NMR-based metabolomics for identification of α-amylase inhibitors in rowan berries (Sorbus spp.)

TY - CONF

T1 - NMR-based metabolomics for identification of α-amylase inhibitors in rowan berries (Sorbus spp.)

AU - Broholm, Sofie L.

AU - Gramsbergen, Simone

AU - Nyberg, Nils

AU - Jäger, Anna

AU - Stærk, Dan

PY - 2015

Y1 - 2015

N2 - Type 2 diabetes is a metabolic disorder estimated to affect millions of people all over the world.1 One way of reducing diabetes-related complications is to controlpostprandial glucose.2 Inhibition of the carbohydrate digestive enzyme α-amylase is a therapeutic target for maintaining low blood glucose levels. A study from 2011shows that berries from Sorbus spp (rowan berries) effectively inhibit α-amylase activity and suggests that the active compounds are proanthocyanidins.3 The aim of thisproject is to identify the rowan berry species with highest α-amylase inhibitory activity - and to find a 1H-NMR method suitable for NMR-based metabolomics

AB - Type 2 diabetes is a metabolic disorder estimated to affect millions of people all over the world.1 One way of reducing diabetes-related complications is to controlpostprandial glucose.2 Inhibition of the carbohydrate digestive enzyme α-amylase is a therapeutic target for maintaining low blood glucose levels. A study from 2011shows that berries from Sorbus spp (rowan berries) effectively inhibit α-amylase activity and suggests that the active compounds are proanthocyanidins.3 The aim of thisproject is to identify the rowan berry species with highest α-amylase inhibitory activity - and to find a 1H-NMR method suitable for NMR-based metabolomics

M3 - Poster

T2 - 36th Danish NMR Meeting

Y2 - 19 January 2015 through 20 January 2015

ER -