Notch and Wnt signaling in the emergence of hematopoietic stem cells

Anna Bigas; Jordi Guiu; Leonor Gama-Norton

doi:10.1016/j.bcmd.2013.07.005

Notch and Wnt signaling in the emergence of hematopoietic stem cells

Anna Bigas^*, Jordi Guiu, Leonor Gama-Norton

^*Corresponding author for this work

43 Citations (Scopus)

Abstract

Hematopoietic stem cells (HSC), which reside in the marrow of adult mammals and sustain hematopoiesis for the lifetime of the organism, are specified and generated during embryonic development. We are just beginning to understand how HSC develop from more primitive cells and the complexity of the signaling pathways involved. In this work, we review the role of two crucial pathways, Notch and Wnt, in the specification and development of HSC and their nascent microenvironment, the arterial vessels.

Original language	English
Journal	Blood Cells, Molecules, and Diseases
Volume	51
Issue number	4
Pages (from-to)	264-270
Number of pages	7
ISSN	1079-9796
DOIs	https://doi.org/10.1016/j.bcmd.2013.07.005
Publication status	Published - 1 Dec 2013
Externally published	Yes

Keywords

AGM
Embryonic hematopoiesis
Hematopoiesis
HSC
Notch
Wnt

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10.1016/j.bcmd.2013.07.005

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KW - Hematopoiesis

KW - HSC

KW - Notch

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Notch and Wnt signaling in the emergence of hematopoietic stem cells

Abstract

Keywords

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