, Snygg-Martin, U, Olaison, L, Andersson, R, Buchholtz, K, Larsen, CT, Hansen, TF, Køber, L, Hassager, C & Bruun, NE 2009, 'One-year mortality in coagulase-negative Staphylococcus and Staphylococcus aureus infective endocarditis', Scandinavian Journal of Infectious Diseases. Supplementum, vol. 41, no. 6-7, pp. 456-61. https://doi.org/10.1080/00365540902896061, https://doi.org/10.1080/00365540902896061

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title = "One-year mortality in coagulase-negative Staphylococcus and Staphylococcus aureus infective endocarditis",

abstract = "The aim of this study was to investigate in-hospital mortality and 12-month mortality in patients with coagulase-negative Staphylococcus (CoNS) compared to Staphylococcus aureus (S. aureus) infective endocarditis (IE). We used a prospective cohort study of 66 consecutive CoNS and 170 S. aureus IE patients, collected at 2 tertiary university hospitals in Copenhagen (Denmark) and at 1 tertiary university hospital in Gothenburg (Sweden). Median (range) C-reactive protein at admission was higher in patients with S. aureus IE (150 mg/l (1-521) vs 94 mg/l (6-303); p<0.001), which may suggest a more serous infection. CoNS was associated with prosthetic valve IE (49% vs 24%; p<0.001) and median diagnostic delay was longer in CoNS IE patients (20 d (0-232) vs 9 d (0-132); p<0.001). In-hospital mortality was equally high in both groups but 25% of the CoNS IE patients had died after 1 y compared to 39% of patients with S. aureus IE (p =0.05). In conclusion, CoNS IE was associated with a long diagnostic delay and high in-hospital mortality, whereas post-discharge prognosis was better in this group of patients compared to patients with IE due to S. aureus.",

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AU - Rasmussen, Rasmus V

AU - Snygg-Martin, Ulrika

AU - Olaison, Lars

AU - Andersson, Rune

AU - Buchholtz, Kristine

AU - Larsen, Carsten T

AU - Hansen, Thomas F

AU - Køber, Lars

AU - Hassager, Christian

AU - Bruun, Niels E

AU - Rasmussen, Rasmus V

AU - Snygg-Martin, Ulrika

AU - Olaison, Lars

AU - Andersson, Rune

AU - Buchholtz, Kristine

AU - Larsen, Carsten T

AU - Hansen, Thomas Fritz

AU - Køber, Lars

AU - Hassager, Christian

AU - Bruun, Niels E

PY - 2009/1/1

Y1 - 2009/1/1

N2 - The aim of this study was to investigate in-hospital mortality and 12-month mortality in patients with coagulase-negative Staphylococcus (CoNS) compared to Staphylococcus aureus (S. aureus) infective endocarditis (IE). We used a prospective cohort study of 66 consecutive CoNS and 170 S. aureus IE patients, collected at 2 tertiary university hospitals in Copenhagen (Denmark) and at 1 tertiary university hospital in Gothenburg (Sweden). Median (range) C-reactive protein at admission was higher in patients with S. aureus IE (150 mg/l (1-521) vs 94 mg/l (6-303); p<0.001), which may suggest a more serous infection. CoNS was associated with prosthetic valve IE (49% vs 24%; p<0.001) and median diagnostic delay was longer in CoNS IE patients (20 d (0-232) vs 9 d (0-132); p<0.001). In-hospital mortality was equally high in both groups but 25% of the CoNS IE patients had died after 1 y compared to 39% of patients with S. aureus IE (p =0.05). In conclusion, CoNS IE was associated with a long diagnostic delay and high in-hospital mortality, whereas post-discharge prognosis was better in this group of patients compared to patients with IE due to S. aureus.

AB - The aim of this study was to investigate in-hospital mortality and 12-month mortality in patients with coagulase-negative Staphylococcus (CoNS) compared to Staphylococcus aureus (S. aureus) infective endocarditis (IE). We used a prospective cohort study of 66 consecutive CoNS and 170 S. aureus IE patients, collected at 2 tertiary university hospitals in Copenhagen (Denmark) and at 1 tertiary university hospital in Gothenburg (Sweden). Median (range) C-reactive protein at admission was higher in patients with S. aureus IE (150 mg/l (1-521) vs 94 mg/l (6-303); p<0.001), which may suggest a more serous infection. CoNS was associated with prosthetic valve IE (49% vs 24%; p<0.001) and median diagnostic delay was longer in CoNS IE patients (20 d (0-232) vs 9 d (0-132); p<0.001). In-hospital mortality was equally high in both groups but 25% of the CoNS IE patients had died after 1 y compared to 39% of patients with S. aureus IE (p =0.05). In conclusion, CoNS IE was associated with a long diagnostic delay and high in-hospital mortality, whereas post-discharge prognosis was better in this group of patients compared to patients with IE due to S. aureus.

U2 - 10.1080/00365540902896061

DO - 10.1080/00365540902896061

M3 - Journal article

C2 - 19396665

SN - 0300-8878

VL - 41

SP - 456

EP - 461

JO - Scandinavian Journal of Infectious Diseases, Supplement

JF - Scandinavian Journal of Infectious Diseases, Supplement

IS - 6-7

ER -

One-year mortality in coagulase-negative Staphylococcus and Staphylococcus aureus infective endocarditis

Abstract

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