Abstract
BACKGROUND: Vitamin D, certain single nucleotide polymorphisms (SNPs) in the vitamin D-receptor (VDR) gene and vitamin D metabolism genes have been associated with type 1 diabetes (T1D).
OBJECTIVE: We wanted to examine if the most widely studied SNPs in genes important for production, transport, and action of vitamin D were associated with T1D or to circulating levels of vitamin D 25-hydroxyvitamin D [25(OH)D] in a juvenile Danish population.
METHODS: We genotyped eight SNPs in five vitamin D metabolism genes in 1467 trios. 25(OH)D status were analyzed in 1803 children (907 patients and 896 siblings).
RESULTS: We did not demonstrate association with T1D for SNPs in the following genes: CYP27B1, VDR, GC, CYP2R1, DHCR7, and CYP24A1. Though, variants in the GC gene were significantly associated with 25(OH)D levels in the joint model.
CONCLUSION: Some of the most examined SNPs in vitamin D metabolism genes were not confirmed to be associated with T1D, though 25(OH) levels were associated with variants in the GC gene.
| Original language | English |
|---|---|
| Journal | Pediatric Diabetes |
| Volume | 15 |
| Issue number | 6 |
| Pages (from-to) | 416-421 |
| Number of pages | 6 |
| ISSN | 1399-543X |
| DOIs | |
| Publication status | Published - Sept 2014 |
Keywords
- 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
- Adolescent
- Child
- Child, Preschool
- Cholestanetriol 26-Monooxygenase
- Denmark
- Diabetes Mellitus, Type 1
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Infant
- Infant, Newborn
- Male
- Metabolic Networks and Pathways
- Oxidoreductases Acting on CH-CH Group Donors
- Polymorphism, Single Nucleotide
- Receptors, Calcitriol
- Vitamin D
- Vitamin D-Binding Protein
- Vitamin D3 24-Hydroxylase
