TY - JOUR
T1 - Molecular identification of the insect adipokinetic hormone receptors.
AU - Staubli, Frank
AU - Jørgensen, Thomas J D
AU - Cazzamali, Giuseppe
AU - Williamson, Michael
AU - Lenz, Camilla
AU - Søndergaard, Leif
AU - Roepstorff, Peter
AU - Grimmelikhuijzen, Cornelis J P
N1 - Keywords: Amino Acid Sequence; Animals; Bombyx; CHO Cells; Chromatography, High Pressure Liquid; Circular Dichroism; Cloning, Molecular; Cricetinae; Drosophila Proteins; Drosophila melanogaster; Insect Hormones; Insect Proteins; Ligands; Luminescent Measurements; Molecular Sequence Data; Oligopeptides; Pyrrolidonecarboxylic Acid; Receptors, Cell Surface; Receptors, LHRH; Sequence Alignment; Spectrometry, Mass, Electrospray Ionization
PY - 2002
Y1 - 2002
N2 - The insect adipokinetic hormones (AKHs) are a large family of peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion, but that also contribute to hemolymph sugar homeostasis. Here, we have identified the first insect AKH receptors, namely those from the fruitfly Drosophila melanogaster and the silkworm Bombyx mori. These results represent a breakthrough for insect molecular endocrinology, because it will lead to the cloning of all AKH receptors from all model insects used in AKH research, and, therefore, to a better understanding of AKH heterogeneity and actions. Interestingly, the insect AKH receptors are structurally and evolutionarily related to the gonadotropin-releasing hormone receptors from vertebrates.
AB - The insect adipokinetic hormones (AKHs) are a large family of peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion, but that also contribute to hemolymph sugar homeostasis. Here, we have identified the first insect AKH receptors, namely those from the fruitfly Drosophila melanogaster and the silkworm Bombyx mori. These results represent a breakthrough for insect molecular endocrinology, because it will lead to the cloning of all AKH receptors from all model insects used in AKH research, and, therefore, to a better understanding of AKH heterogeneity and actions. Interestingly, the insect AKH receptors are structurally and evolutionarily related to the gonadotropin-releasing hormone receptors from vertebrates.
U2 - 10.1073/pnas.052556499
DO - 10.1073/pnas.052556499
M3 - Journal article
C2 - 11904407
SN - 0027-8424
VL - 99
SP - 3446
EP - 3451
JO - Proceedings of the National Academy of Science of the United States of America
JF - Proceedings of the National Academy of Science of the United States of America
IS - 6
ER -