Molecular biomarkers have the potential to improve the diagnostic work-up of pancreatic cystic lesions

Julie Isabelle Plougmann; Pia Klausen; John Gásdal Karstensen; Peter Vilmann; Jane Preuss Hasselby; Carsten Palnæs Hansen; Evangelos Kalaitzakis

Molecular biomarkers have the potential to improve the diagnostic work-up of pancreatic cystic lesions

Julie Isabelle Plougmann, Pia Klausen, John Gásdal Karstensen, Peter Vilmann, Jane Preuss Hasselby, Carsten Palnæs Hansen, Evangelos Kalaitzakis

Department of Clinical Medicine

3 Citations (Scopus)

Abstract

Pancreatic cysts are increasingly diagnosed due to the widespread use of cross-sectional imaging, and some of these lesions harbor malignant potential. Mucinous cystic neoplasms and intraductal papillary mucinous neoplasms are the major premalignant cystic neoplasms of the pancreas. A variety of diagnostic tools are used to predict the malignant potential of these cysts, but specificity and sensitivity are limited. Thus, many patients undergo unnecessary operations for benign cysts. Balancing the risks of watchful waiting with those of operative management is key in managing these lesions. During the last decade, genetic changes of pancreatic cysts have been examined extensively to estimate their malignant potential. In this review, we provide an overview of the latest molecular and genetic aspects of pancreatic cysts and how they may contribute to the differential diagnosis in patients with pancreatic cystic neoplasms.

Original language	English
Book series	Scandinavian Journal of Gastroenterology
Volume	52
Issue number	9
Pages (from-to)	932-940
Number of pages	9
ISSN	0085-5928
Publication status	Published - 2 Sept 2017

Keywords

Journal Article

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http://www.tandfonline.com/doi/abs/10.1080/00365521.2017.1333628

Cite this

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title = "Molecular biomarkers have the potential to improve the diagnostic work-up of pancreatic cystic lesions",

abstract = "Pancreatic cysts are increasingly diagnosed due to the widespread use of cross-sectional imaging, and some of these lesions harbor malignant potential. Mucinous cystic neoplasms and intraductal papillary mucinous neoplasms are the major premalignant cystic neoplasms of the pancreas. A variety of diagnostic tools are used to predict the malignant potential of these cysts, but specificity and sensitivity are limited. Thus, many patients undergo unnecessary operations for benign cysts. Balancing the risks of watchful waiting with those of operative management is key in managing these lesions. During the last decade, genetic changes of pancreatic cysts have been examined extensively to estimate their malignant potential. In this review, we provide an overview of the latest molecular and genetic aspects of pancreatic cysts and how they may contribute to the differential diagnosis in patients with pancreatic cystic neoplasms.",

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AU - Plougmann, Julie Isabelle

AU - Klausen, Pia

AU - Karstensen, John Gásdal

AU - Vilmann, Peter

AU - Hasselby, Jane Preuss

AU - Hansen, Carsten Palnæs

AU - Kalaitzakis, Evangelos

PY - 2017/9/2

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N2 - Pancreatic cysts are increasingly diagnosed due to the widespread use of cross-sectional imaging, and some of these lesions harbor malignant potential. Mucinous cystic neoplasms and intraductal papillary mucinous neoplasms are the major premalignant cystic neoplasms of the pancreas. A variety of diagnostic tools are used to predict the malignant potential of these cysts, but specificity and sensitivity are limited. Thus, many patients undergo unnecessary operations for benign cysts. Balancing the risks of watchful waiting with those of operative management is key in managing these lesions. During the last decade, genetic changes of pancreatic cysts have been examined extensively to estimate their malignant potential. In this review, we provide an overview of the latest molecular and genetic aspects of pancreatic cysts and how they may contribute to the differential diagnosis in patients with pancreatic cystic neoplasms.

AB - Pancreatic cysts are increasingly diagnosed due to the widespread use of cross-sectional imaging, and some of these lesions harbor malignant potential. Mucinous cystic neoplasms and intraductal papillary mucinous neoplasms are the major premalignant cystic neoplasms of the pancreas. A variety of diagnostic tools are used to predict the malignant potential of these cysts, but specificity and sensitivity are limited. Thus, many patients undergo unnecessary operations for benign cysts. Balancing the risks of watchful waiting with those of operative management is key in managing these lesions. During the last decade, genetic changes of pancreatic cysts have been examined extensively to estimate their malignant potential. In this review, we provide an overview of the latest molecular and genetic aspects of pancreatic cysts and how they may contribute to the differential diagnosis in patients with pancreatic cystic neoplasms.

KW - Journal Article

M3 - Review

C2 - 28552018

SN - 0085-5928

VL - 52

SP - 932

EP - 940

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

IS - 9

ER -

Molecular biomarkers have the potential to improve the diagnostic work-up of pancreatic cystic lesions

Abstract

Keywords

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