Molecular identification of the insect adipokinetic hormone receptors.

Frank Staubli; Thomas J D Jørgensen; Giuseppe Cazzamali; Michael Williamson; Camilla Lenz; Leif Søndergaard; Peter Roepstorff; Cornelis J P Grimmelikhuijzen

doi:10.1073/pnas.052556499

Molecular identification of the insect adipokinetic hormone receptors.

Frank Staubli, Thomas J D Jørgensen, Giuseppe Cazzamali, Michael Williamson, Camilla Lenz, Leif Søndergaard, Peter Roepstorff, Cornelis J P Grimmelikhuijzen

234 Citations (Scopus)

Abstract

The insect adipokinetic hormones (AKHs) are a large family of peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion, but that also contribute to hemolymph sugar homeostasis. Here, we have identified the first insect AKH receptors, namely those from the fruitfly Drosophila melanogaster and the silkworm Bombyx mori. These results represent a breakthrough for insect molecular endocrinology, because it will lead to the cloning of all AKH receptors from all model insects used in AKH research, and, therefore, to a better understanding of AKH heterogeneity and actions. Interestingly, the insect AKH receptors are structurally and evolutionarily related to the gonadotropin-releasing hormone receptors from vertebrates.

Original language	English
Journal	Proceedings of the National Academy of Science of the United States of America
Volume	99
Issue number	6
Pages (from-to)	3446-51
Number of pages	5
ISSN	0027-8424
DOIs	https://doi.org/10.1073/pnas.052556499
Publication status	Published - 2002

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@article{100767c0ec2811dcbee902004c4f4f50,

title = "Molecular identification of the insect adipokinetic hormone receptors.",

abstract = "The insect adipokinetic hormones (AKHs) are a large family of peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion, but that also contribute to hemolymph sugar homeostasis. Here, we have identified the first insect AKH receptors, namely those from the fruitfly Drosophila melanogaster and the silkworm Bombyx mori. These results represent a breakthrough for insect molecular endocrinology, because it will lead to the cloning of all AKH receptors from all model insects used in AKH research, and, therefore, to a better understanding of AKH heterogeneity and actions. Interestingly, the insect AKH receptors are structurally and evolutionarily related to the gonadotropin-releasing hormone receptors from vertebrates.",

author = "Frank Staubli and J{\o}rgensen, {Thomas J D} and Giuseppe Cazzamali and Michael Williamson and Camilla Lenz and Leif S{\o}ndergaard and Peter Roepstorff and Grimmelikhuijzen, {Cornelis J P}",

note = "Keywords: Amino Acid Sequence; Animals; Bombyx; CHO Cells; Chromatography, High Pressure Liquid; Circular Dichroism; Cloning, Molecular; Cricetinae; Drosophila Proteins; Drosophila melanogaster; Insect Hormones; Insect Proteins; Ligands; Luminescent Measurements; Molecular Sequence Data; Oligopeptides; Pyrrolidonecarboxylic Acid; Receptors, Cell Surface; Receptors, LHRH; Sequence Alignment; Spectrometry, Mass, Electrospray Ionization",

year = "2002",

doi = "10.1073/pnas.052556499",

language = "English",

volume = "99",

pages = "3446--51",

journal = "Proceedings of the National Academy of Science of the United States of America",

issn = "0027-8424",

publisher = "The National Academy of Sciences of the United States of America",

number = "6",

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T1 - Molecular identification of the insect adipokinetic hormone receptors.

AU - Staubli, Frank

AU - Jørgensen, Thomas J D

AU - Cazzamali, Giuseppe

AU - Williamson, Michael

AU - Lenz, Camilla

AU - Søndergaard, Leif

AU - Roepstorff, Peter

AU - Grimmelikhuijzen, Cornelis J P

N1 - Keywords: Amino Acid Sequence; Animals; Bombyx; CHO Cells; Chromatography, High Pressure Liquid; Circular Dichroism; Cloning, Molecular; Cricetinae; Drosophila Proteins; Drosophila melanogaster; Insect Hormones; Insect Proteins; Ligands; Luminescent Measurements; Molecular Sequence Data; Oligopeptides; Pyrrolidonecarboxylic Acid; Receptors, Cell Surface; Receptors, LHRH; Sequence Alignment; Spectrometry, Mass, Electrospray Ionization

PY - 2002

Y1 - 2002

N2 - The insect adipokinetic hormones (AKHs) are a large family of peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion, but that also contribute to hemolymph sugar homeostasis. Here, we have identified the first insect AKH receptors, namely those from the fruitfly Drosophila melanogaster and the silkworm Bombyx mori. These results represent a breakthrough for insect molecular endocrinology, because it will lead to the cloning of all AKH receptors from all model insects used in AKH research, and, therefore, to a better understanding of AKH heterogeneity and actions. Interestingly, the insect AKH receptors are structurally and evolutionarily related to the gonadotropin-releasing hormone receptors from vertebrates.

AB - The insect adipokinetic hormones (AKHs) are a large family of peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion, but that also contribute to hemolymph sugar homeostasis. Here, we have identified the first insect AKH receptors, namely those from the fruitfly Drosophila melanogaster and the silkworm Bombyx mori. These results represent a breakthrough for insect molecular endocrinology, because it will lead to the cloning of all AKH receptors from all model insects used in AKH research, and, therefore, to a better understanding of AKH heterogeneity and actions. Interestingly, the insect AKH receptors are structurally and evolutionarily related to the gonadotropin-releasing hormone receptors from vertebrates.

U2 - 10.1073/pnas.052556499

DO - 10.1073/pnas.052556499

M3 - Journal article

C2 - 11904407

SN - 0027-8424

VL - 99

SP - 3446

EP - 3451

JO - Proceedings of the National Academy of Science of the United States of America

JF - Proceedings of the National Academy of Science of the United States of America

IS - 6

ER -

Molecular identification of the insect adipokinetic hormone receptors.

Abstract

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