No association between type 1 diabetes and genetic variation in vitamin D metabolism genes: a Danish study

Steffen U Thorsen; Henrik B Mortensen; Bendix Carstensen; Mogens Fenger; Betina H Thuesen; Lotte Husemoen; Regine Bergholdt; Caroline Brorsson; Flemming Pociot; Allan Linneberg; Jannet Svensson

doi:10.1111/pedi.12105

No association between type 1 diabetes and genetic variation in vitamin D metabolism genes: a Danish study

Steffen U Thorsen, Henrik B Mortensen, Bendix Carstensen, Mogens Fenger, Betina H Thuesen, Lotte Husemoen, Regine Bergholdt, Caroline Brorsson, Flemming Pociot, Allan Linneberg, Jannet Svensson

19 Citationer (Scopus)

Abstract

BACKGROUND: Vitamin D, certain single nucleotide polymorphisms (SNPs) in the vitamin D-receptor (VDR) gene and vitamin D metabolism genes have been associated with type 1 diabetes (T1D).

OBJECTIVE: We wanted to examine if the most widely studied SNPs in genes important for production, transport, and action of vitamin D were associated with T1D or to circulating levels of vitamin D 25-hydroxyvitamin D [25(OH)D] in a juvenile Danish population.

METHODS: We genotyped eight SNPs in five vitamin D metabolism genes in 1467 trios. 25(OH)D status were analyzed in 1803 children (907 patients and 896 siblings).

RESULTS: We did not demonstrate association with T1D for SNPs in the following genes: CYP27B1, VDR, GC, CYP2R1, DHCR7, and CYP24A1. Though, variants in the GC gene were significantly associated with 25(OH)D levels in the joint model.

CONCLUSION: Some of the most examined SNPs in vitamin D metabolism genes were not confirmed to be associated with T1D, though 25(OH) levels were associated with variants in the GC gene.

Originalsprog	Engelsk
Tidsskrift	Pediatric Diabetes
Vol/bind	15
Udgave nummer	6
Sider (fra-til)	416-421
Antal sider	6
ISSN	1399-543X
DOI	https://doi.org/10.1111/pedi.12105
Status	Udgivet - sep. 2014

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Adgang til dokumentet

10.1111/pedi.12105

Citationsformater

@article{75e4ffbee6064a549bcdd4552e53d2bd,

title = "No association between type 1 diabetes and genetic variation in vitamin D metabolism genes: a Danish study",

abstract = "BACKGROUND: Vitamin D, certain single nucleotide polymorphisms (SNPs) in the vitamin D-receptor (VDR) gene and vitamin D metabolism genes have been associated with type 1 diabetes (T1D).OBJECTIVE: We wanted to examine if the most widely studied SNPs in genes important for production, transport, and action of vitamin D were associated with T1D or to circulating levels of vitamin D 25-hydroxyvitamin D [25(OH)D] in a juvenile Danish population.METHODS: We genotyped eight SNPs in five vitamin D metabolism genes in 1467 trios. 25(OH)D status were analyzed in 1803 children (907 patients and 896 siblings).RESULTS: We did not demonstrate association with T1D for SNPs in the following genes: CYP27B1, VDR, GC, CYP2R1, DHCR7, and CYP24A1. Though, variants in the GC gene were significantly associated with 25(OH)D levels in the joint model.CONCLUSION: Some of the most examined SNPs in vitamin D metabolism genes were not confirmed to be associated with T1D, though 25(OH) levels were associated with variants in the GC gene.",

keywords = "25-Hydroxyvitamin D3 1-alpha-Hydroxylase, Adolescent, Child, Child, Preschool, Cholestanetriol 26-Monooxygenase, Denmark, Diabetes Mellitus, Type 1, Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Infant, Infant, Newborn, Male, Metabolic Networks and Pathways, Oxidoreductases Acting on CH-CH Group Donors, Polymorphism, Single Nucleotide, Receptors, Calcitriol, Vitamin D, Vitamin D-Binding Protein, Vitamin D3 24-Hydroxylase",

author = "Thorsen, {Steffen U} and Mortensen, {Henrik B} and Bendix Carstensen and Mogens Fenger and Thuesen, {Betina H} and Lotte Husemoen and Regine Bergholdt and Caroline Brorsson and Flemming Pociot and Allan Linneberg and Jannet Svensson",

note = "{\textcopyright} 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

year = "2014",

month = sep,

doi = "10.1111/pedi.12105",

language = "English",

volume = "15",

pages = "416--421",

journal = "Pediatric Diabetes",

issn = "1399-543X",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - No association between type 1 diabetes and genetic variation in vitamin D metabolism genes

