Network medicine strikes a blow against breast cancer

Janine T Erler; Rune Linding

doi:10.1016/j.cell.2012.04.014

Network medicine strikes a blow against breast cancer

43 Citations (Scopus)

Abstract

Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.

Original language	English
Journal	Cell
Volume	149
Issue number	4
Pages (from-to)	731-3
Number of pages	3
ISSN	0092-8674
DOIs	https://doi.org/10.1016/j.cell.2012.04.014
Publication status	Published - 11 May 2012

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10.1016/j.cell.2012.04.014

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title = "Network medicine strikes a blow against breast cancer",

abstract = "Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.",

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AU - Linding, Rune

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AB - Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.

U2 - 10.1016/j.cell.2012.04.014

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JO - Cell

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Network medicine strikes a blow against breast cancer

Abstract

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