Abstract
Purpose: To compare the distribution and uptake of the hypoxia tracer 64Cu-diacetyl-bis(N 4-methylthiosemicarbazone) ( 64Cu-ATSM) PET/CT, FDG PET/CT and dynamic contrast enhanced perfusion CT (DCE-pCT) in spontaneous canine tumors. In addition 64Cu-ATSM distribution over time was evaluated. Methods and materials: Nine spontaneous cancer-bearing dogs were prospectively enrolled. FDG (1 h pi.) and 64Cu-ATSM (3 and 24 h pi.) PET/CT were performed over three consecutive days. DCE-pCT was performed on day 2. Tumor uptake of FDG and 64Cu-ATSM was assessed semi-quantitatively and the distribution of FDG, 64Cu-ATSM and CT perfusion parameters correlated. Results: 64Cu-ATSM distribution on scans performed 24 h apart displayed moderate to strong correlation; however, temporal changes were observed. The spatial distribution pattern of 64Cu-ATSM between scans was moderately to strongly positively correlated to FDG, whereas the correlation of CT perfusion parameters to FDG and to 64Cu-ATSM yielded more varying results. Conclusions: 64Cu-ATSM uptake was positively correlated to FDG. 64Cu-ATSM was found to be relatively stable between PET scans performed at different time points, important temporal changes were however observed in hypo-perfused regions. These findings potentially indicate that prolonged uptake periods for 64Cu-ATSM imaging may be needed. Although a moderate to strong correlation between 64Cu-ATSM and FDG PET/CT is observed, the two tracers provide different biological information with an overlapping spatial distribution.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Radiotherapy & Oncology |
| Vol/bind | 102 |
| Udgave nummer | 3 |
| Sider (fra-til) | 424-428 |
| Antal sider | 5 |
| ISSN | 0167-8140 |
| DOI | |
| Status | Udgivet - mar. 2012 |
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