Multimodality functional imaging of spontaneous canine tumors using 64CU-ATSM and 18FDG PET/CT and dynamic contrast enhanced perfusion CT

Anders E Hansen; Annemarie T Kristensen; Ian Law; Fintan McEvoy; Andreas Kjær; Svend A Engelholm

doi:10.1016/j.radonc.2011.10.021

Multimodality functional imaging of spontaneous canine tumors using ⁶⁴CU-ATSM and ¹⁸FDG PET/CT and dynamic contrast enhanced perfusion CT

Anders E Hansen, Annemarie T Kristensen, Ian Law, Fintan McEvoy, Andreas Kjær, Svend A Engelholm

Endocrinology and Metabolism

30 Citations (Scopus)

Abstract

Purpose: To compare the distribution and uptake of the hypoxia tracer ⁶⁴Cu-diacetyl-bis(N ⁴-methylthiosemicarbazone) ( ⁶⁴Cu-ATSM) PET/CT, FDG PET/CT and dynamic contrast enhanced perfusion CT (DCE-pCT) in spontaneous canine tumors. In addition ⁶⁴Cu-ATSM distribution over time was evaluated. Methods and materials: Nine spontaneous cancer-bearing dogs were prospectively enrolled. FDG (1 h pi.) and ⁶⁴Cu-ATSM (3 and 24 h pi.) PET/CT were performed over three consecutive days. DCE-pCT was performed on day 2. Tumor uptake of FDG and ⁶⁴Cu-ATSM was assessed semi-quantitatively and the distribution of FDG, ⁶⁴Cu-ATSM and CT perfusion parameters correlated. Results: ⁶⁴Cu-ATSM distribution on scans performed 24 h apart displayed moderate to strong correlation; however, temporal changes were observed. The spatial distribution pattern of ⁶⁴Cu-ATSM between scans was moderately to strongly positively correlated to FDG, whereas the correlation of CT perfusion parameters to FDG and to ⁶⁴Cu-ATSM yielded more varying results. Conclusions: ⁶⁴Cu-ATSM uptake was positively correlated to FDG. ⁶⁴Cu-ATSM was found to be relatively stable between PET scans performed at different time points, important temporal changes were however observed in hypo-perfused regions. These findings potentially indicate that prolonged uptake periods for ⁶⁴Cu-ATSM imaging may be needed. Although a moderate to strong correlation between ⁶⁴Cu-ATSM and FDG PET/CT is observed, the two tracers provide different biological information with an overlapping spatial distribution.

Original language	English
Journal	Radiotherapy & Oncology
Volume	102
Issue number	3
Pages (from-to)	424-428
Number of pages	5
ISSN	0167-8140
DOIs	https://doi.org/10.1016/j.radonc.2011.10.021
Publication status	Published - Mar 2012

Keywords

Animals
Contrast Media
Copper Radioisotopes
Dog Diseases
Dogs
Fluorodeoxyglucose F18
Neoplasms
Organometallic Compounds
Perfusion Imaging
Positron-Emission Tomography and Computed Tomography
Radiographic Image Enhancement
Radiopharmaceuticals
Thiosemicarbazones

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.radonc.2011.10.021

Cite this

@article{6e17072be65f44d580da4e7da89242db,

title = "Multimodality functional imaging of spontaneous canine tumors using 64CU-ATSM and 18FDG PET/CT and dynamic contrast enhanced perfusion CT",

abstract = "Purpose: To compare the distribution and uptake of the hypoxia tracer 64Cu-diacetyl-bis(N 4-methylthiosemicarbazone) ( 64Cu-ATSM) PET/CT, FDG PET/CT and dynamic contrast enhanced perfusion CT (DCE-pCT) in spontaneous canine tumors. In addition 64Cu-ATSM distribution over time was evaluated. Methods and materials: Nine spontaneous cancer-bearing dogs were prospectively enrolled. FDG (1 h pi.) and 64Cu-ATSM (3 and 24 h pi.) PET/CT were performed over three consecutive days. DCE-pCT was performed on day 2. Tumor uptake of FDG and 64Cu-ATSM was assessed semi-quantitatively and the distribution of FDG, 64Cu-ATSM and CT perfusion parameters correlated. Results: 64Cu-ATSM distribution on scans performed 24 h apart displayed moderate to strong correlation; however, temporal changes were observed. The spatial distribution pattern of 64Cu-ATSM between scans was moderately to strongly positively correlated to FDG, whereas the correlation of CT perfusion parameters to FDG and to 64Cu-ATSM yielded more varying results. Conclusions: 64Cu-ATSM uptake was positively correlated to FDG. 64Cu-ATSM was found to be relatively stable between PET scans performed at different time points, important temporal changes were however observed in hypo-perfused regions. These findings potentially indicate that prolonged uptake periods for 64Cu-ATSM imaging may be needed. Although a moderate to strong correlation between 64Cu-ATSM and FDG PET/CT is observed, the two tracers provide different biological information with an overlapping spatial distribution.",

