Network medicine strikes a blow against breast cancer

Janine T Erler; Rune Linding

doi:10.1016/j.cell.2012.04.014

Network medicine strikes a blow against breast cancer

43 Citationer (Scopus)

Abstract

Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.

Originalsprog	Engelsk
Tidsskrift	Cell
Vol/bind	149
Udgave nummer	4
Sider (fra-til)	731-3
Antal sider	3
ISSN	0092-8674
DOI	https://doi.org/10.1016/j.cell.2012.04.014
Status	Udgivet - 11 maj 2012

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10.1016/j.cell.2012.04.014

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title = "Network medicine strikes a blow against breast cancer",

abstract = "Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.",

author = "Erler, {Janine T} and Rune Linding",

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AU - Erler, Janine T

AU - Linding, Rune

PY - 2012/5/11

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N2 - Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.

AB - Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.

U2 - 10.1016/j.cell.2012.04.014

DO - 10.1016/j.cell.2012.04.014

M3 - Review

C2 - 22579276

SN - 0092-8674

VL - 149

SP - 731

EP - 733

JO - Cell

JF - Cell

IS - 4

ER -

Network medicine strikes a blow against breast cancer

Abstract

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