Nanomaterials vs Ambient Ultrafine Particles: an Opportunity to Exchange Toxicology Knowledge

Vicki Stone; Mark R. Miller; Martin J. D. Clift; Alison Elder; Nicholas L. Mills; Peter Møller; Roel P. F. Schins; Ulla Vogel; Wolfgang G. Kreyling; Keld Alstrup Jensen; Thomas A. J. Kuhlbusch; Per E. Schwarze; Peter Hoet; Antonio Pietroiusti; Andrea De Vizcaya-Ruiz; Armelle Baeza-Squiban; C. Lang Tran; Flemming R. Cassee

doi:10.1289/EHP424

Nanomaterials vs Ambient Ultrafine Particles: an Opportunity to Exchange Toxicology Knowledge

Vicki Stone, Mark R. Miller, Martin J. D. Clift, Alison Elder, Nicholas L. Mills, Peter Møller, Roel P. F. Schins, Ulla Vogel, Wolfgang G. Kreyling, Keld Alstrup Jensen, Thomas A. J. Kuhlbusch, Per E. Schwarze, Peter Hoet, Antonio Pietroiusti, Andrea De Vizcaya-Ruiz, Armelle Baeza-Squiban, C. Lang Tran, Flemming R. Cassee

Section of Environmental Health

151 Citations (Scopus)

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Abstract

BACKGROUND: A rich body of literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), and there is strong support for an important role of ultrafine (nanosized) particles. At present, relatively few human health or epidemiology data exist for engineered nanomaterials (NMs) despite clear parallels in their physicochemical properties and biological actions in in vitro models. OBJECTIVES: NMs are available with a range of physicochemical characteristics, which allows a more systematic toxicological analysis. Therefore, the study of ultrafine particles (UFP, <100 nm in diameter) provides an opportunity to identify plausible health effects for NMs, and the study of NMs provides an opportunity to facilitate the understanding of the mechanism of toxicity of UFP. METHODS: A workshop of experts systematically analyzed the available information and identified 19 key lessons that can facilitate knowledge exchange between these discipline areas. DISCUSSION: Key lessons range from the availability of specific techniques and standard protocols for physicochemical characterization and toxicology assessment to understanding and defining dose and the molecular mechanisms of toxicity. This review identifies a number of key areas in which additional research prioritization would facilitate both research fields simultaneously. CONCLUSION: There is now an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk research and vice versa.

Original language	English
Article number	EHP424
Journal	Environmental Health Perspectives
Volume	125
Issue number	10
Pages (from-to)	1-17
Number of pages	17
ISSN	0091-6765
DOIs	https://doi.org/10.1289/EHP424
Publication status	Published - 10 Oct 2017

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Stone, V., Miller, M. R., Clift, M. J. D., Elder, A., Mills, N. L., Møller, P., Schins, R. P. F., Vogel, U., Kreyling, W. G., Jensen, K. A., Kuhlbusch, T. A. J., Schwarze, P. E., Hoet, P., Pietroiusti, A., De Vizcaya-Ruiz, A., Baeza-Squiban, A., Tran, C. L., & Cassee, F. R. (2017). Nanomaterials vs Ambient Ultrafine Particles: an Opportunity to Exchange Toxicology Knowledge. Environmental Health Perspectives, 125(10), 1-17. [EHP424]. https://doi.org/10.1289/EHP424

Stone, V, Miller, MR, Clift, MJD, Elder, A, Mills, NL, Møller, P, Schins, RPF, Vogel, U, Kreyling, WG, Jensen, KA, Kuhlbusch, TAJ, Schwarze, PE, Hoet, P, Pietroiusti, A, De Vizcaya-Ruiz, A, Baeza-Squiban, A, Tran, CL & Cassee, FR 2017, 'Nanomaterials vs Ambient Ultrafine Particles: an Opportunity to Exchange Toxicology Knowledge', Environmental Health Perspectives, vol. 125, no. 10, EHP424, pp. 1-17. https://doi.org/10.1289/EHP424

