MT1-mmp: a collagenase essential for tumor cell invasive growth

TY - JOUR

T1 - MT1-mmp

T2 - a collagenase essential for tumor cell invasive growth

AU - Holmbeck, Kenn

AU - Bianco, Paolo

AU - Birkedal-Hansen, Henning

PY - 2003/8

Y1 - 2003/8

N2 - The manuscript discussed in this preview describes that reconstituted three-dimensional extracellular matrices such as fibrillar collagen and fibrin exert stringent territorial growth control on cells. The authors show that tumor cells are able to escape the matrix-enforced growth control effect (entrapment) by pericellular proteolysis mediated by MT1-MMP, a membrane bound matrix metalloproteinase capable of directly cleaving both type I collagen and fibrin but not by other, soluble matrix metalloprotinases. These data convincingly demonstrate one way that tumor cells orchestrate proteolysis to invade surrounding tissues.

AB - The manuscript discussed in this preview describes that reconstituted three-dimensional extracellular matrices such as fibrillar collagen and fibrin exert stringent territorial growth control on cells. The authors show that tumor cells are able to escape the matrix-enforced growth control effect (entrapment) by pericellular proteolysis mediated by MT1-MMP, a membrane bound matrix metalloproteinase capable of directly cleaving both type I collagen and fibrin but not by other, soluble matrix metalloprotinases. These data convincingly demonstrate one way that tumor cells orchestrate proteolysis to invade surrounding tissues.

KW - Animals

KW - Cell Division

KW - Collagen Type I/metabolism

KW - Fibrin/metabolism

KW - Matrix Metalloproteinases, Membrane-Associated

KW - Metalloendopeptidases/metabolism

KW - Neoplasm Invasiveness

KW - Neoplasms/enzymology

M3 - Journal article

C2 - 12957281

SN - 1535-6108

VL - 4

SP - 83

EP - 84

JO - Cancer Cell

JF - Cancer Cell

IS - 2

ER -