Muscle growth is reduced in 15-month-old children with cerebral palsy

Anna Herskind; Anina Ritterband-Rosenbaum; Maria Willerslev-Olsen; Jakob Lorentzen; Lars Hanson; Glen Lichtwark; Jens Bo Nielsen

doi:10.1111/dmcn.12950

Muscle growth is reduced in 15-month-old children with cerebral palsy

Anna Herskind, Anina Ritterband-Rosenbaum, Maria Willerslev-Olsen, Jakob Lorentzen, Lars Hanson, Glen Lichtwark, Jens Bo Nielsen

Department of Neuroscience

54 Citations (Scopus)

Abstract

Aim: Lack of muscle growth relative to bone growth may be responsible for development of contractures in children with cerebral palsy (CP). Here, we used ultrasonography to compare growth of the medial gastrocnemius muscle in children with and without CP. Method: Twenty-six children with spastic CP (15 males, 11 females; mean age 35mo, range 8-65mo) and 101 typically developing children (47 males, 54 females; mean age 29mo, range 1-69mo) were included. Functional abilities of children with CP equalled levels I to III in the Gross Motor Function Classification System. Medial gastrocnemius muscle volume was constructed from serial, transverse, two-dimensional ultrasonography images. Results: In typically developing children, medial gastrocnemius volume increased linearly with age. Among children with CP, medial gastrocnemius volume increased less with age and deviated significantly from typically developing children at 15 months of age (p<0.05). Bone length increased with age without significant difference (p=0.49). Interpretation: Muscle growth in children with CP initially follows that of typically developing children, but decreases at 15 months of age. This may be related to reduced physical activity and neural activation of the muscle. Interventions stimulating muscle growth in young children with CP may be important to prevent contractures.

Original language	English
Journal	Developmental Medicine and Child Neurology
Volume	58
Issue number	5
Pages (from-to)	485-491
Number of pages	7
ISSN	0012-1622
DOIs	https://doi.org/10.1111/dmcn.12950
Publication status	Published - 1 May 2016

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title = "Muscle growth is reduced in 15-month-old children with cerebral palsy",

abstract = "Aim: Lack of muscle growth relative to bone growth may be responsible for development of contractures in children with cerebral palsy (CP). Here, we used ultrasonography to compare growth of the medial gastrocnemius muscle in children with and without CP. Method: Twenty-six children with spastic CP (15 males, 11 females; mean age 35mo, range 8-65mo) and 101 typically developing children (47 males, 54 females; mean age 29mo, range 1-69mo) were included. Functional abilities of children with CP equalled levels I to III in the Gross Motor Function Classification System. Medial gastrocnemius muscle volume was constructed from serial, transverse, two-dimensional ultrasonography images. Results: In typically developing children, medial gastrocnemius volume increased linearly with age. Among children with CP, medial gastrocnemius volume increased less with age and deviated significantly from typically developing children at 15 months of age (p<0.05). Bone length increased with age without significant difference (p=0.49). Interpretation: Muscle growth in children with CP initially follows that of typically developing children, but decreases at 15 months of age. This may be related to reduced physical activity and neural activation of the muscle. Interventions stimulating muscle growth in young children with CP may be important to prevent contractures.",

author = "Anna Herskind and Anina Ritterband-Rosenbaum and Maria Willerslev-Olsen and Jakob Lorentzen and Lars Hanson and Glen Lichtwark and Nielsen, {Jens Bo}",

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T1 - Muscle growth is reduced in 15-month-old children with cerebral palsy

AU - Herskind, Anna

AU - Ritterband-Rosenbaum, Anina

AU - Willerslev-Olsen, Maria

AU - Lorentzen, Jakob

AU - Hanson, Lars

AU - Lichtwark, Glen

AU - Nielsen, Jens Bo

N1 - CURIS 2016 NEXS 112

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Aim: Lack of muscle growth relative to bone growth may be responsible for development of contractures in children with cerebral palsy (CP). Here, we used ultrasonography to compare growth of the medial gastrocnemius muscle in children with and without CP. Method: Twenty-six children with spastic CP (15 males, 11 females; mean age 35mo, range 8-65mo) and 101 typically developing children (47 males, 54 females; mean age 29mo, range 1-69mo) were included. Functional abilities of children with CP equalled levels I to III in the Gross Motor Function Classification System. Medial gastrocnemius muscle volume was constructed from serial, transverse, two-dimensional ultrasonography images. Results: In typically developing children, medial gastrocnemius volume increased linearly with age. Among children with CP, medial gastrocnemius volume increased less with age and deviated significantly from typically developing children at 15 months of age (p<0.05). Bone length increased with age without significant difference (p=0.49). Interpretation: Muscle growth in children with CP initially follows that of typically developing children, but decreases at 15 months of age. This may be related to reduced physical activity and neural activation of the muscle. Interventions stimulating muscle growth in young children with CP may be important to prevent contractures.

AB - Aim: Lack of muscle growth relative to bone growth may be responsible for development of contractures in children with cerebral palsy (CP). Here, we used ultrasonography to compare growth of the medial gastrocnemius muscle in children with and without CP. Method: Twenty-six children with spastic CP (15 males, 11 females; mean age 35mo, range 8-65mo) and 101 typically developing children (47 males, 54 females; mean age 29mo, range 1-69mo) were included. Functional abilities of children with CP equalled levels I to III in the Gross Motor Function Classification System. Medial gastrocnemius muscle volume was constructed from serial, transverse, two-dimensional ultrasonography images. Results: In typically developing children, medial gastrocnemius volume increased linearly with age. Among children with CP, medial gastrocnemius volume increased less with age and deviated significantly from typically developing children at 15 months of age (p<0.05). Bone length increased with age without significant difference (p=0.49). Interpretation: Muscle growth in children with CP initially follows that of typically developing children, but decreases at 15 months of age. This may be related to reduced physical activity and neural activation of the muscle. Interventions stimulating muscle growth in young children with CP may be important to prevent contractures.

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DO - 10.1111/dmcn.12950

M3 - Journal article

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SN - 0012-1622

VL - 58

SP - 485

EP - 491

JO - Developmental Medicine and Child Neurology

JF - Developmental Medicine and Child Neurology

IS - 5

ER -

Muscle growth is reduced in 15-month-old children with cerebral palsy

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