Oct4: the final frontier, differentiation defining pluripotency

Alessandra Livigni; Joshua M Brickman

doi:10.1016/j.devcel.2013.06.002

Oct4: the final frontier, differentiation defining pluripotency

Alessandra Livigni, Joshua M Brickman

Stem Cell and developmental Biology - early embryonic lineage specification Lab

5 Citations (Scopus)

Abstract

The transcription factor OCT4 is a cornerstone of pluripotency, and yet OCT4 has also been associated with differentiation in a number of contexts. Reporting in this issue of Developmental Cell, Frum et al. (2013) show that OCT4's major early activity in the blastocyst is to support primitive endoderm differentiation.

Original language	English
Journal	Developmental Cell
Volume	25
Issue number	6
Pages (from-to)	547-8
Number of pages	2
DOIs	https://doi.org/10.1016/j.devcel.2013.06.002
Publication status	Published - 24 Jun 2013

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10.1016/j.devcel.2013.06.002

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title = "Oct4: the final frontier, differentiation defining pluripotency",

abstract = "The transcription factor OCT4 is a cornerstone of pluripotency, and yet OCT4 has also been associated with differentiation in a number of contexts. Reporting in this issue of Developmental Cell, Frum et al. (2013) show that OCT4's major early activity in the blastocyst is to support primitive endoderm differentiation.",

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AB - The transcription factor OCT4 is a cornerstone of pluripotency, and yet OCT4 has also been associated with differentiation in a number of contexts. Reporting in this issue of Developmental Cell, Frum et al. (2013) show that OCT4's major early activity in the blastocyst is to support primitive endoderm differentiation.

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DO - 10.1016/j.devcel.2013.06.002

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Oct4: the final frontier, differentiation defining pluripotency

Abstract

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