Molecular motor transport through hollow nanowires

Mercy Lard; Lasse Ten Siethoff; Johanna Generosi; Alf Månsson; Heiner Linke

doi:10.1021/nl404714b

Molecular motor transport through hollow nanowires

Mercy Lard^*, Lasse Ten Siethoff, Johanna Generosi, Alf Månsson, Heiner Linke

^*Corresponding author for this work

Department of Chemistry

25 Citations (Scopus)

Abstract

Biomolecular motors offer self-propelled, directed transport in designed microscale networks and can potentially replace pump-driven nanofluidics. However, in existing systems, transportation is limited to the two-dimensional plane. Here we demonstrate fully one-dimensional (1D) myosin-driven motion of fluorescent probes (actin filaments) through 80 nm wide, Al₂O ₃ hollow nanowires of micrometer length. The motor-driven transport is orders of magnitude faster than would be possible by passive diffusion. The system represents a necessary element for advanced devices based on gliding assays, for example, in lab-on-a-chip systems with channel crossings and in pumpless nanosyringes. It may also serve as a scaffold for bottom-up assembly of muscle proteins into ordered contractile units, mimicking the muscle sarcomere.

Original language	English
Journal	Nano Letters
Volume	14
Issue number	6
Pages (from-to)	3041-3046
Number of pages	6
ISSN	1530-6984
DOIs	https://doi.org/10.1021/nl404714b
Publication status	Published - 2014

Keywords

1D gliding assay
actin
Hollow nanowires
molecular motors
motor proteins
myosin

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title = "Molecular motor transport through hollow nanowires",

abstract = "Biomolecular motors offer self-propelled, directed transport in designed microscale networks and can potentially replace pump-driven nanofluidics. However, in existing systems, transportation is limited to the two-dimensional plane. Here we demonstrate fully one-dimensional (1D) myosin-driven motion of fluorescent probes (actin filaments) through 80 nm wide, Al2O 3 hollow nanowires of micrometer length. The motor-driven transport is orders of magnitude faster than would be possible by passive diffusion. The system represents a necessary element for advanced devices based on gliding assays, for example, in lab-on-a-chip systems with channel crossings and in pumpless nanosyringes. It may also serve as a scaffold for bottom-up assembly of muscle proteins into ordered contractile units, mimicking the muscle sarcomere.",

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TY - JOUR

T1 - Molecular motor transport through hollow nanowires

AU - Lard, Mercy

AU - Ten Siethoff, Lasse

AU - Generosi, Johanna

AU - Månsson, Alf

AU - Linke, Heiner

PY - 2014

Y1 - 2014

N2 - Biomolecular motors offer self-propelled, directed transport in designed microscale networks and can potentially replace pump-driven nanofluidics. However, in existing systems, transportation is limited to the two-dimensional plane. Here we demonstrate fully one-dimensional (1D) myosin-driven motion of fluorescent probes (actin filaments) through 80 nm wide, Al2O 3 hollow nanowires of micrometer length. The motor-driven transport is orders of magnitude faster than would be possible by passive diffusion. The system represents a necessary element for advanced devices based on gliding assays, for example, in lab-on-a-chip systems with channel crossings and in pumpless nanosyringes. It may also serve as a scaffold for bottom-up assembly of muscle proteins into ordered contractile units, mimicking the muscle sarcomere.

AB - Biomolecular motors offer self-propelled, directed transport in designed microscale networks and can potentially replace pump-driven nanofluidics. However, in existing systems, transportation is limited to the two-dimensional plane. Here we demonstrate fully one-dimensional (1D) myosin-driven motion of fluorescent probes (actin filaments) through 80 nm wide, Al2O 3 hollow nanowires of micrometer length. The motor-driven transport is orders of magnitude faster than would be possible by passive diffusion. The system represents a necessary element for advanced devices based on gliding assays, for example, in lab-on-a-chip systems with channel crossings and in pumpless nanosyringes. It may also serve as a scaffold for bottom-up assembly of muscle proteins into ordered contractile units, mimicking the muscle sarcomere.

KW - 1D gliding assay

KW - actin

KW - Hollow nanowires

KW - molecular motors

KW - motor proteins

KW - myosin

U2 - 10.1021/nl404714b

DO - 10.1021/nl404714b

M3 - Journal article

C2 - 24874101

AN - SCOPUS:84902250949

SN - 1530-6984

VL - 14

SP - 3041

EP - 3046

JO - Nano Letters

JF - Nano Letters

IS - 6

ER -

Molecular motor transport through hollow nanowires

Abstract

Keywords

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