Onconeural Antibodies in Acute Psychiatric Inpatient Care

Sverre Georg Sæther; Morten Schou; Winfried Stoecker; Bianca Teegen; Kathrin Borowski; Arne Vaaler; Daniel Kondziella; Solveig Klæbo Reitan

doi:10.1176/appi.neuropsych.16050110

Onconeural Antibodies in Acute Psychiatric Inpatient Care

Sverre Georg Sæther, Morten Schou, Winfried Stoecker, Bianca Teegen, Kathrin Borowski, Arne Vaaler, Daniel Kondziella, Solveig Klæbo Reitan

Institut for Klinisk Medicin

5 Citationer (Scopus)

Abstract

Paraneoplastic neurological disorders associated with onconeural antibodies often appear with neuropsychiatric symptoms. To study the prevalence of onconeural antibodies in patients admitted to acute psychiatric inpatient care, the serum of 585 such patients was tested for antibodies targeting MOG, GLRA1B, DPPX, GRM1, GRM5, DNER, Yo, ZIC4, GAD67, amphiphysin, CV2, Hu, Ri, Ma2, and recoverin. Only one sample was positive (antirecoverin IgG). The present findings suggest that serum onconeural antibody positivity is rare among patients acutely admitted for inpatient psychiatric care. The clinical implications of this finding are discussed.

Originalsprog	Engelsk
Tidsskrift	The Journal of Neuropsychiatry and Clinical Neurosciences
Vol/bind	29
Udgave nummer	1
Sider (fra-til)	74-76
ISSN	0895-0172
DOI	https://doi.org/10.1176/appi.neuropsych.16050110
Status	Udgivet - 2017

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10.1176/appi.neuropsych.16050110

appi.neuropsych.16050110Forlagets udgivne version, 435 KB

Citationsformater

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title = "Onconeural Antibodies in Acute Psychiatric Inpatient Care",

abstract = "Paraneoplastic neurological disorders associated with onconeural antibodies often appear with neuropsychiatric symptoms. To study the prevalence of onconeural antibodies in patients admitted to acute psychiatric inpatient care, the serum of 585 such patients was tested for antibodies targeting MOG, GLRA1B, DPPX, GRM1, GRM5, DNER, Yo, ZIC4, GAD67, amphiphysin, CV2, Hu, Ri, Ma2, and recoverin. Only one sample was positive (antirecoverin IgG). The present findings suggest that serum onconeural antibody positivity is rare among patients acutely admitted for inpatient psychiatric care. The clinical implications of this finding are discussed.",

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author = "S{\ae}ther, {Sverre Georg} and Morten Schou and Winfried Stoecker and Bianca Teegen and Kathrin Borowski and Arne Vaaler and Daniel Kondziella and Reitan, {Solveig Kl{\ae}bo}",

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language = "English",

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T1 - Onconeural Antibodies in Acute Psychiatric Inpatient Care

AU - Sæther, Sverre Georg

AU - Schou, Morten

AU - Stoecker, Winfried

AU - Teegen, Bianca

AU - Borowski, Kathrin

AU - Vaaler, Arne

AU - Kondziella, Daniel

AU - Reitan, Solveig Klæbo

PY - 2017

Y1 - 2017

N2 - Paraneoplastic neurological disorders associated with onconeural antibodies often appear with neuropsychiatric symptoms. To study the prevalence of onconeural antibodies in patients admitted to acute psychiatric inpatient care, the serum of 585 such patients was tested for antibodies targeting MOG, GLRA1B, DPPX, GRM1, GRM5, DNER, Yo, ZIC4, GAD67, amphiphysin, CV2, Hu, Ri, Ma2, and recoverin. Only one sample was positive (antirecoverin IgG). The present findings suggest that serum onconeural antibody positivity is rare among patients acutely admitted for inpatient psychiatric care. The clinical implications of this finding are discussed.

AB - Paraneoplastic neurological disorders associated with onconeural antibodies often appear with neuropsychiatric symptoms. To study the prevalence of onconeural antibodies in patients admitted to acute psychiatric inpatient care, the serum of 585 such patients was tested for antibodies targeting MOG, GLRA1B, DPPX, GRM1, GRM5, DNER, Yo, ZIC4, GAD67, amphiphysin, CV2, Hu, Ri, Ma2, and recoverin. Only one sample was positive (antirecoverin IgG). The present findings suggest that serum onconeural antibody positivity is rare among patients acutely admitted for inpatient psychiatric care. The clinical implications of this finding are discussed.

KW - Acute Disease

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Antibodies, Neoplasm/blood

KW - Blood Chemical Analysis

KW - Cross-Sectional Studies

KW - Female

KW - Hospitals, Psychiatric

KW - Hospitals, University

KW - Humans

KW - Inpatients

KW - Male

KW - Mental Disorders/epidemiology

KW - Middle Aged

KW - Paraneoplastic Syndromes, Nervous System/epidemiology

KW - Prevalence

KW - Protein Array Analysis

KW - Retrospective Studies

KW - Young Adult

U2 - 10.1176/appi.neuropsych.16050110

DO - 10.1176/appi.neuropsych.16050110

M3 - Journal article

C2 - 27578448

SN - 0895-0172

VL - 29

SP - 74

EP - 76

JO - The Journal of Neuropsychiatry and Clinical Neurosciences

JF - The Journal of Neuropsychiatry and Clinical Neurosciences

IS - 1

ER -

Onconeural Antibodies in Acute Psychiatric Inpatient Care

Abstract

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