Monitoring performance of progression assessment criteria for cancer antigen 125 among patients with ovarian cancer compared by computer simulation

TY - JOUR

T1 - Monitoring performance of progression assessment criteria for cancer antigen 125 among patients with ovarian cancer compared by computer simulation

AU - Abu Hassan, Suher Othman

AU - Petersen, Per Hyltoft

AU - Lund, Flemming

AU - Nielsen, Dorte L

AU - Tuxen, Malgorzata K

AU - Sölétormos, György

PY - 2015/9/1

Y1 - 2015/9/1

N2 - BACKGROUND: Cancer antigen 125 (CA125) is used to monitor tumor burden among patients with advanced serous epithelial ovarian cancer. The purpose is to compare the monitoring performance of seven previously proposed criteria.MATERIALS & METHODS: The CA125 assessment criteria were applied to simulated datasets. We investigated the ability to provide information on CA125 increments as well as their robustness against false positive signals.RESULTS: For baseline concentrations above cut-off, the best performing criterion was based on a confirmed increment ≥2.5-times the nadir concentration. For baseline concentrations below cut-off, the best performing criterion was based on a confirmed increment from ≤ cut-off to >two-times cut-off.DISCUSSION: Computer simulation models may be useful for a preclinical validation of criteria to be investigated in clinical trials.

AB - BACKGROUND: Cancer antigen 125 (CA125) is used to monitor tumor burden among patients with advanced serous epithelial ovarian cancer. The purpose is to compare the monitoring performance of seven previously proposed criteria.MATERIALS & METHODS: The CA125 assessment criteria were applied to simulated datasets. We investigated the ability to provide information on CA125 increments as well as their robustness against false positive signals.RESULTS: For baseline concentrations above cut-off, the best performing criterion was based on a confirmed increment ≥2.5-times the nadir concentration. For baseline concentrations below cut-off, the best performing criterion was based on a confirmed increment from ≤ cut-off to >two-times cut-off.DISCUSSION: Computer simulation models may be useful for a preclinical validation of criteria to be investigated in clinical trials.

U2 - 10.2217/bmm.15.47

DO - 10.2217/bmm.15.47

M3 - Journal article

C2 - 26145714

SN - 1752-0363

VL - 9

SP - 911

EP - 923

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

IS - 9

ER -