keywords = "Animals, Contrast Media, Copper Radioisotopes, Dog Diseases, Dogs, Fluorodeoxyglucose F18, Neoplasms, Organometallic Compounds, Perfusion Imaging, Positron-Emission Tomography and Computed Tomography, Radiographic Image Enhancement, Radiopharmaceuticals, Thiosemicarbazones",

author = "Hansen, {Anders E} and Kristensen, {Annemarie T} and Ian Law and Fintan McEvoy and Andreas Kj{\ae}r and Engelholm, {Svend A}",

year = "2012",

month = mar,

doi = "10.1016/j.radonc.2011.10.021",

language = "English",

volume = "102",

pages = "424--428",

journal = "Radiotherapy & Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - Multimodality functional imaging of spontaneous canine tumors using 64CU-ATSM and 18FDG PET/CT and dynamic contrast enhanced perfusion CT

AU - Hansen, Anders E

AU - Kristensen, Annemarie T

AU - Law, Ian

AU - McEvoy, Fintan

AU - Kjær, Andreas

AU - Engelholm, Svend A

PY - 2012/3

Y1 - 2012/3

N2 - Purpose: To compare the distribution and uptake of the hypoxia tracer 64Cu-diacetyl-bis(N 4-methylthiosemicarbazone) ( 64Cu-ATSM) PET/CT, FDG PET/CT and dynamic contrast enhanced perfusion CT (DCE-pCT) in spontaneous canine tumors. In addition 64Cu-ATSM distribution over time was evaluated. Methods and materials: Nine spontaneous cancer-bearing dogs were prospectively enrolled. FDG (1 h pi.) and 64Cu-ATSM (3 and 24 h pi.) PET/CT were performed over three consecutive days. DCE-pCT was performed on day 2. Tumor uptake of FDG and 64Cu-ATSM was assessed semi-quantitatively and the distribution of FDG, 64Cu-ATSM and CT perfusion parameters correlated. Results: 64Cu-ATSM distribution on scans performed 24 h apart displayed moderate to strong correlation; however, temporal changes were observed. The spatial distribution pattern of 64Cu-ATSM between scans was moderately to strongly positively correlated to FDG, whereas the correlation of CT perfusion parameters to FDG and to 64Cu-ATSM yielded more varying results. Conclusions: 64Cu-ATSM uptake was positively correlated to FDG. 64Cu-ATSM was found to be relatively stable between PET scans performed at different time points, important temporal changes were however observed in hypo-perfused regions. These findings potentially indicate that prolonged uptake periods for 64Cu-ATSM imaging may be needed. Although a moderate to strong correlation between 64Cu-ATSM and FDG PET/CT is observed, the two tracers provide different biological information with an overlapping spatial distribution.

AB - Purpose: To compare the distribution and uptake of the hypoxia tracer 64Cu-diacetyl-bis(N 4-methylthiosemicarbazone) ( 64Cu-ATSM) PET/CT, FDG PET/CT and dynamic contrast enhanced perfusion CT (DCE-pCT) in spontaneous canine tumors. In addition 64Cu-ATSM distribution over time was evaluated. Methods and materials: Nine spontaneous cancer-bearing dogs were prospectively enrolled. FDG (1 h pi.) and 64Cu-ATSM (3 and 24 h pi.) PET/CT were performed over three consecutive days. DCE-pCT was performed on day 2. Tumor uptake of FDG and 64Cu-ATSM was assessed semi-quantitatively and the distribution of FDG, 64Cu-ATSM and CT perfusion parameters correlated. Results: 64Cu-ATSM distribution on scans performed 24 h apart displayed moderate to strong correlation; however, temporal changes were observed. The spatial distribution pattern of 64Cu-ATSM between scans was moderately to strongly positively correlated to FDG, whereas the correlation of CT perfusion parameters to FDG and to 64Cu-ATSM yielded more varying results. Conclusions: 64Cu-ATSM uptake was positively correlated to FDG. 64Cu-ATSM was found to be relatively stable between PET scans performed at different time points, important temporal changes were however observed in hypo-perfused regions. These findings potentially indicate that prolonged uptake periods for 64Cu-ATSM imaging may be needed. Although a moderate to strong correlation between 64Cu-ATSM and FDG PET/CT is observed, the two tracers provide different biological information with an overlapping spatial distribution.

KW - Animals

KW - Contrast Media

KW - Copper Radioisotopes

KW - Dog Diseases

KW - Dogs

KW - Fluorodeoxyglucose F18

KW - Neoplasms

KW - Organometallic Compounds

KW - Perfusion Imaging

KW - Positron-Emission Tomography and Computed Tomography

KW - Radiographic Image Enhancement

KW - Radiopharmaceuticals

KW - Thiosemicarbazones

U2 - 10.1016/j.radonc.2011.10.021

DO - 10.1016/j.radonc.2011.10.021

M3 - Journal article

C2 - 22119225

SN - 0167-8140

VL - 102

SP - 424

EP - 428

JO - Radiotherapy & Oncology

JF - Radiotherapy & Oncology

IS - 3

ER -