No evidence for altered cellular immune functions in personnel deployed in the Persian Gulf during and after the Gulf War--The Danish Gulf War study

S Bregenholt; T Ishøy; L T Skovgaard; P Suadicani; M Appleyard; B Guldager; L Malte; F Gyntelberg; Mogens Helweg Claesson

No evidence for altered cellular immune functions in personnel deployed in the Persian Gulf during and after the Gulf War--The Danish Gulf War study

S Bregenholt, T Ishøy, L T Skovgaard, P Suadicani, M Appleyard, B Guldager, L Malte, F Gyntelberg, Mogens Helweg Claesson

10 Citations (Scopus)

Abstract

Veterans who have participated in the Gulf War suffer from a number of symptoms, collectively referred to as the Gulf War Syndrome. It has been hypothesized that a change in the systemic cytokine balance or other changes in immunological parameters could be responsible for some of the symptoms. We analyzed the peripheral blood natural killer (NK) cell activity of 686 Gulf War personnel who had been present in the Persian Gulf area during and immediately after the Gulf War as well as 231 gender and age-matched controls. The test material included individual samples of frozen peripheral blood mononuclear cells kept at -139 degrees C for a period of 50 to 380 days prior to NK cell analysis of freshly thawed cells. Significant differences in NK-cell activity were not observed by direct comparison of the levels of natural cytotoxic activity in the two groups. However, NK-cell cytotoxicity as such decreased due to cryopreservation. Surprisingly, the NK cells obtained from control donors were significantly (p

Original language	English
Journal	Acta Pathologica Microbiologica et Immunologica Scandinavica
Volume	109
Issue number	7-8
Pages (from-to)	517-24
Number of pages	8
ISSN	0903-4641
Publication status	Published - 2001

Keywords

Adult
Cross-Sectional Studies
Cytokines
Cytotoxicity, Immunologic
Female
Humans
Killer Cells, Natural
Male
Middle Aged
Persian Gulf Syndrome

Cite this

Bregenholt, S., Ishøy, T., Skovgaard, L. T., Suadicani, P., Appleyard, M., Guldager, B., Malte, L., Gyntelberg, F., & Claesson, M. H. (2001). No evidence for altered cellular immune functions in personnel deployed in the Persian Gulf during and after the Gulf War--The Danish Gulf War study. Acta Pathologica Microbiologica et Immunologica Scandinavica, 109(7-8), 517-24.

No evidence for altered cellular immune functions in personnel deployed in the Persian Gulf during and after the Gulf War--The Danish Gulf War study. / Bregenholt, S; Ishøy, T; Skovgaard, L T et al.

In: Acta Pathologica Microbiologica et Immunologica Scandinavica, Vol. 109, No. 7-8, 2001, p. 517-24.

Research output: Contribution to journal › Journal article › Research › peer-review

Bregenholt, S, Ishøy, T, Skovgaard, LT, Suadicani, P, Appleyard, M, Guldager, B, Malte, L, Gyntelberg, F & Claesson, MH 2001, 'No evidence for altered cellular immune functions in personnel deployed in the Persian Gulf during and after the Gulf War--The Danish Gulf War study', Acta Pathologica Microbiologica et Immunologica Scandinavica, vol. 109, no. 7-8, pp. 517-24.

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abstract = "Veterans who have participated in the Gulf War suffer from a number of symptoms, collectively referred to as the Gulf War Syndrome. It has been hypothesized that a change in the systemic cytokine balance or other changes in immunological parameters could be responsible for some of the symptoms. We analyzed the peripheral blood natural killer (NK) cell activity of 686 Gulf War personnel who had been present in the Persian Gulf area during and immediately after the Gulf War as well as 231 gender and age-matched controls. The test material included individual samples of frozen peripheral blood mononuclear cells kept at -139 degrees C for a period of 50 to 380 days prior to NK cell analysis of freshly thawed cells. Significant differences in NK-cell activity were not observed by direct comparison of the levels of natural cytotoxic activity in the two groups. However, NK-cell cytotoxicity as such decreased due to cryopreservation. Surprisingly, the NK cells obtained from control donors were significantly (p",

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AU - Bregenholt, S

AU - Ishøy, T

AU - Skovgaard, L T

AU - Suadicani, P

AU - Appleyard, M

AU - Guldager, B

AU - Malte, L

AU - Gyntelberg, F

AU - Claesson, Mogens Helweg

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AB - Veterans who have participated in the Gulf War suffer from a number of symptoms, collectively referred to as the Gulf War Syndrome. It has been hypothesized that a change in the systemic cytokine balance or other changes in immunological parameters could be responsible for some of the symptoms. We analyzed the peripheral blood natural killer (NK) cell activity of 686 Gulf War personnel who had been present in the Persian Gulf area during and immediately after the Gulf War as well as 231 gender and age-matched controls. The test material included individual samples of frozen peripheral blood mononuclear cells kept at -139 degrees C for a period of 50 to 380 days prior to NK cell analysis of freshly thawed cells. Significant differences in NK-cell activity were not observed by direct comparison of the levels of natural cytotoxic activity in the two groups. However, NK-cell cytotoxicity as such decreased due to cryopreservation. Surprisingly, the NK cells obtained from control donors were significantly (p

KW - Adult

KW - Cross-Sectional Studies

KW - Cytokines

KW - Cytotoxicity, Immunologic

KW - Female

KW - Humans

KW - Killer Cells, Natural

KW - Male

KW - Middle Aged

KW - Persian Gulf Syndrome

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SN - 0903-465X

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JO - APMIS. Supplementum

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No evidence for altered cellular immune functions in personnel deployed in the Persian Gulf during and after the Gulf War--The Danish Gulf War study

Abstract

Keywords

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