Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes

Camilla Helene Sandholt; Mette S Mogensen; Knut Borch-Johnsen; Annelli Sandbaek; Torsten Lauritzen; Thorkild I A Sørensen; Lars Hansen; Katrine Almind; Torben Jørgensen; Oluf Pedersen; Torben Hansen

doi:10.1371/journal.pone.0002872

Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes

Camilla Helene Sandholt, Mette S Mogensen, Knut Borch-Johnsen, Annelli Sandbaek, Torsten Lauritzen, Thorkild I A Sørensen, Lars Hansen, Katrine Almind, Torben Jørgensen, Oluf Pedersen, Torben Hansen

Department of Public Health

37 Citations (Scopus)

Abstract

The INSIG2 rs7566605 and PFKP rs6602024 polymorphisms have been identified as obesity gene variants in genome-wide association (GWA) studies. However, replication has been contradictory for both variants. The aims of this study were to validate these obesity-associations through case-control studies and analyses of obesity-related quantitative traits. Moreover, since environmental and genetic factors may modulate the impact of a genetic variant, we wanted to perform such interaction analyses. We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (rs9939609) and near MC4R (rs17782313) as genetic risk factors.

Original language	English
Journal	PLoS ONE
Volume	3
Issue number	8
Pages (from-to)	e2872
Number of pages	6
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0002872
Publication status	Published - 2008

Keywords

Blood Platelets
DNA Replication
Denmark
Exercise
Female
Genetic Variation
Genome, Human
Genotype
Humans
Intracellular Signaling Peptides and Proteins
Male
Membrane Proteins
Motor Activity
Obesity
Overweight
Phosphofructokinases
Polymorphism, Genetic

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0002872

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Sandholt, C. H., Mogensen, M. S., Borch-Johnsen, K., Sandbaek, A., Lauritzen, T., Sørensen, T. I. A., Hansen, L., Almind, K., Jørgensen, T., Pedersen, O., & Hansen, T. (2008). Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes. PLoS ONE, 3(8), e2872. https://doi.org/10.1371/journal.pone.0002872

Sandholt, CH, Mogensen, MS, Borch-Johnsen, K, Sandbaek, A, Lauritzen, T, Sørensen, TIA, Hansen, L, Almind, K, Jørgensen, T, Pedersen, O & Hansen, T 2008, 'Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes', PLoS ONE, vol. 3, no. 8, pp. e2872. https://doi.org/10.1371/journal.pone.0002872

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title = "Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes",

abstract = "The INSIG2 rs7566605 and PFKP rs6602024 polymorphisms have been identified as obesity gene variants in genome-wide association (GWA) studies. However, replication has been contradictory for both variants. The aims of this study were to validate these obesity-associations through case-control studies and analyses of obesity-related quantitative traits. Moreover, since environmental and genetic factors may modulate the impact of a genetic variant, we wanted to perform such interaction analyses. We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (rs9939609) and near MC4R (rs17782313) as genetic risk factors.",

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AU - Sandholt, Camilla Helene

AU - Mogensen, Mette S

AU - Borch-Johnsen, Knut

AU - Sandbaek, Annelli

AU - Lauritzen, Torsten

AU - Sørensen, Thorkild I A

AU - Hansen, Lars

AU - Almind, Katrine

AU - Jørgensen, Torben

AU - Pedersen, Oluf

AU - Hansen, Torben

PY - 2008

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N2 - The INSIG2 rs7566605 and PFKP rs6602024 polymorphisms have been identified as obesity gene variants in genome-wide association (GWA) studies. However, replication has been contradictory for both variants. The aims of this study were to validate these obesity-associations through case-control studies and analyses of obesity-related quantitative traits. Moreover, since environmental and genetic factors may modulate the impact of a genetic variant, we wanted to perform such interaction analyses. We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (rs9939609) and near MC4R (rs17782313) as genetic risk factors.

AB - The INSIG2 rs7566605 and PFKP rs6602024 polymorphisms have been identified as obesity gene variants in genome-wide association (GWA) studies. However, replication has been contradictory for both variants. The aims of this study were to validate these obesity-associations through case-control studies and analyses of obesity-related quantitative traits. Moreover, since environmental and genetic factors may modulate the impact of a genetic variant, we wanted to perform such interaction analyses. We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (rs9939609) and near MC4R (rs17782313) as genetic risk factors.

KW - Blood Platelets

KW - DNA Replication

KW - Denmark

KW - Exercise

KW - Female

KW - Genetic Variation

KW - Genome, Human

KW - Genotype

KW - Humans

KW - Intracellular Signaling Peptides and Proteins

KW - Male

KW - Membrane Proteins

KW - Motor Activity

KW - Obesity

KW - Overweight

KW - Phosphofructokinases

KW - Polymorphism, Genetic

U2 - 10.1371/journal.pone.0002872

DO - 10.1371/journal.pone.0002872

M3 - Journal article

C2 - 18682847

SN - 1932-6203

VL - 3

SP - e2872

JO - PLoS ONE

JF - PLoS ONE

IS - 8

ER -

Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes

Abstract

Keywords

UN SDGs

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