Myogenic response of human skeletal muscle to 12 weeks of resistance training at light loading intensity

TY - JOUR

T1 - Myogenic response of human skeletal muscle to 12 weeks of resistance training at light loading intensity

AU - Mackey, Abigail

AU - Holm, L

AU - Reitelseder, S

AU - Pedersen, T G

AU - Doessing, S

AU - Kadi, F

AU - Kjaer, M

N1 - © 2010 John Wiley & Sons A/S.

PY - 2011/12

Y1 - 2011/12

N2 - There is strong evidence for enhanced numbers of satellite cells with heavy resistance training. The satellite cell response to very light muscle loading is, however, unknown. We, therefore, designed a 12-week training protocol where volunteers trained one leg with a high load (H) and the other leg with a light load (L). Twelve young healthy men [mean age 25 ± 3 standard deviation (SD) years] volunteered for the study. Muscle biopsies were collected from the m. vastus lateralis of both legs before and after the training period and satellite cells were visualized by CD56 immunohistochemistry. A significant main effect of time was observed (P<0.001) for the number of CD56+ cells per fiber (L: from 0.11 ± 0.02 to 0.13 ± 0.03; H: from 0.12 ± 0.03 to 0.15 ± 0.05, mean ± SD). The finding that 12 weeks of training skeletal muscle even with very light loads can induce an increase in the number of satellite cells reveals a new aspect of myogenic precursor cell activation and suggests that satellite cells may play a role in skeletal muscle adaptation over a broad physiological range.

AB - There is strong evidence for enhanced numbers of satellite cells with heavy resistance training. The satellite cell response to very light muscle loading is, however, unknown. We, therefore, designed a 12-week training protocol where volunteers trained one leg with a high load (H) and the other leg with a light load (L). Twelve young healthy men [mean age 25 ± 3 standard deviation (SD) years] volunteered for the study. Muscle biopsies were collected from the m. vastus lateralis of both legs before and after the training period and satellite cells were visualized by CD56 immunohistochemistry. A significant main effect of time was observed (P<0.001) for the number of CD56+ cells per fiber (L: from 0.11 ± 0.02 to 0.13 ± 0.03; H: from 0.12 ± 0.03 to 0.15 ± 0.05, mean ± SD). The finding that 12 weeks of training skeletal muscle even with very light loads can induce an increase in the number of satellite cells reveals a new aspect of myogenic precursor cell activation and suggests that satellite cells may play a role in skeletal muscle adaptation over a broad physiological range.

KW - Adult

KW - Antigens, CD56

KW - Biopsy

KW - Denmark

KW - Humans

KW - Male

KW - Muscle Development

KW - Physical Exertion

KW - Quadriceps Muscle

KW - Resistance Training

KW - Satellite Cells, Skeletal Muscle

KW - Young Adult

U2 - 10.1111/j.1600-0838.2010.01178.x

DO - 10.1111/j.1600-0838.2010.01178.x

M3 - Journal article

C2 - 21143306

SN - 0905-7188

VL - 21

SP - 773

EP - 782

JO - Scandinavian Journal of Medicine & Science in Sports

JF - Scandinavian Journal of Medicine & Science in Sports

IS - 6

ER -