Notch and Wnt signaling in the emergence of hematopoietic stem cells

TY - JOUR

T1 - Notch and Wnt signaling in the emergence of hematopoietic stem cells

AU - Bigas, Anna

AU - Guiu, Jordi

AU - Gama-Norton, Leonor

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Hematopoietic stem cells (HSC), which reside in the marrow of adult mammals and sustain hematopoiesis for the lifetime of the organism, are specified and generated during embryonic development. We are just beginning to understand how HSC develop from more primitive cells and the complexity of the signaling pathways involved. In this work, we review the role of two crucial pathways, Notch and Wnt, in the specification and development of HSC and their nascent microenvironment, the arterial vessels.

AB - Hematopoietic stem cells (HSC), which reside in the marrow of adult mammals and sustain hematopoiesis for the lifetime of the organism, are specified and generated during embryonic development. We are just beginning to understand how HSC develop from more primitive cells and the complexity of the signaling pathways involved. In this work, we review the role of two crucial pathways, Notch and Wnt, in the specification and development of HSC and their nascent microenvironment, the arterial vessels.

KW - AGM

KW - Embryonic hematopoiesis

KW - Hematopoiesis

KW - HSC

KW - Notch

KW - Wnt

UR - http://www.scopus.com/inward/record.url?scp=84886308051&partnerID=8YFLogxK

U2 - 10.1016/j.bcmd.2013.07.005

DO - 10.1016/j.bcmd.2013.07.005

M3 - Journal article

C2 - 23927968

AN - SCOPUS:84886308051

SN - 1079-9796

VL - 51

SP - 264

EP - 270

JO - Blood Cells, Molecules, and Diseases

JF - Blood Cells, Molecules, and Diseases

IS - 4

ER -