No association between type 1 diabetes and genetic variation in vitamin D metabolism genes: a Danish study

Steffen U Thorsen; Henrik B Mortensen; Bendix Carstensen; Mogens Fenger; Betina H Thuesen; Lotte Husemoen; Regine Bergholdt; Caroline Brorsson; Flemming Pociot; Allan Linneberg; Jannet Svensson

doi:10.1111/pedi.12105

No association between type 1 diabetes and genetic variation in vitamin D metabolism genes: a Danish study

Steffen U Thorsen, Henrik B Mortensen, Bendix Carstensen, Mogens Fenger, Betina H Thuesen, Lotte Husemoen, Regine Bergholdt, Caroline Brorsson, Flemming Pociot, Allan Linneberg, Jannet Svensson

19 Citations (Scopus)

Abstract

BACKGROUND: Vitamin D, certain single nucleotide polymorphisms (SNPs) in the vitamin D-receptor (VDR) gene and vitamin D metabolism genes have been associated with type 1 diabetes (T1D).

OBJECTIVE: We wanted to examine if the most widely studied SNPs in genes important for production, transport, and action of vitamin D were associated with T1D or to circulating levels of vitamin D 25-hydroxyvitamin D [25(OH)D] in a juvenile Danish population.

METHODS: We genotyped eight SNPs in five vitamin D metabolism genes in 1467 trios. 25(OH)D status were analyzed in 1803 children (907 patients and 896 siblings).

RESULTS: We did not demonstrate association with T1D for SNPs in the following genes: CYP27B1, VDR, GC, CYP2R1, DHCR7, and CYP24A1. Though, variants in the GC gene were significantly associated with 25(OH)D levels in the joint model.

CONCLUSION: Some of the most examined SNPs in vitamin D metabolism genes were not confirmed to be associated with T1D, though 25(OH) levels were associated with variants in the GC gene.

Original language	English
Journal	Pediatric Diabetes
Volume	15
Issue number	6
Pages (from-to)	416-421
Number of pages	6
ISSN	1399-543X
DOIs	https://doi.org/10.1111/pedi.12105
Publication status	Published - Sept 2014

Keywords

25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Adolescent
Child
Child, Preschool
Cholestanetriol 26-Monooxygenase
Denmark
Diabetes Mellitus, Type 1
Female
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Infant
Infant, Newborn
Male
Metabolic Networks and Pathways
Oxidoreductases Acting on CH-CH Group Donors
Polymorphism, Single Nucleotide
Receptors, Calcitriol
Vitamin D
Vitamin D-Binding Protein
Vitamin D3 24-Hydroxylase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/pedi.12105

Cite this

@article{75e4ffbee6064a549bcdd4552e53d2bd,

title = "No association between type 1 diabetes and genetic variation in vitamin D metabolism genes: a Danish study",

abstract = "BACKGROUND: Vitamin D, certain single nucleotide polymorphisms (SNPs) in the vitamin D-receptor (VDR) gene and vitamin D metabolism genes have been associated with type 1 diabetes (T1D).OBJECTIVE: We wanted to examine if the most widely studied SNPs in genes important for production, transport, and action of vitamin D were associated with T1D or to circulating levels of vitamin D 25-hydroxyvitamin D [25(OH)D] in a juvenile Danish population.METHODS: We genotyped eight SNPs in five vitamin D metabolism genes in 1467 trios. 25(OH)D status were analyzed in 1803 children (907 patients and 896 siblings).RESULTS: We did not demonstrate association with T1D for SNPs in the following genes: CYP27B1, VDR, GC, CYP2R1, DHCR7, and CYP24A1. Though, variants in the GC gene were significantly associated with 25(OH)D levels in the joint model.CONCLUSION: Some of the most examined SNPs in vitamin D metabolism genes were not confirmed to be associated with T1D, though 25(OH) levels were associated with variants in the GC gene.",

keywords = "25-Hydroxyvitamin D3 1-alpha-Hydroxylase, Adolescent, Child, Child, Preschool, Cholestanetriol 26-Monooxygenase, Denmark, Diabetes Mellitus, Type 1, Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Infant, Infant, Newborn, Male, Metabolic Networks and Pathways, Oxidoreductases Acting on CH-CH Group Donors, Polymorphism, Single Nucleotide, Receptors, Calcitriol, Vitamin D, Vitamin D-Binding Protein, Vitamin D3 24-Hydroxylase",

