No association between DGKH and bipolar disorder in a Scandinavian case-control sample

Martin Tesli; Anna Kähler; Bettina Andreassen; Thomas Werge; Ole Mors; Erling Mellerup; Pernille Koefoed; Ingrid Melle; Gunnar Morken; Katrine Wirgenes; Ole Andreassen; Srdjan Djurovic; Martin Tesli; Anna K Kähler; Bettina Kulle Andreassen; Thomas Werge; Ole Mors; Erling Mellerup; Pernille Koefoed; Ingrid Melle; Gunnar Morken; Katrine V Wirgenes; Ole A Andreassen; Srdjan Djurovic

doi:10.1097/YPG.0b013e32832d302f

No association between DGKH and bipolar disorder in a Scandinavian case-control sample

Martin Tesli, Anna Kähler, Bettina Andreassen, Thomas Werge, Ole Mors, Erling Mellerup, Pernille Koefoed, Ingrid Melle, Gunnar Morken, Katrine Wirgenes, Ole Andreassen, Srdjan Djurovic, Martin Tesli, Anna K Kähler, Bettina Kulle Andreassen, Thomas Werge, Ole Mors, Erling Mellerup, Pernille Koefoed, Ingrid MelleGunnar Morken, Katrine V Wirgenes, Ole A Andreassen, Srdjan Djurovic

20 Citations (Scopus)

Abstract

Single nucleotide polymorphisms (SNPs) in diacylglycerol kinase eta (DGKH) have recently been shown to be associated with bipolar disorder (BD). To replicate this finding, we carried out a gene-wide genotyping of 36 tagSNPs in DGKH and performed a population-based association study on two Scandinavian samples, with successful genotyping of 594 BD cases and 1421 healthy controls. We found no significant association after multiple-testing correction between any of these SNPs and BD in our sample. Thus, it is unlikely that these genetic variations confer susceptibility to BD in this large Scandinavian sample.

Original language	English
Journal	Psychiatric Genetics
Volume	19
Issue number	5
Pages (from-to)	269-72
Number of pages	3
ISSN	0955-8829
DOIs	https://doi.org/10.1097/YPG.0b013e32832d302f https://doi.org/10.1097/YPG.0b013e32832d302f
Publication status	Published - 2009

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Tesli, M., Kähler, A., Andreassen, B., Werge, T., Mors, O., Mellerup, E., Koefoed, P., Melle, I., Morken, G., Wirgenes, K., Andreassen, O., Djurovic, S., Tesli, M., Kähler, A. K., Andreassen, B. K., Werge, T., Mors, O., Mellerup, E., Koefoed, P., ... Djurovic, S. (2009). No association between DGKH and bipolar disorder in a Scandinavian case-control sample. Psychiatric Genetics, 19(5), 269-72. https://doi.org/10.1097/YPG.0b013e32832d302f, https://doi.org/10.1097/YPG.0b013e32832d302f

Tesli, M, Kähler, A, Andreassen, B, Werge, T, Mors, O, Mellerup, E, Koefoed, P, Melle, I, Morken, G, Wirgenes, K, Andreassen, O, Djurovic, S, Tesli, M, Kähler, AK, Andreassen, BK, Werge, T, Mors, O, Mellerup, E, Koefoed, P, Melle, I, Morken, G, Wirgenes, KV, Andreassen, OA & Djurovic, S 2009, 'No association between DGKH and bipolar disorder in a Scandinavian case-control sample', Psychiatric Genetics, vol. 19, no. 5, pp. 269-72. https://doi.org/10.1097/YPG.0b013e32832d302f, https://doi.org/10.1097/YPG.0b013e32832d302f

