Molecular biomarkers have the potential to improve the diagnostic work-up of pancreatic cystic lesions

Julie Isabelle Plougmann; Pia Klausen; John Gásdal Karstensen; Peter Vilmann; Jane Preuss Hasselby; Carsten Palnæs Hansen; Evangelos Kalaitzakis

Molecular biomarkers have the potential to improve the diagnostic work-up of pancreatic cystic lesions

Julie Isabelle Plougmann, Pia Klausen, John Gásdal Karstensen, Peter Vilmann, Jane Preuss Hasselby, Carsten Palnæs Hansen, Evangelos Kalaitzakis

Institut for Klinisk Medicin

3 Citationer (Scopus)

Abstract

Pancreatic cysts are increasingly diagnosed due to the widespread use of cross-sectional imaging, and some of these lesions harbor malignant potential. Mucinous cystic neoplasms and intraductal papillary mucinous neoplasms are the major premalignant cystic neoplasms of the pancreas. A variety of diagnostic tools are used to predict the malignant potential of these cysts, but specificity and sensitivity are limited. Thus, many patients undergo unnecessary operations for benign cysts. Balancing the risks of watchful waiting with those of operative management is key in managing these lesions. During the last decade, genetic changes of pancreatic cysts have been examined extensively to estimate their malignant potential. In this review, we provide an overview of the latest molecular and genetic aspects of pancreatic cysts and how they may contribute to the differential diagnosis in patients with pancreatic cystic neoplasms.

Originalsprog	Engelsk
Bogserie	Scandinavian Journal of Gastroenterology
Vol/bind	52
Udgave nummer	9
Sider (fra-til)	932-940
Antal sider	9
ISSN	0085-5928
Status	Udgivet - 2 sep. 2017

Adgang til dokumentet

http://www.tandfonline.com/doi/abs/10.1080/00365521.2017.1333628

Citationsformater

@article{8035f0c4f9a74325aeda8328112a91d8,

title = "Molecular biomarkers have the potential to improve the diagnostic work-up of pancreatic cystic lesions",

abstract = "Pancreatic cysts are increasingly diagnosed due to the widespread use of cross-sectional imaging, and some of these lesions harbor malignant potential. Mucinous cystic neoplasms and intraductal papillary mucinous neoplasms are the major premalignant cystic neoplasms of the pancreas. A variety of diagnostic tools are used to predict the malignant potential of these cysts, but specificity and sensitivity are limited. Thus, many patients undergo unnecessary operations for benign cysts. Balancing the risks of watchful waiting with those of operative management is key in managing these lesions. During the last decade, genetic changes of pancreatic cysts have been examined extensively to estimate their malignant potential. In this review, we provide an overview of the latest molecular and genetic aspects of pancreatic cysts and how they may contribute to the differential diagnosis in patients with pancreatic cystic neoplasms.",

keywords = "Journal Article",

author = "Plougmann, {Julie Isabelle} and Pia Klausen and Karstensen, {John G{\'a}sdal} and Peter Vilmann and Hasselby, {Jane Preuss} and Hansen, {Carsten Paln{\ae}s} and Evangelos Kalaitzakis",

year = "2017",

month = sep,

day = "2",

language = "English",

volume = "52",

pages = "932--940",

journal = "Scandinavian Journal of Gastroenterology",

issn = "0085-5928",

publisher = "Taylor & Francis",

number = "9",

}

TY - JOUR

T1 - Molecular biomarkers have the potential to improve the diagnostic work-up of pancreatic cystic lesions

AU - Plougmann, Julie Isabelle

AU - Klausen, Pia

AU - Karstensen, John Gásdal

AU - Vilmann, Peter

AU - Hasselby, Jane Preuss

AU - Hansen, Carsten Palnæs

AU - Kalaitzakis, Evangelos

PY - 2017/9/2

Y1 - 2017/9/2

N2 - Pancreatic cysts are increasingly diagnosed due to the widespread use of cross-sectional imaging, and some of these lesions harbor malignant potential. Mucinous cystic neoplasms and intraductal papillary mucinous neoplasms are the major premalignant cystic neoplasms of the pancreas. A variety of diagnostic tools are used to predict the malignant potential of these cysts, but specificity and sensitivity are limited. Thus, many patients undergo unnecessary operations for benign cysts. Balancing the risks of watchful waiting with those of operative management is key in managing these lesions. During the last decade, genetic changes of pancreatic cysts have been examined extensively to estimate their malignant potential. In this review, we provide an overview of the latest molecular and genetic aspects of pancreatic cysts and how they may contribute to the differential diagnosis in patients with pancreatic cystic neoplasms.

AB - Pancreatic cysts are increasingly diagnosed due to the widespread use of cross-sectional imaging, and some of these lesions harbor malignant potential. Mucinous cystic neoplasms and intraductal papillary mucinous neoplasms are the major premalignant cystic neoplasms of the pancreas. A variety of diagnostic tools are used to predict the malignant potential of these cysts, but specificity and sensitivity are limited. Thus, many patients undergo unnecessary operations for benign cysts. Balancing the risks of watchful waiting with those of operative management is key in managing these lesions. During the last decade, genetic changes of pancreatic cysts have been examined extensively to estimate their malignant potential. In this review, we provide an overview of the latest molecular and genetic aspects of pancreatic cysts and how they may contribute to the differential diagnosis in patients with pancreatic cystic neoplasms.

KW - Journal Article

M3 - Review

C2 - 28552018

SN - 0085-5928

VL - 52

SP - 932

EP - 940

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

IS - 9

ER -

Molecular biomarkers have the potential to improve the diagnostic work-up of pancreatic cystic lesions

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater