No evidence for altered cellular immune functions in personnel deployed in the Persian Gulf during and after the Gulf War--The Danish Gulf War study

TY - JOUR

T1 - No evidence for altered cellular immune functions in personnel deployed in the Persian Gulf during and after the Gulf War--The Danish Gulf War study

AU - Bregenholt, S

AU - Ishøy, T

AU - Skovgaard, L T

AU - Suadicani, P

AU - Appleyard, M

AU - Guldager, B

AU - Malte, L

AU - Gyntelberg, F

AU - Claesson, Mogens Helweg

PY - 2001

Y1 - 2001

N2 - Veterans who have participated in the Gulf War suffer from a number of symptoms, collectively referred to as the Gulf War Syndrome. It has been hypothesized that a change in the systemic cytokine balance or other changes in immunological parameters could be responsible for some of the symptoms. We analyzed the peripheral blood natural killer (NK) cell activity of 686 Gulf War personnel who had been present in the Persian Gulf area during and immediately after the Gulf War as well as 231 gender and age-matched controls. The test material included individual samples of frozen peripheral blood mononuclear cells kept at -139 degrees C for a period of 50 to 380 days prior to NK cell analysis of freshly thawed cells. Significant differences in NK-cell activity were not observed by direct comparison of the levels of natural cytotoxic activity in the two groups. However, NK-cell cytotoxicity as such decreased due to cryopreservation. Surprisingly, the NK cells obtained from control donors were significantly (p

AB - Veterans who have participated in the Gulf War suffer from a number of symptoms, collectively referred to as the Gulf War Syndrome. It has been hypothesized that a change in the systemic cytokine balance or other changes in immunological parameters could be responsible for some of the symptoms. We analyzed the peripheral blood natural killer (NK) cell activity of 686 Gulf War personnel who had been present in the Persian Gulf area during and immediately after the Gulf War as well as 231 gender and age-matched controls. The test material included individual samples of frozen peripheral blood mononuclear cells kept at -139 degrees C for a period of 50 to 380 days prior to NK cell analysis of freshly thawed cells. Significant differences in NK-cell activity were not observed by direct comparison of the levels of natural cytotoxic activity in the two groups. However, NK-cell cytotoxicity as such decreased due to cryopreservation. Surprisingly, the NK cells obtained from control donors were significantly (p

KW - Adult

KW - Cross-Sectional Studies

KW - Cytokines

KW - Cytotoxicity, Immunologic

KW - Female

KW - Humans

KW - Killer Cells, Natural

KW - Male

KW - Middle Aged

KW - Persian Gulf Syndrome

M3 - Journal article

C2 - 11552949

SN - 0903-465X

VL - 109

SP - 517

EP - 524

JO - APMIS. Supplementum

JF - APMIS. Supplementum

IS - 7-8

ER -