T2 - a Danish study

AU - Thorsen, Steffen U

AU - Mortensen, Henrik B

AU - Carstensen, Bendix

AU - Fenger, Mogens

AU - Thuesen, Betina H

AU - Husemoen, Lotte

AU - Bergholdt, Regine

AU - Brorsson, Caroline

AU - Pociot, Flemming

AU - Linneberg, Allan

AU - Svensson, Jannet

PY - 2014/9

Y1 - 2014/9

N2 - BACKGROUND: Vitamin D, certain single nucleotide polymorphisms (SNPs) in the vitamin D-receptor (VDR) gene and vitamin D metabolism genes have been associated with type 1 diabetes (T1D).OBJECTIVE: We wanted to examine if the most widely studied SNPs in genes important for production, transport, and action of vitamin D were associated with T1D or to circulating levels of vitamin D 25-hydroxyvitamin D [25(OH)D] in a juvenile Danish population.METHODS: We genotyped eight SNPs in five vitamin D metabolism genes in 1467 trios. 25(OH)D status were analyzed in 1803 children (907 patients and 896 siblings).RESULTS: We did not demonstrate association with T1D for SNPs in the following genes: CYP27B1, VDR, GC, CYP2R1, DHCR7, and CYP24A1. Though, variants in the GC gene were significantly associated with 25(OH)D levels in the joint model.CONCLUSION: Some of the most examined SNPs in vitamin D metabolism genes were not confirmed to be associated with T1D, though 25(OH) levels were associated with variants in the GC gene.

AB - BACKGROUND: Vitamin D, certain single nucleotide polymorphisms (SNPs) in the vitamin D-receptor (VDR) gene and vitamin D metabolism genes have been associated with type 1 diabetes (T1D).OBJECTIVE: We wanted to examine if the most widely studied SNPs in genes important for production, transport, and action of vitamin D were associated with T1D or to circulating levels of vitamin D 25-hydroxyvitamin D [25(OH)D] in a juvenile Danish population.METHODS: We genotyped eight SNPs in five vitamin D metabolism genes in 1467 trios. 25(OH)D status were analyzed in 1803 children (907 patients and 896 siblings).RESULTS: We did not demonstrate association with T1D for SNPs in the following genes: CYP27B1, VDR, GC, CYP2R1, DHCR7, and CYP24A1. Though, variants in the GC gene were significantly associated with 25(OH)D levels in the joint model.CONCLUSION: Some of the most examined SNPs in vitamin D metabolism genes were not confirmed to be associated with T1D, though 25(OH) levels were associated with variants in the GC gene.

KW - 25-Hydroxyvitamin D3 1-alpha-Hydroxylase

KW - Adolescent

KW - Child

KW - Child, Preschool

KW - Cholestanetriol 26-Monooxygenase

KW - Denmark

KW - Diabetes Mellitus, Type 1

KW - Female

KW - Genetic Association Studies

KW - Genetic Predisposition to Disease

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Metabolic Networks and Pathways

KW - Oxidoreductases Acting on CH-CH Group Donors

KW - Polymorphism, Single Nucleotide

KW - Receptors, Calcitriol

KW - Vitamin D

KW - Vitamin D-Binding Protein

KW - Vitamin D3 24-Hydroxylase

U2 - 10.1111/pedi.12105

DO - 10.1111/pedi.12105

M3 - Journal article

C2 - 24325596

SN - 1399-543X

VL - 15

SP - 416

EP - 421

JO - Pediatric Diabetes

JF - Pediatric Diabetes

IS - 6

ER -

No association between type 1 diabetes and genetic variation in vitamin D metabolism genes: a Danish study

Abstract

FN’s Verdensmål

Adgang til dokumentet

Fingeraftryk

Citationsformater