author = "Thorsen, {Steffen U} and Mortensen, {Henrik B} and Bendix Carstensen and Mogens Fenger and Thuesen, {Betina H} and Lotte Husemoen and Regine Bergholdt and Caroline Brorsson and Flemming Pociot and Allan Linneberg and Jannet Svensson",

note = "{\textcopyright} 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

year = "2014",

month = sep,

doi = "10.1111/pedi.12105",

language = "English",

volume = "15",

pages = "416--421",

journal = "Pediatric Diabetes",

issn = "1399-543X",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - No association between type 1 diabetes and genetic variation in vitamin D metabolism genes

T2 - a Danish study

AU - Thorsen, Steffen U

AU - Mortensen, Henrik B

AU - Carstensen, Bendix

AU - Fenger, Mogens

AU - Thuesen, Betina H

AU - Husemoen, Lotte

AU - Bergholdt, Regine

AU - Brorsson, Caroline

AU - Pociot, Flemming

AU - Linneberg, Allan

AU - Svensson, Jannet

PY - 2014/9

Y1 - 2014/9

N2 - BACKGROUND: Vitamin D, certain single nucleotide polymorphisms (SNPs) in the vitamin D-receptor (VDR) gene and vitamin D metabolism genes have been associated with type 1 diabetes (T1D).OBJECTIVE: We wanted to examine if the most widely studied SNPs in genes important for production, transport, and action of vitamin D were associated with T1D or to circulating levels of vitamin D 25-hydroxyvitamin D [25(OH)D] in a juvenile Danish population.METHODS: We genotyped eight SNPs in five vitamin D metabolism genes in 1467 trios. 25(OH)D status were analyzed in 1803 children (907 patients and 896 siblings).RESULTS: We did not demonstrate association with T1D for SNPs in the following genes: CYP27B1, VDR, GC, CYP2R1, DHCR7, and CYP24A1. Though, variants in the GC gene were significantly associated with 25(OH)D levels in the joint model.CONCLUSION: Some of the most examined SNPs in vitamin D metabolism genes were not confirmed to be associated with T1D, though 25(OH) levels were associated with variants in the GC gene.

AB - BACKGROUND: Vitamin D, certain single nucleotide polymorphisms (SNPs) in the vitamin D-receptor (VDR) gene and vitamin D metabolism genes have been associated with type 1 diabetes (T1D).OBJECTIVE: We wanted to examine if the most widely studied SNPs in genes important for production, transport, and action of vitamin D were associated with T1D or to circulating levels of vitamin D 25-hydroxyvitamin D [25(OH)D] in a juvenile Danish population.METHODS: We genotyped eight SNPs in five vitamin D metabolism genes in 1467 trios. 25(OH)D status were analyzed in 1803 children (907 patients and 896 siblings).RESULTS: We did not demonstrate association with T1D for SNPs in the following genes: CYP27B1, VDR, GC, CYP2R1, DHCR7, and CYP24A1. Though, variants in the GC gene were significantly associated with 25(OH)D levels in the joint model.CONCLUSION: Some of the most examined SNPs in vitamin D metabolism genes were not confirmed to be associated with T1D, though 25(OH) levels were associated with variants in the GC gene.

KW - 25-Hydroxyvitamin D3 1-alpha-Hydroxylase

KW - Adolescent

KW - Child

KW - Child, Preschool

KW - Cholestanetriol 26-Monooxygenase

KW - Denmark

KW - Diabetes Mellitus, Type 1

KW - Female

KW - Genetic Association Studies

KW - Genetic Predisposition to Disease

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Metabolic Networks and Pathways

KW - Oxidoreductases Acting on CH-CH Group Donors

KW - Polymorphism, Single Nucleotide

KW - Receptors, Calcitriol

KW - Vitamin D

KW - Vitamin D-Binding Protein

KW - Vitamin D3 24-Hydroxylase

U2 - 10.1111/pedi.12105

DO - 10.1111/pedi.12105

M3 - Journal article

C2 - 24325596

SN - 1399-543X

VL - 15

SP - 416

EP - 421

JO - Pediatric Diabetes

JF - Pediatric Diabetes

IS - 6

ER -

No association between type 1 diabetes and genetic variation in vitamin D metabolism genes: a Danish study

Abstract

Keywords

UN SDGs

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