No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment

Jens Drachmann Bukh; Camilla Bock; Maj Vinberg; Thomas Werge; Ulrik Gether; Lars Vedel Kessing; Jens Drachmann Bukh; Camilla Bock; Maj Vinberg; Thomas Werge; Ulrik Gether; Lars Vedel Kessing

doi:10.1016/j.euroneuro.2009.11.004

No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment

Jens Drachmann Bukh, Camilla Bock, Maj Vinberg, Thomas Werge, Ulrik Gether, Lars Vedel Kessing, Jens Drachmann Bukh, Camilla Bock, Maj Vinberg, Thomas Werge, Ulrik Gether, Lars Vedel Kessing

31 Citations (Scopus)

Abstract

Genetic polymorphisms seem to influence the response on antidepressant treatment and moderate the impact of stress on depression. The present study aimed to assess, whether allelic variants and stressful life events interact on the clinical outcome of depression. In a sample of 290 systematically recruited patients diagnosed with a single depressive episode according to ICD-10, we assessed the outcome of antidepressant treatment and the presence of stressful life events in a 6-month period preceding onset of depression by means of structured interviews. Further, we genotyped nine polymorphisms in the genes encoding the serotonin transporter, brain derived neurotrophic factor, catechol-O-methyltransferase, angiotensin converting enzyme, tryptophan hydroxylase, and the serotonin receptors 1A, 2A, and 2C. We found no evidence that the effects of the genetic polymorphisms on treatment outcome were dependent on stressful life events experienced by the individual prior to onset of depression.

Original language	English
Journal	European Neuropsychopharmacology
ISSN	0924-977X
DOIs	https://doi.org/10.1016/j.euroneuro.2009.11.004 https://doi.org/10.1016/j.euroneuro.2009.11.004
Publication status	Published - 2009

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Bukh, J. D., Bock, C., Vinberg, M., Werge, T., Gether, U., Kessing, L. V., Bukh, J. D., Bock, C., Vinberg, M., Werge, T., Gether, U., & Kessing, L. V. (2009). No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment. European Neuropsychopharmacology. https://doi.org/10.1016/j.euroneuro.2009.11.004, https://doi.org/10.1016/j.euroneuro.2009.11.004

Bukh, JD, Bock, C, Vinberg, M , Werge, T , Gether, U , Kessing, LV, Bukh, JD, Bock, C, Vinberg, M , Werge, T, Gether, U & Kessing, LV 2009, 'No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment', European Neuropsychopharmacology. https://doi.org/10.1016/j.euroneuro.2009.11.004, https://doi.org/10.1016/j.euroneuro.2009.11.004

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title = "No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment",

abstract = "Genetic polymorphisms seem to influence the response on antidepressant treatment and moderate the impact of stress on depression. The present study aimed to assess, whether allelic variants and stressful life events interact on the clinical outcome of depression. In a sample of 290 systematically recruited patients diagnosed with a single depressive episode according to ICD-10, we assessed the outcome of antidepressant treatment and the presence of stressful life events in a 6-month period preceding onset of depression by means of structured interviews. Further, we genotyped nine polymorphisms in the genes encoding the serotonin transporter, brain derived neurotrophic factor, catechol-O-methyltransferase, angiotensin converting enzyme, tryptophan hydroxylase, and the serotonin receptors 1A, 2A, and 2C. We found no evidence that the effects of the genetic polymorphisms on treatment outcome were dependent on stressful life events experienced by the individual prior to onset of depression.",

author = "Bukh, {Jens Drachmann} and Camilla Bock and Maj Vinberg and Thomas Werge and Ulrik Gether and Kessing, {Lars Vedel} and Bukh, {Jens Drachmann} and Camilla Bock and Maj Vinberg and Thomas Werge and Ulrik Gether and Kessing, {Lars Vedel}",

note = "Keywords: Adult; Alleles; Antidepressive Agents; Depressive Disorder; Female; Genetic Predisposition to Disease; Genotype; Humans; Life Change Events; Male; Middle Aged; Polymorphism, Genetic; Questionnaires; Severity of Illness Index; Stress, Psychological; Treatment Outcome",

year = "2009",

doi = "10.1016/j.euroneuro.2009.11.004",

language = "English",

journal = "European Neuropsychopharmacology",

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T1 - No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment

AU - Bukh, Jens Drachmann

AU - Bock, Camilla

AU - Vinberg, Maj

AU - Werge, Thomas

AU - Gether, Ulrik

AU - Kessing, Lars Vedel

AU - Bukh, Jens Drachmann

AU - Bock, Camilla

AU - Vinberg, Maj

AU - Werge, Thomas

AU - Gether, Ulrik

AU - Kessing, Lars Vedel

N1 - Keywords: Adult; Alleles; Antidepressive Agents; Depressive Disorder; Female; Genetic Predisposition to Disease; Genotype; Humans; Life Change Events; Male; Middle Aged; Polymorphism, Genetic; Questionnaires; Severity of Illness Index; Stress, Psychological; Treatment Outcome

PY - 2009

Y1 - 2009

N2 - Genetic polymorphisms seem to influence the response on antidepressant treatment and moderate the impact of stress on depression. The present study aimed to assess, whether allelic variants and stressful life events interact on the clinical outcome of depression. In a sample of 290 systematically recruited patients diagnosed with a single depressive episode according to ICD-10, we assessed the outcome of antidepressant treatment and the presence of stressful life events in a 6-month period preceding onset of depression by means of structured interviews. Further, we genotyped nine polymorphisms in the genes encoding the serotonin transporter, brain derived neurotrophic factor, catechol-O-methyltransferase, angiotensin converting enzyme, tryptophan hydroxylase, and the serotonin receptors 1A, 2A, and 2C. We found no evidence that the effects of the genetic polymorphisms on treatment outcome were dependent on stressful life events experienced by the individual prior to onset of depression.

AB - Genetic polymorphisms seem to influence the response on antidepressant treatment and moderate the impact of stress on depression. The present study aimed to assess, whether allelic variants and stressful life events interact on the clinical outcome of depression. In a sample of 290 systematically recruited patients diagnosed with a single depressive episode according to ICD-10, we assessed the outcome of antidepressant treatment and the presence of stressful life events in a 6-month period preceding onset of depression by means of structured interviews. Further, we genotyped nine polymorphisms in the genes encoding the serotonin transporter, brain derived neurotrophic factor, catechol-O-methyltransferase, angiotensin converting enzyme, tryptophan hydroxylase, and the serotonin receptors 1A, 2A, and 2C. We found no evidence that the effects of the genetic polymorphisms on treatment outcome were dependent on stressful life events experienced by the individual prior to onset of depression.

U2 - 10.1016/j.euroneuro.2009.11.004

DO - 10.1016/j.euroneuro.2009.11.004

M3 - Journal article

C2 - 20022223

SN - 0924-977X

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

ER -

No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment

Abstract

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