Abstract
There is strong evidence for enhanced numbers of satellite cells with heavy resistance training. The satellite cell response to very light muscle loading is, however, unknown. We, therefore, designed a 12-week training protocol where volunteers trained one leg with a high load (H) and the other leg with a light load (L). Twelve young healthy men [mean age 25 ± 3 standard deviation (SD) years] volunteered for the study. Muscle biopsies were collected from the m. vastus lateralis of both legs before and after the training period and satellite cells were visualized by CD56 immunohistochemistry. A significant main effect of time was observed (P<0.001) for the number of CD56+ cells per fiber (L: from 0.11 ± 0.02 to 0.13 ± 0.03; H: from 0.12 ± 0.03 to 0.15 ± 0.05, mean ± SD). The finding that 12 weeks of training skeletal muscle even with very light loads can induce an increase in the number of satellite cells reveals a new aspect of myogenic precursor cell activation and suggests that satellite cells may play a role in skeletal muscle adaptation over a broad physiological range.
| Original language | English |
|---|---|
| Journal | Scandinavian Journal of Medicine & Science in Sports |
| Volume | 21 |
| Issue number | 6 |
| Pages (from-to) | 773-82 |
| Number of pages | 10 |
| ISSN | 0905-7188 |
| DOIs | |
| Publication status | Published - Dec 2011 |
Keywords
- Adult
- Antigens, CD56
- Biopsy
- Denmark
- Humans
- Male
- Muscle Development
- Physical Exertion
- Quadriceps Muscle
- Resistance Training
- Satellite Cells, Skeletal Muscle
- Young Adult