NMR-based metabolomics for identification of α-amylase inhibitors in rowan berries (Sorbus spp.)

Sofie L. Broholm; Simone Gramsbergen; Nils Nyberg; Anna Jäger; Dan Stærk

NMR-based metabolomics for identification of α-amylase inhibitors in rowan berries (Sorbus spp.)

Sofie L. Broholm, Simone Gramsbergen, Nils Nyberg, Anna Jäger, Dan Stærk

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Abstract

Type 2 diabetes is a metabolic disorder estimated to affect millions of people all over the world.1 One way of reducing diabetes-related complications is to control
postprandial glucose.2 Inhibition of the carbohydrate digestive enzyme α-amylase is a therapeutic target for maintaining low blood glucose levels. A study from 2011
shows that berries from Sorbus spp (rowan berries) effectively inhibit α-amylase activity and suggests that the active compounds are proanthocyanidins.3 The aim of this
project is to identify the rowan berry species with highest α-amylase inhibitory activity - and to find a 1H-NMR method suitable for NMR-based metabolomics

Original language	English
Publication date	2015
Number of pages	1
Publication status	Published - 2015
Event	36th Danish NMR Meeting - Lund, Sweden Duration: 19 Jan 2015 → 20 Jan 2015

Conference

Conference	36th Danish NMR Meeting
Country/Territory	Sweden
City	Lund
Period	19/01/2015 → 20/01/2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Danish NMR meeting 2015 SISOSubmitted manuscript, 15.6 MB

Cite this

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title = "NMR-based metabolomics for identification of α-amylase inhibitors in rowan berries (Sorbus spp.)",

abstract = "Type 2 diabetes is a metabolic disorder estimated to affect millions of people all over the world.1 One way of reducing diabetes-related complications is to controlpostprandial glucose.2 Inhibition of the carbohydrate digestive enzyme α-amylase is a therapeutic target for maintaining low blood glucose levels. A study from 2011shows that berries from Sorbus spp (rowan berries) effectively inhibit α-amylase activity and suggests that the active compounds are proanthocyanidins.3 The aim of thisproject is to identify the rowan berry species with highest α-amylase inhibitory activity - and to find a 1H-NMR method suitable for NMR-based metabolomics",

author = "Broholm, {Sofie L.} and Simone Gramsbergen and Nils Nyberg and Anna J{\"a}ger and Dan St{\ae}rk",

year = "2015",

language = "English",

note = "36th Danish NMR Meeting ; Conference date: 19-01-2015 Through 20-01-2015",

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TY - CONF

T1 - NMR-based metabolomics for identification of α-amylase inhibitors in rowan berries (Sorbus spp.)

AU - Broholm, Sofie L.

AU - Gramsbergen, Simone

AU - Nyberg, Nils

AU - Jäger, Anna

AU - Stærk, Dan

PY - 2015

Y1 - 2015

N2 - Type 2 diabetes is a metabolic disorder estimated to affect millions of people all over the world.1 One way of reducing diabetes-related complications is to controlpostprandial glucose.2 Inhibition of the carbohydrate digestive enzyme α-amylase is a therapeutic target for maintaining low blood glucose levels. A study from 2011shows that berries from Sorbus spp (rowan berries) effectively inhibit α-amylase activity and suggests that the active compounds are proanthocyanidins.3 The aim of thisproject is to identify the rowan berry species with highest α-amylase inhibitory activity - and to find a 1H-NMR method suitable for NMR-based metabolomics

AB - Type 2 diabetes is a metabolic disorder estimated to affect millions of people all over the world.1 One way of reducing diabetes-related complications is to controlpostprandial glucose.2 Inhibition of the carbohydrate digestive enzyme α-amylase is a therapeutic target for maintaining low blood glucose levels. A study from 2011shows that berries from Sorbus spp (rowan berries) effectively inhibit α-amylase activity and suggests that the active compounds are proanthocyanidins.3 The aim of thisproject is to identify the rowan berry species with highest α-amylase inhibitory activity - and to find a 1H-NMR method suitable for NMR-based metabolomics

M3 - Poster

T2 - 36th Danish NMR Meeting

Y2 - 19 January 2015 through 20 January 2015

ER -

NMR-based metabolomics for identification of α-amylase inhibitors in rowan berries (Sorbus spp.)

Abstract

Conference

UN SDGs

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