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title = "Nanomaterials vs Ambient Ultrafine Particles: an Opportunity to Exchange Toxicology Knowledge",

abstract = "BACKGROUND: A rich body of literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), and there is strong support for an important role of ultrafine (nanosized) particles. At present, relatively few human health or epidemiology data exist for engineered nanomaterials (NMs) despite clear parallels in their physicochemical properties and biological actions in in vitro models. OBJECTIVES: NMs are available with a range of physicochemical characteristics, which allows a more systematic toxicological analysis. Therefore, the study of ultrafine particles (UFP, <100 nm in diameter) provides an opportunity to identify plausible health effects for NMs, and the study of NMs provides an opportunity to facilitate the understanding of the mechanism of toxicity of UFP. METHODS: A workshop of experts systematically analyzed the available information and identified 19 key lessons that can facilitate knowledge exchange between these discipline areas. DISCUSSION: Key lessons range from the availability of specific techniques and standard protocols for physicochemical characterization and toxicology assessment to understanding and defining dose and the molecular mechanisms of toxicity. This review identifies a number of key areas in which additional research prioritization would facilitate both research fields simultaneously. CONCLUSION: There is now an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk research and vice versa.",

author = "Vicki Stone and Miller, {Mark R.} and Clift, {Martin J. D.} and Alison Elder and Mills, {Nicholas L.} and Peter M{\o}ller and Schins, {Roel P. F.} and Ulla Vogel and Kreyling, {Wolfgang G.} and Jensen, {Keld Alstrup} and Kuhlbusch, {Thomas A. J.} and Schwarze, {Per E.} and Peter Hoet and Antonio Pietroiusti and {De Vizcaya-Ruiz}, Andrea and Armelle Baeza-Squiban and Tran, {C. Lang} and Cassee, {Flemming R.}",

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doi = "10.1289/EHP424",

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T2 - an Opportunity to Exchange Toxicology Knowledge

AU - Stone, Vicki

AU - Miller, Mark R.

AU - Clift, Martin J. D.

AU - Elder, Alison

AU - Mills, Nicholas L.

AU - Møller, Peter

AU - Schins, Roel P. F.

AU - Vogel, Ulla

AU - Kreyling, Wolfgang G.

AU - Jensen, Keld Alstrup

AU - Kuhlbusch, Thomas A. J.

AU - Schwarze, Per E.

AU - Hoet, Peter

AU - Pietroiusti, Antonio

AU - De Vizcaya-Ruiz, Andrea

AU - Baeza-Squiban, Armelle

AU - Tran, C. Lang

AU - Cassee, Flemming R.

PY - 2017/10/10

Y1 - 2017/10/10

N2 - BACKGROUND: A rich body of literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), and there is strong support for an important role of ultrafine (nanosized) particles. At present, relatively few human health or epidemiology data exist for engineered nanomaterials (NMs) despite clear parallels in their physicochemical properties and biological actions in in vitro models. OBJECTIVES: NMs are available with a range of physicochemical characteristics, which allows a more systematic toxicological analysis. Therefore, the study of ultrafine particles (UFP, <100 nm in diameter) provides an opportunity to identify plausible health effects for NMs, and the study of NMs provides an opportunity to facilitate the understanding of the mechanism of toxicity of UFP. METHODS: A workshop of experts systematically analyzed the available information and identified 19 key lessons that can facilitate knowledge exchange between these discipline areas. DISCUSSION: Key lessons range from the availability of specific techniques and standard protocols for physicochemical characterization and toxicology assessment to understanding and defining dose and the molecular mechanisms of toxicity. This review identifies a number of key areas in which additional research prioritization would facilitate both research fields simultaneously. CONCLUSION: There is now an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk research and vice versa.

AB - BACKGROUND: A rich body of literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), and there is strong support for an important role of ultrafine (nanosized) particles. At present, relatively few human health or epidemiology data exist for engineered nanomaterials (NMs) despite clear parallels in their physicochemical properties and biological actions in in vitro models. OBJECTIVES: NMs are available with a range of physicochemical characteristics, which allows a more systematic toxicological analysis. Therefore, the study of ultrafine particles (UFP, <100 nm in diameter) provides an opportunity to identify plausible health effects for NMs, and the study of NMs provides an opportunity to facilitate the understanding of the mechanism of toxicity of UFP. METHODS: A workshop of experts systematically analyzed the available information and identified 19 key lessons that can facilitate knowledge exchange between these discipline areas. DISCUSSION: Key lessons range from the availability of specific techniques and standard protocols for physicochemical characterization and toxicology assessment to understanding and defining dose and the molecular mechanisms of toxicity. This review identifies a number of key areas in which additional research prioritization would facilitate both research fields simultaneously. CONCLUSION: There is now an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk research and vice versa.

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DO - 10.1289/EHP424

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SN - 0091-6765

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JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

IS - 10

M1 - EHP424

ER -

Nanomaterials vs Ambient Ultrafine Particles: an Opportunity to Exchange Toxicology Knowledge

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