Muscle growth is reduced in 15-month-old children with cerebral palsy

Anna Herskind; Anina Ritterband-Rosenbaum; Maria Willerslev-Olsen; Jakob Lorentzen; Lars Hanson; Glen Lichtwark; Jens Bo Nielsen

doi:10.1111/dmcn.12950

Muscle growth is reduced in 15-month-old children with cerebral palsy

Anna Herskind, Anina Ritterband-Rosenbaum, Maria Willerslev-Olsen, Jakob Lorentzen, Lars Hanson, Glen Lichtwark, Jens Bo Nielsen

Institut for Neurovidenskab

54 Citationer (Scopus)

Abstract

Aim: Lack of muscle growth relative to bone growth may be responsible for development of contractures in children with cerebral palsy (CP). Here, we used ultrasonography to compare growth of the medial gastrocnemius muscle in children with and without CP. Method: Twenty-six children with spastic CP (15 males, 11 females; mean age 35mo, range 8-65mo) and 101 typically developing children (47 males, 54 females; mean age 29mo, range 1-69mo) were included. Functional abilities of children with CP equalled levels I to III in the Gross Motor Function Classification System. Medial gastrocnemius muscle volume was constructed from serial, transverse, two-dimensional ultrasonography images. Results: In typically developing children, medial gastrocnemius volume increased linearly with age. Among children with CP, medial gastrocnemius volume increased less with age and deviated significantly from typically developing children at 15 months of age (p<0.05). Bone length increased with age without significant difference (p=0.49). Interpretation: Muscle growth in children with CP initially follows that of typically developing children, but decreases at 15 months of age. This may be related to reduced physical activity and neural activation of the muscle. Interventions stimulating muscle growth in young children with CP may be important to prevent contractures.

Originalsprog	Engelsk
Tidsskrift	Developmental Medicine and Child Neurology
Vol/bind	58
Udgave nummer	5
Sider (fra-til)	485-491
Antal sider	7
ISSN	0012-1622
DOI	https://doi.org/10.1111/dmcn.12950
Status	Udgivet - 1 maj 2016

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10.1111/dmcn.12950

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dmcn.12950

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title = "Muscle growth is reduced in 15-month-old children with cerebral palsy",

abstract = "Aim: Lack of muscle growth relative to bone growth may be responsible for development of contractures in children with cerebral palsy (CP). Here, we used ultrasonography to compare growth of the medial gastrocnemius muscle in children with and without CP. Method: Twenty-six children with spastic CP (15 males, 11 females; mean age 35mo, range 8-65mo) and 101 typically developing children (47 males, 54 females; mean age 29mo, range 1-69mo) were included. Functional abilities of children with CP equalled levels I to III in the Gross Motor Function Classification System. Medial gastrocnemius muscle volume was constructed from serial, transverse, two-dimensional ultrasonography images. Results: In typically developing children, medial gastrocnemius volume increased linearly with age. Among children with CP, medial gastrocnemius volume increased less with age and deviated significantly from typically developing children at 15 months of age (p<0.05). Bone length increased with age without significant difference (p=0.49). Interpretation: Muscle growth in children with CP initially follows that of typically developing children, but decreases at 15 months of age. This may be related to reduced physical activity and neural activation of the muscle. Interventions stimulating muscle growth in young children with CP may be important to prevent contractures.",

author = "Anna Herskind and Anina Ritterband-Rosenbaum and Maria Willerslev-Olsen and Jakob Lorentzen and Lars Hanson and Glen Lichtwark and Nielsen, {Jens Bo}",

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AU - Herskind, Anna

AU - Ritterband-Rosenbaum, Anina

AU - Willerslev-Olsen, Maria

AU - Lorentzen, Jakob

AU - Hanson, Lars

AU - Lichtwark, Glen

AU - Nielsen, Jens Bo

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N2 - Aim: Lack of muscle growth relative to bone growth may be responsible for development of contractures in children with cerebral palsy (CP). Here, we used ultrasonography to compare growth of the medial gastrocnemius muscle in children with and without CP. Method: Twenty-six children with spastic CP (15 males, 11 females; mean age 35mo, range 8-65mo) and 101 typically developing children (47 males, 54 females; mean age 29mo, range 1-69mo) were included. Functional abilities of children with CP equalled levels I to III in the Gross Motor Function Classification System. Medial gastrocnemius muscle volume was constructed from serial, transverse, two-dimensional ultrasonography images. Results: In typically developing children, medial gastrocnemius volume increased linearly with age. Among children with CP, medial gastrocnemius volume increased less with age and deviated significantly from typically developing children at 15 months of age (p<0.05). Bone length increased with age without significant difference (p=0.49). Interpretation: Muscle growth in children with CP initially follows that of typically developing children, but decreases at 15 months of age. This may be related to reduced physical activity and neural activation of the muscle. Interventions stimulating muscle growth in young children with CP may be important to prevent contractures.

AB - Aim: Lack of muscle growth relative to bone growth may be responsible for development of contractures in children with cerebral palsy (CP). Here, we used ultrasonography to compare growth of the medial gastrocnemius muscle in children with and without CP. Method: Twenty-six children with spastic CP (15 males, 11 females; mean age 35mo, range 8-65mo) and 101 typically developing children (47 males, 54 females; mean age 29mo, range 1-69mo) were included. Functional abilities of children with CP equalled levels I to III in the Gross Motor Function Classification System. Medial gastrocnemius muscle volume was constructed from serial, transverse, two-dimensional ultrasonography images. Results: In typically developing children, medial gastrocnemius volume increased linearly with age. Among children with CP, medial gastrocnemius volume increased less with age and deviated significantly from typically developing children at 15 months of age (p<0.05). Bone length increased with age without significant difference (p=0.49). Interpretation: Muscle growth in children with CP initially follows that of typically developing children, but decreases at 15 months of age. This may be related to reduced physical activity and neural activation of the muscle. Interventions stimulating muscle growth in young children with CP may be important to prevent contractures.

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C2 - 26510820

SN - 0419-0238

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SP - 485

EP - 491

JO - Developmental medicine and child neurology. Supplement

JF - Developmental medicine and child neurology. Supplement

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ER -

Muscle growth is reduced in 15-month-old children with cerebral palsy

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