@article{3c2f39308c0011de8bc9000ea68e967b,

title = "No association between DGKH and bipolar disorder in a Scandinavian case-control sample",

abstract = "Single nucleotide polymorphisms (SNPs) in diacylglycerol kinase eta (DGKH) have recently been shown to be associated with bipolar disorder (BD). To replicate this finding, we carried out a gene-wide genotyping of 36 tagSNPs in DGKH and performed a population-based association study on two Scandinavian samples, with successful genotyping of 594 BD cases and 1421 healthy controls. We found no significant association after multiple-testing correction between any of these SNPs and BD in our sample. Thus, it is unlikely that these genetic variations confer susceptibility to BD in this large Scandinavian sample.",

author = "Martin Tesli and Anna K{\"a}hler and Bettina Andreassen and Thomas Werge and Ole Mors and Erling Mellerup and Pernille Koefoed and Ingrid Melle and Gunnar Morken and Katrine Wirgenes and Ole Andreassen and Srdjan Djurovic and Martin Tesli and K{\"a}hler, {Anna K} and Andreassen, {Bettina Kulle} and Thomas Werge and Ole Mors and Erling Mellerup and Pernille Koefoed and Ingrid Melle and Gunnar Morken and Wirgenes, {Katrine V} and Andreassen, {Ole A} and Srdjan Djurovic",

note = "Keywords: Adult; Bipolar Disorder; Case-Control Studies; Diacylglycerol Kinase; European Continental Ancestry Group; Female; Genetic Markers; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Scandinavia",

year = "2009",

doi = "10.1097/YPG.0b013e32832d302f",

language = "English",

volume = "19",

pages = "269--72",

journal = "Psychiatric Genetics",

issn = "0955-8829",

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TY - JOUR

T1 - No association between DGKH and bipolar disorder in a Scandinavian case-control sample

AU - Tesli, Martin

AU - Kähler, Anna

AU - Andreassen, Bettina

AU - Werge, Thomas

AU - Mors, Ole

AU - Mellerup, Erling

AU - Koefoed, Pernille

AU - Melle, Ingrid

AU - Morken, Gunnar

AU - Wirgenes, Katrine

AU - Andreassen, Ole

AU - Djurovic, Srdjan

AU - Tesli, Martin

AU - Kähler, Anna K

AU - Andreassen, Bettina Kulle

AU - Werge, Thomas

AU - Mors, Ole

AU - Mellerup, Erling

AU - Koefoed, Pernille

AU - Melle, Ingrid

AU - Morken, Gunnar

AU - Wirgenes, Katrine V

AU - Andreassen, Ole A

AU - Djurovic, Srdjan

N1 - Keywords: Adult; Bipolar Disorder; Case-Control Studies; Diacylglycerol Kinase; European Continental Ancestry Group; Female; Genetic Markers; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Scandinavia

PY - 2009

Y1 - 2009

N2 - Single nucleotide polymorphisms (SNPs) in diacylglycerol kinase eta (DGKH) have recently been shown to be associated with bipolar disorder (BD). To replicate this finding, we carried out a gene-wide genotyping of 36 tagSNPs in DGKH and performed a population-based association study on two Scandinavian samples, with successful genotyping of 594 BD cases and 1421 healthy controls. We found no significant association after multiple-testing correction between any of these SNPs and BD in our sample. Thus, it is unlikely that these genetic variations confer susceptibility to BD in this large Scandinavian sample.

AB - Single nucleotide polymorphisms (SNPs) in diacylglycerol kinase eta (DGKH) have recently been shown to be associated with bipolar disorder (BD). To replicate this finding, we carried out a gene-wide genotyping of 36 tagSNPs in DGKH and performed a population-based association study on two Scandinavian samples, with successful genotyping of 594 BD cases and 1421 healthy controls. We found no significant association after multiple-testing correction between any of these SNPs and BD in our sample. Thus, it is unlikely that these genetic variations confer susceptibility to BD in this large Scandinavian sample.

U2 - 10.1097/YPG.0b013e32832d302f

DO - 10.1097/YPG.0b013e32832d302f

M3 - Journal article

C2 - 19478689

SN - 0955-8829

VL - 19

SP - 269

EP - 272

JO - Psychiatric Genetics

JF - Psychiatric Genetics

IS - 5

ER -

No association between DGKH and bipolar disorder in a Scandinavian case-control sample

Abstract

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