Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes

Camilla Helene Sandholt; Mette S Mogensen; Knut Borch-Johnsen; Annelli Sandbaek; Torsten Lauritzen; Thorkild I A Sørensen; Lars Hansen; Katrine Almind; Torben Jørgensen; Oluf Pedersen; Torben Hansen

doi:10.1371/journal.pone.0002872

Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes

Camilla Helene Sandholt, Mette S Mogensen, Knut Borch-Johnsen, Annelli Sandbaek, Torsten Lauritzen, Thorkild I A Sørensen, Lars Hansen, Katrine Almind, Torben Jørgensen, Oluf Pedersen, Torben Hansen

Institut for Folkesundhedsvidenskab

37 Citationer (Scopus)

Abstract

The INSIG2 rs7566605 and PFKP rs6602024 polymorphisms have been identified as obesity gene variants in genome-wide association (GWA) studies. However, replication has been contradictory for both variants. The aims of this study were to validate these obesity-associations through case-control studies and analyses of obesity-related quantitative traits. Moreover, since environmental and genetic factors may modulate the impact of a genetic variant, we wanted to perform such interaction analyses. We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (rs9939609) and near MC4R (rs17782313) as genetic risk factors.

Originalsprog	Engelsk
Tidsskrift	PLoS ONE
Vol/bind	3
Udgave nummer	8
Sider (fra-til)	e2872
Antal sider	6
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0002872
Status	Udgivet - 2008

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Adgang til dokumentet

10.1371/journal.pone.0002872

Citationsformater

Sandholt, C. H., Mogensen, M. S., Borch-Johnsen, K., Sandbaek, A., Lauritzen, T., Sørensen, T. I. A., Hansen, L., Almind, K., Jørgensen, T., Pedersen, O., & Hansen, T. (2008). Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes. PLoS ONE, 3(8), e2872. https://doi.org/10.1371/journal.pone.0002872

Sandholt, CH, Mogensen, MS, Borch-Johnsen, K, Sandbaek, A, Lauritzen, T, Sørensen, TIA, Hansen, L, Almind, K, Jørgensen, T, Pedersen, O & Hansen, T 2008, 'Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes', PLoS ONE, bind 3, nr. 8, s. e2872. https://doi.org/10.1371/journal.pone.0002872

@article{946dd5a004a311deb05e000ea68e967b,

title = "Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes",

abstract = "The INSIG2 rs7566605 and PFKP rs6602024 polymorphisms have been identified as obesity gene variants in genome-wide association (GWA) studies. However, replication has been contradictory for both variants. The aims of this study were to validate these obesity-associations through case-control studies and analyses of obesity-related quantitative traits. Moreover, since environmental and genetic factors may modulate the impact of a genetic variant, we wanted to perform such interaction analyses. We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (rs9939609) and near MC4R (rs17782313) as genetic risk factors.",

keywords = "Blood Platelets, DNA Replication, Denmark, Exercise, Female, Genetic Variation, Genome, Human, Genotype, Humans, Intracellular Signaling Peptides and Proteins, Male, Membrane Proteins, Motor Activity, Obesity, Overweight, Phosphofructokinases, Polymorphism, Genetic",

author = "Sandholt, {Camilla Helene} and Mogensen, {Mette S} and Knut Borch-Johnsen and Annelli Sandbaek and Torsten Lauritzen and S{\o}rensen, {Thorkild I A} and Lars Hansen and Katrine Almind and Torben J{\o}rgensen and Oluf Pedersen and Torben Hansen",

year = "2008",

doi = "10.1371/journal.pone.0002872",

language = "English",

volume = "3",

pages = "e2872",

journal = "PLoS Computational Biology",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "8",

}

TY - JOUR

T1 - Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes

AU - Sandholt, Camilla Helene

AU - Mogensen, Mette S

AU - Borch-Johnsen, Knut

AU - Sandbaek, Annelli

AU - Lauritzen, Torsten

AU - Sørensen, Thorkild I A

AU - Hansen, Lars

AU - Almind, Katrine

AU - Jørgensen, Torben

AU - Pedersen, Oluf

AU - Hansen, Torben

PY - 2008

Y1 - 2008

N2 - The INSIG2 rs7566605 and PFKP rs6602024 polymorphisms have been identified as obesity gene variants in genome-wide association (GWA) studies. However, replication has been contradictory for both variants. The aims of this study were to validate these obesity-associations through case-control studies and analyses of obesity-related quantitative traits. Moreover, since environmental and genetic factors may modulate the impact of a genetic variant, we wanted to perform such interaction analyses. We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (rs9939609) and near MC4R (rs17782313) as genetic risk factors.

AB - The INSIG2 rs7566605 and PFKP rs6602024 polymorphisms have been identified as obesity gene variants in genome-wide association (GWA) studies. However, replication has been contradictory for both variants. The aims of this study were to validate these obesity-associations through case-control studies and analyses of obesity-related quantitative traits. Moreover, since environmental and genetic factors may modulate the impact of a genetic variant, we wanted to perform such interaction analyses. We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (rs9939609) and near MC4R (rs17782313) as genetic risk factors.

KW - Blood Platelets

KW - DNA Replication

KW - Denmark

KW - Exercise

KW - Female

KW - Genetic Variation

KW - Genome, Human

KW - Genotype

KW - Humans

KW - Intracellular Signaling Peptides and Proteins

KW - Male

KW - Membrane Proteins

KW - Motor Activity

KW - Obesity

KW - Overweight

KW - Phosphofructokinases

KW - Polymorphism, Genetic

U2 - 10.1371/journal.pone.0002872

DO - 10.1371/journal.pone.0002872

M3 - Journal article

C2 - 18682847

SN - 1932-6203

VL - 3

SP - e2872

JO - PLoS Computational Biology

JF - PLoS Computational Biology

IS - 8

ER -

Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes

Abstract

FN’s Verdensmål

Adgang til dokumentet

Fingeraftryk

Citationsformater