MT1-mmp: a collagenase essential for tumor cell invasive growth

Kenn Holmbeck; Paolo Bianco; Henning Birkedal-Hansen

MT1-mmp: a collagenase essential for tumor cell invasive growth

Kenn Holmbeck, Paolo Bianco, Henning Birkedal-Hansen

19 Citations (Scopus)

Abstract

The manuscript discussed in this preview describes that reconstituted three-dimensional extracellular matrices such as fibrillar collagen and fibrin exert stringent territorial growth control on cells. The authors show that tumor cells are able to escape the matrix-enforced growth control effect (entrapment) by pericellular proteolysis mediated by MT1-MMP, a membrane bound matrix metalloproteinase capable of directly cleaving both type I collagen and fibrin but not by other, soluble matrix metalloprotinases. These data convincingly demonstrate one way that tumor cells orchestrate proteolysis to invade surrounding tissues.

Original language	English
Journal	Cancer Cell
Volume	4
Issue number	2
Pages (from-to)	83-4
Number of pages	2
ISSN	1535-6108
Publication status	Published - Aug 2003

Keywords

Animals
Cell Division
Collagen Type I/metabolism
Fibrin/metabolism
Matrix Metalloproteinases, Membrane-Associated
Metalloendopeptidases/metabolism
Neoplasm Invasiveness
Neoplasms/enzymology

Cite this

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title = "MT1-mmp: a collagenase essential for tumor cell invasive growth",

abstract = "The manuscript discussed in this preview describes that reconstituted three-dimensional extracellular matrices such as fibrillar collagen and fibrin exert stringent territorial growth control on cells. The authors show that tumor cells are able to escape the matrix-enforced growth control effect (entrapment) by pericellular proteolysis mediated by MT1-MMP, a membrane bound matrix metalloproteinase capable of directly cleaving both type I collagen and fibrin but not by other, soluble matrix metalloprotinases. These data convincingly demonstrate one way that tumor cells orchestrate proteolysis to invade surrounding tissues.",

keywords = "Animals, Cell Division, Collagen Type I/metabolism, Fibrin/metabolism, Matrix Metalloproteinases, Membrane-Associated, Metalloendopeptidases/metabolism, Neoplasm Invasiveness, Neoplasms/enzymology",

author = "Kenn Holmbeck and Paolo Bianco and Henning Birkedal-Hansen",

year = "2003",

month = aug,

language = "English",

volume = "4",

pages = "83--4",

journal = "Cancer Cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "2",

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TY - JOUR

T1 - MT1-mmp

T2 - a collagenase essential for tumor cell invasive growth

AU - Holmbeck, Kenn

AU - Bianco, Paolo

AU - Birkedal-Hansen, Henning

PY - 2003/8

Y1 - 2003/8

N2 - The manuscript discussed in this preview describes that reconstituted three-dimensional extracellular matrices such as fibrillar collagen and fibrin exert stringent territorial growth control on cells. The authors show that tumor cells are able to escape the matrix-enforced growth control effect (entrapment) by pericellular proteolysis mediated by MT1-MMP, a membrane bound matrix metalloproteinase capable of directly cleaving both type I collagen and fibrin but not by other, soluble matrix metalloprotinases. These data convincingly demonstrate one way that tumor cells orchestrate proteolysis to invade surrounding tissues.

AB - The manuscript discussed in this preview describes that reconstituted three-dimensional extracellular matrices such as fibrillar collagen and fibrin exert stringent territorial growth control on cells. The authors show that tumor cells are able to escape the matrix-enforced growth control effect (entrapment) by pericellular proteolysis mediated by MT1-MMP, a membrane bound matrix metalloproteinase capable of directly cleaving both type I collagen and fibrin but not by other, soluble matrix metalloprotinases. These data convincingly demonstrate one way that tumor cells orchestrate proteolysis to invade surrounding tissues.

KW - Animals

KW - Cell Division

KW - Collagen Type I/metabolism

KW - Fibrin/metabolism

KW - Matrix Metalloproteinases, Membrane-Associated

KW - Metalloendopeptidases/metabolism

KW - Neoplasm Invasiveness

KW - Neoplasms/enzymology

M3 - Journal article

C2 - 12957281

SN - 1535-6108

VL - 4

SP - 83

EP - 84

JO - Cancer Cell

JF - Cancer Cell

IS - 2

ER -

MT1-mmp: a collagenase essential for tumor cell invasive growth

Abstract

Keywords

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