Monitoring performance of progression assessment criteria for cancer antigen 125 among patients with ovarian cancer compared by computer simulation

Suher Othman Abu Hassan; Per Hyltoft Petersen; Flemming Lund; Dorte L Nielsen; Malgorzata K Tuxen; György Sölétormos

doi:10.2217/bmm.15.47

Monitoring performance of progression assessment criteria for cancer antigen 125 among patients with ovarian cancer compared by computer simulation

Suher Othman Abu Hassan, Per Hyltoft Petersen, Flemming Lund, Dorte L Nielsen, Malgorzata K Tuxen, György Sölétormos

Institut for Klinisk Medicin

3 Citationer (Scopus)

Abstract

BACKGROUND: Cancer antigen 125 (CA125) is used to monitor tumor burden among patients with advanced serous epithelial ovarian cancer. The purpose is to compare the monitoring performance of seven previously proposed criteria.

MATERIALS & METHODS: The CA125 assessment criteria were applied to simulated datasets. We investigated the ability to provide information on CA125 increments as well as their robustness against false positive signals.

RESULTS: For baseline concentrations above cut-off, the best performing criterion was based on a confirmed increment ≥2.5-times the nadir concentration. For baseline concentrations below cut-off, the best performing criterion was based on a confirmed increment from ≤ cut-off to >two-times cut-off.

DISCUSSION: Computer simulation models may be useful for a preclinical validation of criteria to be investigated in clinical trials.

Originalsprog	Engelsk
Tidsskrift	Biomarkers in Medicine
Vol/bind	9
Udgave nummer	9
Sider (fra-til)	911-23
Antal sider	13
ISSN	1752-0363
DOI	https://doi.org/10.2217/bmm.15.47
Status	Udgivet - 1 sep. 2015

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10.2217/bmm.15.47

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Monitoring performance of progression assessment criteria for cancer antigen 125 among patients with ovarian cancer compared by computer simulation. / Abu Hassan, Suher Othman; Petersen, Per Hyltoft; Lund, Flemming et al.

I: Biomarkers in Medicine, Bind 9, Nr. 9, 01.09.2015, s. 911-23.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "Monitoring performance of progression assessment criteria for cancer antigen 125 among patients with ovarian cancer compared by computer simulation",

abstract = "BACKGROUND: Cancer antigen 125 (CA125) is used to monitor tumor burden among patients with advanced serous epithelial ovarian cancer. The purpose is to compare the monitoring performance of seven previously proposed criteria.MATERIALS & METHODS: The CA125 assessment criteria were applied to simulated datasets. We investigated the ability to provide information on CA125 increments as well as their robustness against false positive signals.RESULTS: For baseline concentrations above cut-off, the best performing criterion was based on a confirmed increment ≥2.5-times the nadir concentration. For baseline concentrations below cut-off, the best performing criterion was based on a confirmed increment from ≤ cut-off to >two-times cut-off.DISCUSSION: Computer simulation models may be useful for a preclinical validation of criteria to be investigated in clinical trials.",

author = "{Abu Hassan}, {Suher Othman} and Petersen, {Per Hyltoft} and Flemming Lund and Nielsen, {Dorte L} and Tuxen, {Malgorzata K} and Gy{\"o}rgy S{\"o}l{\'e}tormos",

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doi = "10.2217/bmm.15.47",

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T1 - Monitoring performance of progression assessment criteria for cancer antigen 125 among patients with ovarian cancer compared by computer simulation

AU - Abu Hassan, Suher Othman

AU - Petersen, Per Hyltoft

AU - Lund, Flemming

AU - Nielsen, Dorte L

AU - Tuxen, Malgorzata K

AU - Sölétormos, György

PY - 2015/9/1

Y1 - 2015/9/1

N2 - BACKGROUND: Cancer antigen 125 (CA125) is used to monitor tumor burden among patients with advanced serous epithelial ovarian cancer. The purpose is to compare the monitoring performance of seven previously proposed criteria.MATERIALS & METHODS: The CA125 assessment criteria were applied to simulated datasets. We investigated the ability to provide information on CA125 increments as well as their robustness against false positive signals.RESULTS: For baseline concentrations above cut-off, the best performing criterion was based on a confirmed increment ≥2.5-times the nadir concentration. For baseline concentrations below cut-off, the best performing criterion was based on a confirmed increment from ≤ cut-off to >two-times cut-off.DISCUSSION: Computer simulation models may be useful for a preclinical validation of criteria to be investigated in clinical trials.

AB - BACKGROUND: Cancer antigen 125 (CA125) is used to monitor tumor burden among patients with advanced serous epithelial ovarian cancer. The purpose is to compare the monitoring performance of seven previously proposed criteria.MATERIALS & METHODS: The CA125 assessment criteria were applied to simulated datasets. We investigated the ability to provide information on CA125 increments as well as their robustness against false positive signals.RESULTS: For baseline concentrations above cut-off, the best performing criterion was based on a confirmed increment ≥2.5-times the nadir concentration. For baseline concentrations below cut-off, the best performing criterion was based on a confirmed increment from ≤ cut-off to >two-times cut-off.DISCUSSION: Computer simulation models may be useful for a preclinical validation of criteria to be investigated in clinical trials.

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DO - 10.2217/bmm.15.47

M3 - Journal article

C2 - 26145714

SN - 1752-0363

VL - 9

SP - 911

EP - 923

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

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Monitoring performance of progression assessment criteria for cancer antigen 125 among patients with ovarian cancer compared by computer simulation

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