Onconeural Antibodies in Acute Psychiatric Inpatient Care

Sverre Georg Sæther; Morten Schou; Winfried Stoecker; Bianca Teegen; Kathrin Borowski; Arne Vaaler; Daniel Kondziella; Solveig Klæbo Reitan

doi:10.1176/appi.neuropsych.16050110

Onconeural Antibodies in Acute Psychiatric Inpatient Care

Sverre Georg Sæther, Morten Schou, Winfried Stoecker, Bianca Teegen, Kathrin Borowski, Arne Vaaler, Daniel Kondziella, Solveig Klæbo Reitan

Department of Clinical Medicine

5 Citations (Scopus)

Abstract

Paraneoplastic neurological disorders associated with onconeural antibodies often appear with neuropsychiatric symptoms. To study the prevalence of onconeural antibodies in patients admitted to acute psychiatric inpatient care, the serum of 585 such patients was tested for antibodies targeting MOG, GLRA1B, DPPX, GRM1, GRM5, DNER, Yo, ZIC4, GAD67, amphiphysin, CV2, Hu, Ri, Ma2, and recoverin. Only one sample was positive (antirecoverin IgG). The present findings suggest that serum onconeural antibody positivity is rare among patients acutely admitted for inpatient psychiatric care. The clinical implications of this finding are discussed.

Original language	English
Journal	The Journal of Neuropsychiatry and Clinical Neurosciences
Volume	29
Issue number	1
Pages (from-to)	74-76
ISSN	0895-0172
DOIs	https://doi.org/10.1176/appi.neuropsych.16050110
Publication status	Published - 2017

Keywords

Acute Disease
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Neoplasm/blood
Blood Chemical Analysis
Cross-Sectional Studies
Female
Hospitals, Psychiatric
Hospitals, University
Humans
Inpatients
Male
Mental Disorders/epidemiology
Middle Aged
Paraneoplastic Syndromes, Nervous System/epidemiology
Prevalence
Protein Array Analysis
Retrospective Studies
Young Adult

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10.1176/appi.neuropsych.16050110

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title = "Onconeural Antibodies in Acute Psychiatric Inpatient Care",

abstract = "Paraneoplastic neurological disorders associated with onconeural antibodies often appear with neuropsychiatric symptoms. To study the prevalence of onconeural antibodies in patients admitted to acute psychiatric inpatient care, the serum of 585 such patients was tested for antibodies targeting MOG, GLRA1B, DPPX, GRM1, GRM5, DNER, Yo, ZIC4, GAD67, amphiphysin, CV2, Hu, Ri, Ma2, and recoverin. Only one sample was positive (antirecoverin IgG). The present findings suggest that serum onconeural antibody positivity is rare among patients acutely admitted for inpatient psychiatric care. The clinical implications of this finding are discussed.",

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T1 - Onconeural Antibodies in Acute Psychiatric Inpatient Care

AU - Sæther, Sverre Georg

AU - Schou, Morten

AU - Stoecker, Winfried

AU - Teegen, Bianca

AU - Borowski, Kathrin

AU - Vaaler, Arne

AU - Kondziella, Daniel

AU - Reitan, Solveig Klæbo

PY - 2017

Y1 - 2017

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AB - Paraneoplastic neurological disorders associated with onconeural antibodies often appear with neuropsychiatric symptoms. To study the prevalence of onconeural antibodies in patients admitted to acute psychiatric inpatient care, the serum of 585 such patients was tested for antibodies targeting MOG, GLRA1B, DPPX, GRM1, GRM5, DNER, Yo, ZIC4, GAD67, amphiphysin, CV2, Hu, Ri, Ma2, and recoverin. Only one sample was positive (antirecoverin IgG). The present findings suggest that serum onconeural antibody positivity is rare among patients acutely admitted for inpatient psychiatric care. The clinical implications of this finding are discussed.

KW - Acute Disease

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

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KW - Blood Chemical Analysis

KW - Cross-Sectional Studies

KW - Female

KW - Hospitals, Psychiatric

KW - Hospitals, University

KW - Humans

KW - Inpatients

KW - Male

KW - Mental Disorders/epidemiology

KW - Middle Aged

KW - Paraneoplastic Syndromes, Nervous System/epidemiology

KW - Prevalence

KW - Protein Array Analysis

KW - Retrospective Studies

KW - Young Adult

U2 - 10.1176/appi.neuropsych.16050110

DO - 10.1176/appi.neuropsych.16050110

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SN - 0895-0172

VL - 29

SP - 74

EP - 76

JO - The Journal of Neuropsychiatry and Clinical Neurosciences

JF - The Journal of Neuropsychiatry and Clinical Neurosciences

IS - 1

ER -

Onconeural Antibodies in Acute Psychiatric Inpatient Care

Abstract

Keywords

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