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Molecular pharmacology of the AMPA agonist, (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA] and the AMPA antagonist, (R)-APPA
B Ebert,
U Madsen
,
Trine Meldgaard Lund
, S M Lenz,
P Krogsgaard-Larsen
25
Citations (Scopus)
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Dive into the research topics of 'Molecular pharmacology of the AMPA agonist, (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA] and the AMPA antagonist, (R)-APPA'. Together they form a unique fingerprint.
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Keyphrases
AMPA Antagonist
100%
Molecular Pharmacology
100%
Propionic Acid
100%
AMPA Receptor (AMPAR)
100%
2-amino-3
100%
Phenyl
100%
Receptor Agonist
75%
Competitive Antagonist
50%
Cyano
50%
3-dione
50%
Receptor Conformation
50%
Methyl
50%
Low Affinity
25%
Enantiomeric
25%
Molar Ratio
25%
Classical Theory
25%
Nitro
25%
High-affinity Receptor
25%
Partial Agonism
25%
Receptor Antagonist
25%
N-methyl-D-aspartic Acid Receptor
25%
Glutamic Acid
25%
Depolarization
25%
Competitive Interactions
25%
Blocking Effect
25%
Quinoxaline-2,3-dione
25%
Pharmacology, Toxicology and Pharmaceutical Science
Molecular Pharmacology
100%
Propionic Acid
100%
Alpha Amino 3 Hydroxy 5 Methyl 4 Isoxazolepropionic Acid
100%
AMPA Receptor Agonist
30%
NBQX
20%
Competitive Antagonist
20%
Receptor Antagonist
10%
AMPA Receptor
10%
Receptor
10%
Aspartic Acid
10%
Glutamic Acid
10%
Thiocyanate
10%